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Introduction: Diabetes, as a chronic disease, is the third leading cause of death in developing countries. Hyperglycemia and oxidative stress have been recognized as the main factors involved in pathogenesis of diabetes. On the other hand, the antioxidant system is the first defense mechanism of body against oxidative stress. Falcaria Vulgaris possesses hypoglycemic and antioxidant effects. This s

Protective effect of Zingerone against mouse testicular damage induced by zinc oxide nanoparticles

The purpose of the present study was to evaluate the effect of Zingerone (Zing) on zinc oxide nanoparticle (ZNP)-induced spermatogenesis defects in mice. To this end, 50 mg/kg of ZNP was prescribed to the mice as an intoxicated group for 35 days. In protection groups, Zing (10, 20, and 40 mg/kg) was given prior to ZNP treatment for seven days and then co-administration of ZNP for 35 days. Epididym

Taurine effects on bisphenol a-induced oxidative stress in the mouse testicular mitochondria and sperm motility

Objectives: This study was performed to investigate the protective effects of taurine (2-aminoethanesulfonic acid, TAU) on oxidative stress in the isolated mouse testicular mitochondria, mitochondrial membrane potential (MMP), viability and motility of the exposed sperms to the BPA. Methods: We treated epididymal spermatozoa obtained from mice and isolated mouse testicular mitochondria with BPA (0

P-Coumaric acid alleviates adriamycin-induced hepatotoxicity in rats

Objective: To evaluate the effect of p-coumaric acid against adriamycin-induced hepatotoxicity in rats. Methods: The rats were divided into 4 groups. The control group received solvent; the p-coumaric acid group was treated with 100 mg/kg of p-coumaric acid orally for five consecutive days; the adriamycin group was administered with a single dose of adriamycin (15 mg/kg, i.p.), and the p-coumaric

Protective effects of selenium on bisphenol a-induced oxidative stress in mouse testicular mitochondria and sperm motility

Objective: This study aimed to explore the impact of selenium (SE) on Bisphenol-A (BPA)-exposed sperm and isolated testicular mitochondria of mice. Methods: Mouse sperm and isolated mitochondria were exposed to BPA (0.8 mM) and different concentrations of SE (50, 100, and 200 µM) for four hours. The viability of sperm and isolated mitochondria as well as the mitochondrial membrane potential (MMP)

A Faith for the Future : Why Traditional Religion Is the Preferable Form of Evolutionary Religion

In the philosophy of J. L. Schellenberg, “evolutionary religion” is a religious stance oriented towards the deep future. According to Schellenberg, the best form of evolutionary religion is non-doxastic faith in ultimism. I reject Schellenberg’s arguments for preferring ultimism and suggest that committing non-doxastically to traditional religion makes more sense from an evolutionary perspective.

Maskinkroppens gräns : Våld, immunitet och medieakologiska aggregationer i The Last of Us

This article examines the portrayal of bodily boundaries in the videogame series The Last of Us. Drawing on theories of media ecology and posthumanism (most notably Deer’s notion of radical animism, Haraway’s theories of the cyborg, and Fuller’s account of media assemblages), three aspects of this portrayal are described: first, the game’s narrativization of bodily violence through an amalgamation

Solution Structure of the dATP-Inactivated Class I Ribonucleotide Reductase From Leeuwenhoekiella blandensis by SAXS and Cryo-Electron Microscopy

The essential enzyme ribonucleotide reductase (RNR) is highly regulated both at the level of overall activity and substrate specificity. Studies of class I, aerobic RNRs have shown that overall activity is downregulated by the binding of dATP to a small domain known as the ATP-cone often found at the N-terminus of RNR subunits, causing oligomerization that prevents formation of a necessary α2β2 co

The Accumulating Costs Hypothesis—to Better Understand Delayed “Hidden” Costs of Seemingly Mild Disease and Other Moderate Stressors

Mild diseases and moderate stressors are seemingly harmless and are therefore often assumed to have negligible impact on Darwinian fitness. Here we argue that the effects of “benign” parasites and other moderate stressors may have a greater impact on lifespan and other fitness traits than generally thought. We outline the “accumulating costs” hypothesis which proposes that moderate strains on the

Measurements of the inclusive and differential production cross sections of a top-quark–antiquark pair in association with a Z boson at √s=13 TeV with the ATLAS detector

Measurements of both the inclusive and differential production cross sections of a top-quark–antiquark pair in association with a Z boson (tt¯ Z) are presented. The measurements are performed by targeting final states with three or four isolated leptons (electrons or muons) and are based on s=13 TeV proton–proton collision data with an integrated luminosity of 139 fb - 1, recorded from 2015 to 201

Mortality after surgery for primary hyperparathyroidism : results from a nationwide cohort

BACKGROUND: Contemporary patients with primary hyperparathyroidism are often diagnosed with mildly raised serum calcium levels. Previous studies have reported increased mortality in patients with primary hyperparathyroidism. This retrospective cohort study aimed to examine whether contemporary patients operated for primary hyperparathyroidism have higher mortality than the general population, and

Patterns and resectability of colorectal cancer recurrences : outcome study within the COLOFOL trial

BACKGROUND: Improvements in surgery, imaging, adjuvant treatment, and management of metastatic disease have led to modification of previous approaches regarding the risk of recurrence and prognosis in colorectal cancer. The aims of this study were to map patterns, risk factors, and the possibility of curative treatment of recurrent colorectal cancer in a multimodal setting. METHODS: This was a coh

Energy dependence of ϕ meson production at forward rapidity in pp collisions at the LHC

The production of ϕ mesons has been studied in pp collisions at LHC energies with the ALICE detector via the dimuon decay channel in the rapidity region 2.5 < y< 4. Measurements of the differential cross section d 2σ/ d yd pT are presented as a function of the transverse momentum (pT) at the center-of-mass energies s=5.02, 8 and 13 TeV and compared with the ALICE results at midrapidity. The differ

Determination of the parton distribution functions of the proton from ATLAS measurements of differential W± and Z boson production in association with jets

This article presents a new set of proton parton distribution functions, ATLASepWZVjet20, produced in an analysis at next-to-next-to-leading order in QCD. The new data sets considered are the measurements of W+ and W− boson and Z boson production in association with jets in pp collisions at s = 8 TeV performed by the ATLAS experiment at the LHC with integrated luminosities of 20.2 fb−1 and 19.9 fb

Crystallization of a Zr-based metallic glass produced by laser powder bed fusion and suction casting

The crystallization behaviour during low temperature annealing of samples of the Zr59.3Cu28.8Al10.4Nb1.5 (at%) bulk metallic glass produced by suction casting and the laser powder bed fusion (LPBF) process were studied with small angle neutron scattering (SANS), X-ray diffraction and scanning electron microscopy. The in-situ SANS measurements during isothermal annealing reveals that the phase sepa

Spatial analysis of domestic water use and rural livelihoods in a semi-arid African highland

Rural communities throughout sub-Sahara Africa are hampered by unequal access to water resources, economic markets, and transportation. Further, development programs do not always provide uniform access to water supply, especially in water scarce regions. With a growing concern over the limited supply of ecosystem services, the need to understand how the complex realities of water use is affected

Biodiversity decline with increasing crop productivity in agricultural fields revealed by satellite remote sensing

Increasing land-use intensity is a main driver of biodiversity loss in farmland, but measuring proxies for land-use intensity across entire landscapes is challenging. Here, we develop a novel method for the assessment of the impact of land-use intensity on biodiversity in agricultural landscapes using remote sensing parameters derived from the Sentinel-2 satellites. We link crop phenology and prod

Sodium hydrosulfide has no additive effects on nitrite-inhibited renal gluconeogenesis in type 2 diabetic rats

Objective: Increased renal and hepatic gluconeogenesis are important sources of fasting hyperglycemia in type 2 diabetes (T2D). The inhibitory effect of co-administration of sodium nitrite and sodium hydrosulfide (NaSH) on hepatic but not renal gluconeogenesis has been reported in rats with T2D. The present study aimed to determine the effects of co-administration of sodium nitrite and NaSH on the