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Functional characterization of tRNA-derived small RNAs in stem cells
Transfer RNA (tRNA)-derived RNAs (tDRs) are abundant small RNAs with emerging roles in development and tumorigenesis. Increasing evidence indicates that tDRs regulate stem cell homeostasis and differentiation, often altered in disease, highlighting the importance of fully characterizing their role in stem cell biology. Multiple studies point to protein synthesis as a crucial target of tDR-mediated
Age at onset as an index of genetic heterogeneity in major psychiatric and substance use disorders
Background Robust clinical indices of etiologic heterogeneity for psychiatric disorders are rare. We investigate whether age at onset (AAO) reflects genetic heterogeneity, utilizing Genetic Risk Ratios (GRR) derived from Family Genetic Risk Scores (FGRS). Methods We examined, in individuals born in Sweden 1940-2003, whether AAO for five primary disorders - drug use disorder (DUD), alcohol use diso
Guidelines for the correct use of the nomenclature of biochemical indices of bone status : a position statement of the Joint IOF Working Group and IFCC Committee on Bone Metabolism
The presented guidelines are an update of the position paper, endorsed by the International Osteoporosis Foundation (IOF), on nomenclature of bone markers published over 2 decades ago. Novel insight into bone biology and pathophysiology of bone disorders has highlighted the increasing relevance of new and known mediators implicated in various aspects of bone metabolism. This updated guideline prop
Enhanced diffusion through multivalency
The diffusion of macromolecules, nanoparticles, viruses, and bacteria is essential for targeting hosts or cellular destinations. While these entities can bind to receptors and ligands on host surfaces, the impact of multiple binding sites—referred to as multivalency—on diffusion along strands or surfaces is poorly understood. Through numerical simulations, we have discovered a significant accelera
A two-phase epigenome-wide four-way gene–smoking interaction study of overall survival for early-stage non-small cell lung cancer
High-order interactions associated with non-small cell lung cancer (NSCLC) survival may elucidate underlying molecular mechanisms and identify potential therapeutic targets. Our previous work has identified a three-way interaction among pack-year of smoking (the number of packs of cigarettes smoked per day multiplied by the number of years the person has smoked) and two DNA methylation probes (cg0
Transcellular transport of 18F-deoxyglucose via facilitative glucose channels in experimental peritoneal dialysis
Background: Local and systemic side effects of glucose remain major limitations of peritoneal dialysis (PD). Glucose transport during PD is thought to occur via inter-endothelial pathways, but recent results show that phloretin, a general blocker of facilitative glucose channels (glucose transporters [GLUTs]), markedly reduced glucose diffusion capacity indicating that some glucose may be transfer
Methods and methodological challenges in the study of morphology in L2 French
Graffiti game boards at Gebel el-Silsila
10-årsjubileum för Lunds Didaktikseminarium för de moderna språken
Methodological considerations in the study of morphology in L2 French
Impact of Varying Velocities and Solvation Boxes on Alchemical Free-Energy Simulations
Alchemical free-energy perturbation (FEP) is an accurate and thermodynamically stringent way to estimate relative energies for the binding of small ligands to biological macromolecules. It has repeatedly been pointed out that a single simulation normally stays near the starting point in phase space and therefore underestimates the uncertainty of the results. Therefore, it is better to run an ensem
Armenia and Azerbaijan are at loggerheads again : here’s why tensions are rising
DISTRIBUTION OF LONG-CHAIN DIOLS IN THE BALTIC SEA AND ITS APPLICATION IN PALEOENVIRONMENTAL RECONSTRUCTION
Förändra synen på museiforskning
Review of As legend has it: history, heritage, and the construction of Swedish American identity.
Plats for liv och död : En etnologisk studie av kyrkogårdar och begravningsplatse
M. Moltesen & A. Rathje, eds, Approaches to Ancient Etruria (Danish Studies in Classical Archaeology. Acta Hyperborea 16), Charlottenlund: Museum Tusculanum Press 2022
Transforming crafts : A bottom-up perspective on religious change
10 fakta om universitetsstyrelsen och dess protokoll: visste du att...
Nedslag i historien kring Lunds universitets konsistorium/styrelse och dess protokoll.