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Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids

Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were i

The quantified consumer: blind, non-informed and manipulated?

Personal data is found at the core of the digital economy, and from a consumer perspective it is increasingly difficult to assess when it's collected, how it is utilised or traded and by what third parties it is handled over time. As Rhoen (2016) argues, a broader application of consumer protection regulation to user agreements may increase accountability for operators who collect and manage perso

Experimental and numerical analysis of spring stiffness on flow and valve core movement in pilot control globe valve

Valves are widely used for fluid flow control, not only for conventional fluid like water, gas and oil, but also for hydrogen under high pressure and so forth. Under these new conditions, the response time and energy consumption of valves are closely related to the whole performance of the piping system. Pilot-control globe valve (PCGV) is a novel quick response valve, which can utilize the pressu

Social exclusion modulates pre-reflective interpersonal body representation

Perception of an affordance is enhanced not only when the relevant object is located in one’s own peripersonal space, as compared to when it is located within extrapersonal space, but also when the object is located in another person’s peripersonal space (as measured by a Spatial Alignment Effect (SAE)). It has been suggested that this reflects the existence of an interpersonal body representation

Common Knowledge and Reductionism about Shared Agency

Most reductionist accounts of intentional joint action include a condition that it must be common knowledge between participants that they have certain intentions and beliefs that cause and coordinate the joint action. However, this condition has typically simply been taken for granted rather than argued for. The condition is not necessary for ensuring that participants are jointly responsible for

Tailoring Organic Cation of 2D Air-Stable Organometal Halide Perovskites for Highly Efficient Planar Solar Cells

2D perovskites have recently been shown to exhibit significantly improved environmental stability. Derived from their 3D analogues, 2D perovskites are formed by inserting bulky alkylammonium cations in-between the anionic layers. However, these insulating organic spacer cations also hinder charge transport. Herein, such a 2D perovskite, (iso-BA)2(MA)3Pb4I13, that contains short branched-chain spac

Role of biologics targeting type 2 airway inflammation in asthma : What have we learned so far?

Purpose of review Severe asthma is a heterogeneous syndrome that can be classified into distinct phenotypes and endotypes. In the type 2 (T2)-high endotype, multiple cytokines are produced that lead to eosinophilic inflammation. These cytokines and their receptors are targets for biologic therapies in patients with severe asthma who do not respond well to standard therapy with inhaled corticostero

Recovery-promoting factors in day centres and Clubhouses for people with psychiatric disabilities. A comparative study.

The thesis aims to compare two approaches to psychosocial rehabilitation – day centres and clubhouses – and to explore if either appears better suited to support people in mental health recovery. The recovery focus is on opportunities for engaging in meaningful daily occupations, accessibility to social interaction and factors pertaining to perceived health and well-being. The thesis consists of f

Membrane processes for water recovery and wastewater treatment in the food industry

Despite the efforts to reduce its water consumption, the food industry still requires large amounts of water. Membrane processes have established themselves in the food industry at the beginning of the water loop for preparation of the intake water and at the end water loop for recovery and final treatment of the water. The focus of this paper is on two application studies related to water recover

Observations made on the museums in Portici and on the Vesuvian sites by two Swedish professionals in 1756 and 1768, respectively

This article presents two formerly unedited travelaccounts, transcribed from the Swedish manuscripts and translated into English, narrating visits to Herculaneum, the Herculanense Museum and Pompeii, by Georg Fröman, Royal maçon, and Johan Tobias Sergel, sculptor, respectively. The texts are commented and put in historical context. Sergel's thorough accout of the Museum is read in parallel with th

On the diversity and richness of understory bryophytes at Nectandra Cloud Forest Reserve, Costa Rica

Background A survey of the understory bryophytes in the Nectandra Cloud Forest Preserve yielded 1083 specimens distributed among 55 families, represented by 74 genera of mosses, 75 genera of liverworts and 3 of hornworts. We studied and analyzed the bryophytic distribution on six types of substrates: 1) corticolous, 2) epiphyllous, 3) saxicolous, 4) terricolous, 5) aquatic and 6) lignicolous. The

EU Environmental Rights as Human Rights: Some Methodological Difficulties

This chapter highlights the methodological difficulties which stand in the way of interpreting EU law as granting a human right to a healthy environment.This chapter highlights the methodological difficulties which stand in the way of interpreting EU law as granting a human right to a healthy environment.

Neutron crystallography for the study of hydrogen bonds in macromolecules

The hydrogen bond (H bond) is one of the most important interactions that form the foundation of secondary and tertiary protein structure. Beyond holding protein structures together, H bonds are also intimately involved in solvent coordination, ligand binding, and enzyme catalysis. The H bond by definition involves the light atom, H, and it is very difficult to study directly, especially with X-ra

Relativistic Polarizable Embedding

Most chemistry, including chemistry where relativistic effects are important, occurs in an environment, and in many cases, this environment has a significant effect on the chemistry. In nonrelativistic quantum chemistry, a lot of progress has been achieved with respect to including environments such as a solvent or protein in the calculations, and now is the time to extend the possibilities for al

Measurement of jet fragmentation in Pb+Pb and pp collisions at √sNN=2.76 TeV with the ATLAS detector at the LHC

The distributions of transverse momentum and longitudinal momentum fraction of charged particles in jets are measured in Pb+Pb and pp collisions with the ATLAS detector at the LHC. The distributions are measured as a function of jet transverse momentum and rapidity. The analysis utilises an integrated luminosity of 0.14 nb- 1 of Pb+Pb data and 4.0 pb- 1 of pp data collected in 2011 and 2013, respe