Misfolding, self-assembly, and subsequent deposition of amyloid β plaques and tau tangles are closely associated with Alzheimer’s disease (AD) and its neurodegenerative processes, driving healthy neurons into a diseased state. At present, AD is the most widespread form of dementia, causing profound personal and familial hardship as well as imposing a substantial societal economic burden.Currently,The purpose of the work that forms the basis of this thesis has been to investigate fundamental properties of amyloid β and tau self-assembly and their solubility. The results of this research are presented as five research articles. In Paper I, a solubility assay for determining the solubility of amyloid proteins is developed and its use demonstrated for the Aβ40 peptide. Paper II finds that tau

The Collisional Orogeny in the Scandinavian Caledonides (COSC) project focuses on processes related to the closure of the Iapetus Ocean, causing the Ordovician–Silurian continent– continent collision between Baltica and Laurentia. The rock succession in the second drill core (COSC-2) from the Jämtland County, central Sweden, provides the base for detailed sedimentological, stratigraphic, geophysic

Reduced serum level of insulin-like growth factor 1 (IGF-1), a major regulator of perinatal development, in extremely preterm infants has been shown to be associated with neurodevelopmental impairment. To clarify the mechanism of IGF-1 transport at the blood–cerebrospinal fluid (CSF) barrier of the immature brain, we combined studies of in vivo preterm piglet and rabbit models with an in vitro tra

The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African cou

Håkan Hardenberger, conductor Orquesta Sinfónica de Tenerife, Ensemble Wind- and percussionworks included: Aaron Copland: Fanfare for the Common Man (1942) Irene Raquel Fariña: PhidiasErnst Krenek: Kleine Blasmusik, op. 70a IntervalEinojuhani Rautavaara: A Requiem in Our Time (1953)Antonin Dvořák: Serenade für Bläserensemble d-Moll op. 44

Andris Nelsons conducts and Håkan Hardenberger is soloist in a new trumpet concerto. Programme: Jörg Widmann Towards Paradise (Labyrinth VI) for trumpet and orchestra37 minEncore:Richard Rodgers My Funny Valentine, version for trumpet solo arr Håkan Hardenberger3 minPjotr Tjajkovskij Symphony No. 442 min

Det förvaltningsrättsliga landskapet i Sverige har under de senaste decennierna blivit allt mer sammanlänkat med Europarätten, dvs. EU-rätten, Europakonventionen samt annat material från Europarådet. För att som svensk jurist kunna arbeta med förvaltningsrättsliga frågor är det nödvändigt att ha en grundläggande förståelse för hur Europarätten påverkar de svenska rättsliga strukturerna. I verket p

Aims: The left atrial appendage (LAA) produces natriuretic peptides and its removal or occlusion might increase the risk of heart failure (HF). We aimed to investigate the incidence of HF after LAA occlusion or removal (LAAO) in the Left Atrial Appendage Occlusion Study (LAAOS III). Methods and results: Patients (n = 4811) with atrial fibrillation (AF) and a CHA2DS2-VASc score ≥2, who were having

Objective We investigated associations between bioaerosol exposures and work-shift changes in lung function and inflammatory markers among recycling workers. Methods Inhalable dust was measured with personal samplers and analyzed for endotoxin, bacteria, and fungi (incubated at 25 °C and 37 °C) levels. Lung function (FEV1, FVC) was measured before and after work-shifts and serum concentrations of

After the COVID-19 pandemic, during which teachers developed a lot of online course material, teachers worldwide are challenged with how to combine online teaching with classroom teaching in an efficient way. This paper presents Discussion seminars, a teaching activity that structures discussions clearly, making it easy for students and teachers to follow the discussion. The paper puts Discussion

Many governments worldwide have proposed transitioning from a fossil-based economy to a bioeconomy to address climate change, resource depletion, and other environmental concerns. The bioeconomy utilizes renewable biological resources across all sectors and is strongly founded on scientific advances and technological progress. Given that the bioeconomy spans multiple sectors, industries, and techn

Programme:Jörg Widmann Towards Paradise (Labyrinth VI)*Gustav Mahler Symphony No 5The trumpet concerto “Towards Paradise (Labyrinth VI)” was especially written for Håkan Hardenberger (21/22) by composer Jörg Widmann.

Extreme solar particle events (ESPEs) are infrequent yet highly potent manifestations of solar activity. These events result in the production of significant amounts of cosmogenic isotopes (CIs): 10Be, 36Cl, and 14C, which are subsequently deposited in natural stratified archives. Analyzing CI measurements from these archives allows us to assess the particle fluxes during ESPEs. In this study, we

Pulmonary veno-occlusive disease (PVOD) is a lethal variant of pulmonary hypertension. The degree of pulmonary arterial involvement varies. Here, we compare two PVOD patients who were transplanted at 8 years of age, whereof one is a homozygous EIF2AK4 mutation carrier. Tissue was imaged with synchrotron-based micro-CT and the results were compared with clinical data and sectioned tissue was analyz

The extent to which bullying victimization is associated with an increased risk of obsessive-compulsive disorder (OCD) has received little empirical attention. This longitudinal, population-based, genetically informative study examined whether self-reported bullying victimization at age 15 was associated with a clinical diagnosis of OCD in the Swedish National Patient Register and with self-report

Transverse momentum pT spectra and anisotropic flow distributions are studied for charmonia and charmed hadrons produced in Pb-Pb collisions and measured with the ALICE detector at the CERN Large Hadron Collider (LHC). The investigations are performed within the framework of the Statistical Hadronization Model with the transverse dynamics evaluated using predictions from relativistic viscous hydro