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Endogenous vasopressin and vasopressin receptor 2 in bladder as anti-diuretic / anti-spasmodic targets for the treatment of multifactorial nocturia

Nocturia, the urge to wake from sleep to void, is targeted sub-optimally by existing drugs that modulate circadian dysregulation of urine production in kidney without alleviating detrusor overactivity, a key aspect in the multifactorial etiology of nocturia. This study reports age-related upregulation of arginine vasopressin (AVP) synthesis in mouse urinary bladder to counter the concurrent declin

The Swedish national guidelines on penile cancer

Objective: The Swedish national guidelines on penile cancer were first published in 2013. The objective of this study is to present the 2023 update of these guidelines and highlight the differences to the European Association of Urology (EAU) / American Association of Clinical Oncology (ASCO) guidelines on penile cancer. Material and methods: A review of the literature and a comparison to the EAU

Comparing Computational Peritoneal Dialysis Models in Pigs and Patients

Computational models of peritoneal dialysis (PD) are increasingly useful for optimizing treatment in patients with kidney disease requiring dialysis (KDRD). However, although several mathematical models have been developed in the past few decades, a direct comparison of the models’ accuracy with respect to predicting in vivo data is needed to further create robust personalized models. Here, we use

The sustainability reward : what does it take to undo climate ethical decisions in everyday life?

Today many of us strive to live as climate-friendly lives as possible, we stay informed with the ways that we can contribute and then try to alter our everyday habits accordingly. We often have an idea of what the best choice of transportation would be or that we should reduce our consumption in order to decrease our personal carbon footprint. Even with the best intentions our everyday-related dec

From Intensification to Sustainability? Political Leadership and Agricultural Transformation in Ethiopia

Ethiopia achieved a remarkable episode of agricultural intensification from the mid-1990s to the late-2010s, yet the political mechanisms that enabled this transformation—and the distributional and environmental consequences that followed—remain insufficiently understood. This article ex- amines how political leadership, understood in institutional rather than personalistic terms, shaped both the Ethiopia achieved a remarkable episode of agricultural intensification from the mid-1990s to the late-2010s, yet the political mechanisms that enabled this transformation—and the distributional and environmental consequences that followed—remain insufficiently understood. This article ex- amines how political leadership, understood in institutional rather than personalistic terms, shaped both the

Perspectives on conservation grazing : The need for monitoring and communication

Conservation grazing is widely used to manage open ecosystems, but inconsistent definitions and inadequate reporting of grazing patterns hinder effective communication among researchers, practitioners and policymakers, limiting the understanding and success of conservation grazing regimes. We demonstrate detailed measurement of the grazing pattern (comprising timing, intensity, duration and freque

Appropriate Reassessment : Events and Memory in the European Parliament 1995-2025

Historic events in motions for resolutions tabled by the parliament’s party groups between 1995-2025. While recent research trends within memory studies - under the influence of sociology - have tended to focus on agency, this thesis targets the content of memory politics by using historical research to confront political memories with their historical contexts. The thesis targets motions for reso

Vem är det som styr egentligen? : en studie om styrning i den enskilda järnvägsfrågan 1862–1875

Den här uppsatsen handlar om kommunalt självstyre, om besvärsmål, om enskilda järnvägar, om utvecklingen av svensk demokrati ur perspektivet av begreppet governance. Vi kommer titta på styrning på flera nivåer i det svenska samhället mellan 1860 och 1870 talet, av vissa forskare benämnd industrikapitalismen. En period där staten tog ett steg tillbaka och lämnade över delar av beslutsfattningen åt Who is Truly in Charge? A Study of Local Governance Regarding the Private Railway Question, 1862–1875. This paper examines the concept of governance by situating it within the historical context of Swedish municipal self-government between 1862 and 1875. Focusing on selected municipal appeal cases concerning decisions on the construction of private railways, the study tests the applicability of go

Characteristics of Children With Persistent Pain and Their Parents in a Tertiary Interdisciplinary Pain Clinic

Persistent Pain (PP) in children often has a high impact on their functioning. Knowledge about how to meet the needs is insufficient, especially regarding younger children, children with comorbid psychiatric health conditions, and within different national contexts. A specialized pediatric pain clinic for PP in Sweden offers assessment and interdisciplinary pain rehabilitation (IPR) and collects d

Distinct winter North Atlantic climate responses to tropical and extratropical eruptions over the last millennium in PMIP simulations and reconstructions

Large tropical (TROP) volcanic eruptions can influence North Atlantic climate by inducing a positive shift of the North Atlantic Oscillation (NAO), typically resulting in winter warming across northern Eurasia. However, these changes remain highly uncertain, as they may coincide with strong internal variability in Northern Hemisphere wintertime climate. In contrast, Northern Hemisphere extratropic

Building services and adaptive reuse : An overview of the regulations and potential in Swedish context

Adaptive reuse of buildings, repurposing existing structures for new functions, is gaining attention for its potential in sustainable development and optimisation of building materials usage. This practice is particularly relevant in the building sector, where space heating, ventilation, and air conditioning (HVAC) systems represent a significant portion of project costs, embodied energy, greenhou

Barriers and opportunities for dynamic adaptation of coastal railways

Railways are vital for climate mitigation as a low-carbon mode of transport but must also be resilient to climate change impacts. This study explores dynamic adaptation strategies for coastal railway infrastructure in Sweden, focusing on Trelleborg. Stakeholder workshops informed adaptation pathways using a Dynamic Adaptive Pathways Planning Light (DAPP)-light approach, which enhances stakeholder

Jitter Propagation in Task Chains

Chains of tasks are ubiquitous and used in a broad spectrum of applications. In these chains, tasks execute according to their timing. Then, they communicate by writing to and reading from shared memory. The schedule of tasks and the read/write instants are naturally subject to uncertainties (variability in the execution time, interference due to shared resources of higher priority tasks, etc.). D