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Joint action without and beyond planning

Leading philosophical accounts of joint activity, such as Michael Bratman’s account of ‘shared intentional activity’, take joint activity to be the outcome of two or more agents having a ‘shared intention’, where this is a certain pattern of mutually known prior intentions (plans) that are directed toward a common goal. With Bratman’s account as a foil, I address two lacunas that are relatively un

Do socio-technical systems cognise?

The view that an agent’s cognitive processes sometimes include proper parts found outside the skin and skull of the agent is gaining increasing acceptance in philosophy of mind. One main empirical touchstone for this so-called active externalism is Edwin Hutchins’ theory of distributed cognition (DCog). However, the connection between DCog and active externalism is far from clear. While active ext

Disentangling The Thick Concept Argument

Critics argue that non-cognitivism cannot adequately account for the existence and nature of some thick moral concepts. They use the existence of thick concepts as a lever in an argument against non-cognitivism, here called the Thick Concept Argument (TCA). While TCA is frequently invoked, it is unfortunately rarely articulated. In this paper, TCA is first reconstructed on the basis of John McDowe

Dual Fuel Combustion of N-heptane/methanol-air-EGR Mixtures

Numerical simulations are performed to study the combustion processes of n-heptane and methanol/air/EGR under high-temperature and high-pressure conditions relevant to a dual-fuel compression-ignition engine. Detailed chemical kinetic mechanism and transport properties are considered in the simulation. The simulations are carried out by performing three-dimensional (3D) direct numerical simulation

Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease : large-scale collaborative study

Early genome-wide association (GWA) studies on Parkinson's disease (PD) have not been able to yield conclusive, replicable signals of association, perhaps due to limited sample size. We aimed to investigate whether association signals derived from the meta-analysis of the first two GWA investigations might be replicable in different populations. We examined six single-nucleotide polymorphisms (SNP

Large-scale replication and heterogeneity in Parkinson disease genetic loci

OBJECTIVE: Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown.METHODS: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium were invited to p

Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants

The best validated susceptibility variants for Parkinson's disease are located in the α-synuclein (SNCA) and microtubule-associated protein tau (MAPT) genes. Recently, a protective p.N551K-R1398H-K1423K haplotype in the leucine-rich repeat kinase 2 (LRRK2) gene was identified, with p.R1398H appearing to be the most likely functional variant. To date, the consistency of the protective effect of LRR

Biodiesel production from high acid value waste cooking oil using supercritical methanol: Esterification kinetics of free fatty acids

In this study, low quality waste cooking oil with high total acid value, has been used for biodiesel production. The main factors affecting the reaction has been analysed using Response Surface Methodology (RSM). A quadratic model representing the interrelationships between reaction variables and free fatty acids (FFA) conversion has been developed. Analysis of variance (ANOVA) has been used for c

Structural model of dodecameric heat-shock protein Hsp21 : Flexible N-terminal arms interact with client proteins while C-terminal tails maintain the dodecamer and chaperone activity

Small heat-shock proteins (sHsps) prevent aggregation of thermosensitive client proteins in a first line of defense against cellular stress. The mechanisms by which they perform this function have been hard to define due to limited structural information; currently, there is only one high-resolution structure of a plant sHsp published, that of the cytosolic Hsp16.9. We took interest in Hsp21, a ch

Writing, stitching, inking : Different modes of creating historical narratives

This article presents an analysis of different ways of producing historical narratives in the Swedish football environment. The examples are based on the activities around AIK, a top league football club from Stockholm. In the article I present a tifo and a tattoo, stitching and inking, as actual modes of writing history. Big clubs like AIK not only attract many fans, but also stimulate creative e

Organophilic pervaporation : Prospects and performance

Among the different membrane processes, organophilic pervaporation is one of the most promising technologies for environmental applications. The aim of this paper is to give a thorough introduction to organophilic pervaporation in the context of wastewater treatment. The emerging process of organophilic pervaporation is introduced together with other membrane processes relevant for environmental a

Use of pervaporation-bioreactor hybrid processes in biotechnology

Pervaporation is a membrane separation process with considerable innovative possibilities in the area of biotechnology. Above all, the combination of bioreactor and pervaporation has potential in the longer term as an alternative to conventional batch processes. This article considers the state of the art pervaporation-bioreactor hybrid processes. The possible applications of such hybrid processes

Integration of vacuum and sweep gas pervaporation to recover organic compounds from wastewater

Pervaporation with hydrophobic membranes has been widely recognised as a possible process to recover organic compounds from wasterwater. Compared to vacuum pervaporation, on which many researchers have focused, sweep gas pervaporation has received little attention. The aim of this study was to analyse opportunities for integrating and optimising both process layouts for the treatment of wastewater