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We present an efficient model for the simulation of polycrystalline materials undergoing solid to solid phase transformations. As a basis, we use a one-dimensional, thermodynamically consistent phase-transformation model. This model is embedded into a micro-sphere formulation in order to simulate three-dimensional boundary value problems. To solve the underlying evolution equations, we use a newly
Positron emission tomography (PET) with (18)F-FDG is a valuable tool for staging, planning treatment, and evaluating the treatment response for many different types of tumours. The correct volume estimation is of utmost importance in these situations. To date, the most common types of phantoms used in volume quantification in PET utilize fillable, hollow spheres placed in a circular or elliptical
Is overweight associated with impaired sperm DNA integrity?
Objectivity is central to many professions, ensuring legitimacy via impartiality and the detachment of emotional involvement. This article conducts an analysis of the emotion talk about objectivity in order to reveal and re-attach the emotions involved. This is achieved by determining how objectivity is presented in a profession viewed to be particularly objective namely the legal profession. Ther
Germline CDKN2A mutations are found in 5-20% of melanoma families. Numerous studies have shown that carriers of CDKN2A mutations have increased risks of non-melanoma cancers, but so far there have been no studies investigating cancer risks in CDKN2A wild type (wt) melanoma families. In this prospective cohort study, index melanoma cases (n = 224) and their first-degree relatives (n = 944) were ide
Actin dynamics in vascular smooth muscle is known to regulate contractile differentiation and may play a role in the pathogenesis of vascular disease. However, the list of genes regulated by actin polymerization in smooth muscle remains incomprehensive. Thus, the objective of this study was to identify actin-regulated genes in smooth muscle and to demonstrate the role of these genes in the regulat
Tasquinimod is an anti-tumor drug that is currently in clinical development for the treatment of solid cancers. After oral administration, tasquinimod and a number of its metabolites are excreted in the urine. The quantitative determination of tasquinimod in urine is challenging because of the required sensitivity (down to 0.1nM or 40pg/mL), the highly variable nature of this biological matrix and
Acute coronary syndromes (ACS) with narrow QRS are divided into 2 groups: ST-elevation ACS that requires emergency percutaneous coronary intervention, and non-ST elevation ACS. The classification of ACS into these 2 groups is not always straightforward. In this document, we discuss several electrocardiogram patterns of acute ischemia that are often misinterpreted. We suggest that any new recommend
Wall collision broadening of absorption lines of gases confined in porous media is a recently opened domain of high-resolution spectroscopy. Here, we present an experimental investigation of its application for pore size assessment. We report on the manufacturing of nanoporous zirconia ceramics with well-defined pore sizes fine-tuned from 50 to 150 nm. The resulting pore structure is characterized
Aim The aim of this study was to explore changes in motor function up to 10 years after selective dorsal rhizotomy (SDR). Method The participants comprised 29 children (20 males, nine females) with bilateral spastic diplegia who were consecutively operated on at a median age of 4 years and 3 months and followed until a median age of 15 years. SDR was combined with physiotherapy and regular follow-
Dendritic cells (DCs) operate as the link between innate and adaptive immunity. Their expression of pattern recognition receptors (PRRs), such as TLRs and CLRs, enable antigen recognition and mediate appropriate immune responses. Distinct subsets of human DCs have been identified; however their PRRs expressions are not fully clarified. Especially, expressions of CLRs by DC subpopulations remain el
PURPOSE: To examine the subsequent risk and prognosis of urological cancers among individuals diagnosed with autoimmune(AI) diseases. MATERIALS AND METHODS: We analyzed systematically the risk and prognosis of prostate, kidney and bladder cancers among individuals diagnosed with any of 33 different AI diseases based on nation-wide Swedish database covering years 1964 through 2008. Standardized inc
The extreme pressure resulting from modern-day disasters in terms of severe shortages of resources, mass casualties, infrastructure breakdown, large-scale damage and their impact necessitate coordination between all the agencies involved in disaster response. Better coordination in international disaster response operations will make them more effective in organizing the different phases of relief
The performance of six custom-built Hygrocopicity-Tandem Differential Mobility Analyser (H-TDMA) systems was investigated in the frame of an international calibration and intercomparison workshop held in Leipzig, February 2006. The goal of the workshop was to harmonise H-TDMA measurements and develop recommendations for atmospheric measurements and their data evaluation. The H-TDMA systems were co
Objective. The aim of this study was to test whether lower urinary tract symptoms (LUTS) and urinary incontinence are associated with the metabolic syndrome (MetS). The association between LUTS and benign prostatic enlargement (BPE) was also investigated. Material and methods. A cross-sectional, representative risk factor analysis of LUTS, as measured by the International Prostate Symptom Score (I
The development since the beginning of the 20th century of the pollen-analytical theory and method as a palaeoecological tool for describing landscape development is outlined with reference to southern Scandinavia. Numerical methods applied since the 1980s are discussed. The aim of this paper is to provide a new perspective on the landscape development and human impact during the Holocene by apply
A search for the decay of neutral, weakly interacting, long-lived particles using data collected by the ATLAS detector at the LHC is presented. This analysis uses the full data set recorded in 2012: 20.3 fb(-1) of proton-proton collision data at root s = 8 TeV. The search employs techniques for reconstructing decay vertices of long-lived particles decaying to jets in the inner tracking detector an
Although previous research has suggested that the opposition’s ability to form pre-electoral coalitions (PECs) in authoritarian elections is crucial for the electoral outcome, little has been written about why and when such coalitions are formed. The aim of this article is to fill this empirical and theoretical gap. A theory that combines oppositional parties’ office- and policy-gaining potential
Physiological studies on olfaction frequently ignore the airborne quantities of stimuli reaching the sensory organ. We used a gas chromatography-calibrated photoionization detector to estimate quantities released from standard Pasteur pipette stimulus cartridges during repeated puffing of 27 compounds and verified how lack of quantification could obscure olfactory sensory neuron (OSN) affinities.
