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In addition to a majority of insulin-producing β-cells, the mammalian pancreatic islets contain considerable numbers of α1- and α2-cells. While the α2-cells are the cellular source of glucagon, the secretory product stored in the granules of the α1-cells still remains to be identified.Several authors have reported that glucagon stimulates insulin release. This effect of glucagon was found to be de
A seemingly never-ending stream of observers claims that the populist emphasis on nationalism, identity, and popular sovereignty undermines international collaboration and contributes to the crisis of the Liberal International Order (LIO). Why, then, do populist governments continue to engage in regional and international institutions? This Element unpacks the counter-intuitive inclination towards
Debate and literature on the link between degrading environments and human mobility has been increasing exponentially. There is little concrete evidence, however, of efforts or policies that support the management of environmentally influenced mobility. Through discourse analysis using Q-methodology, this research aimed to scrutinize the standoff between opposing views under a fresh lens. One-hund
Celebrated by some as a ‘new’ mode of governance (Sabel and Zeitlin 2008) and experimentalist architecture (Sabel and Zeitlin 2010), and denigrated by others as a ‘red herring’ (Idema and Keleman 2006), the Open Method of Coordination (OMC) connects with major themes in EU politics and public policy, namely the Europe 2020 strategy for economic growth and competitiveness, the transformation of the
Stigmatization and labeling in society is one of the challenges that families of institutionalized children face. This research aims to investigate how professionals categorize the children and their families, and how, in turn, the categorization process impacts their daily practice and the relationship with families. The case study was conducted in a local children’s institution in Aalborg, Denma
Uncertainty during the course of a trip is regarded as a particularly disturbing phenomenon by public transport (PT) passengers and has been shown to have a substantial impact on travel behaviour. However, so far there has been little empirical evidence within contemporary research concerning the degree of mid- to long-term adaptation among PT passengers to changes in the principal cause of such u
Phylogenetic reconstruction of cancer cell populations remains challenging. There is a particular lack of tools that deconvolve clones based on copy number aberration analyses of multiple tumor biopsies separated in time and space from the same patient. This has hampered investigations of tumors rich in aneuploidy but few point mutations, as in many childhood cancers and high-risk adult cancer. He
