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Deep learning analysis of serial digital breast tomosynthesis images in a prospective cohort of breast cancer patients who received neoadjuvant chemotherapy
Purpose: Different imaging tools, including digital breast tomosynthesis (DBT), are frequently used for evaluating tumor response during neoadjuvant chemotherapy (NACT). This study aimed to explore whether using artificial intelligence (AI) for serial DBT acquisitions during NACT for breast cancer can predict pathological complete response (pCR) after completion of NACT. Methods: A total of 149 wo
Obesity and its association with self-efficacy and metabolic risk factors by region of birth among 40-year-olds participating in the Swedish targeted health dialogues
Objective: Targeted Health Dialogues (THD) is a public health intervention program that aims at preventing cardiovascular disease. THDs were implemented in the Swedish region Scania, in 2020, with the novelty of being conducted in a metropolitan area with a multiethnic population. This study investigated the prevalence of obesity among 40-year-old THD participants in Scania by region of birth, and
Survivors benefits in Sweden: Social Security Developments, Collective Agreements and Gender Aspects
Optimizing the hydraulic power take-off system in a wave energy converter
This study aims to determine the optimal pressure for the accumulator tank in a wave energy converter (WEC) with hydraulic power take-off (PTO) to maximize energy generation. A simulation-based approach was employed to analyze the buoy's performance with wave data generated from the Wafo toolbox using the generalized Pierson–Moskowitz (GPM) spectrum. These data were then fed into a Simulink model
Application-based evaluation of multi-basin hydrological models
Hydrological models are generally calibrated and validated using a suite of well-known statistical metrics, which sometimes lack clear connection and tailoring to the local users’ need and therefore limits the evaluation, especially in the case of global climate services. Therefore, in this study, two types of application-based evaluation metrics are introduced, addressing (i) temporal matching of
Om sorgen, omsorgen och ett värdigt liv
Towards the exact complexity of realizability for Safety LTL
We study the realizability and strong satisfiability problems for SAFETY LTL, a syntactic fragment of Linear Temporal Logic ([Formula presented]) capturing safe formulas. While it is well-known that realizability for this fragment lies in [Formula presented], the best-known lower bound is [Formula presented]-hardness. Surprisingly, closing this gap has proven an elusive task. Previous works have c
The Early Perfusion Image Is Useful to Support the Visual Interpretation of Brain Amyloid-PET With 18F-Flutemetamol in Borderline Cases
Purpose Visual interpretation of brain amyloid-β (Aβ) PET can be difficult in individuals with borderline Aβ burden. Coregistration with individual MRI is recommended in these cases, which, however, is not always available. This study evaluated coregistration with the early perfusion frames acquired immediately after tracer injection to support the visual interpretation of the late Aβ-frames in PE
Iron-rich Ca–Mg skarns from the SW East European Craton (Lithuania) : Microstructural study, mineral reactions and direct age constraints of ore-forming events using LA-ICPMS
The Varena Iron Ore deposit in the SW East European Craton is a significant ore body that occurs within metamorphosed and hydrothermally reworked Paleoproterozoic dolostones. We have performed microstructural investigations supplemented with mineral chemistry and geochronological investigations (LA-ICP-MS) to obtain age constraints on the ore-forming event(s) and improve the understanding of the c
Climate change dominated runoff change in the eastern Tibetan Plateau
Quantitatively identifying the impact of climatic and underlying surface condition changes on runoff is crucial for the efficient utilization of water resources and understanding hydroclimatic variability processes. This study aims to employ both Grid-RCCC-WBM model and Fu's equation based on Budyko hypothesis to quantitatively analyze the spatial patterns of runoff changes, driving forces, and up
Older employees, extended working lives, and collective bargaining
L-chondrite body breakup in Ordovician strata in China - A time tie point globally and across the inner solar system
More than a quarter of all meteorites falling on Earth today originate from the breakup of the L-chondrite parent body (LCPB) ∼470 Ma ago, the largest documented asteroid breakup in the past ∼3 Ga. The event had a profound impact on the inner Solar System, resulting in an orders-of-magnitude increase in L-chondritic material in mid-Ordovician sediments on Earth. Here we show based on Ordovician st
Zinc speciation in fly ash from MSWI using XAS - novel insights and implications
The chemical forms of zinc in fly ash from municipal solid waste incineration (MSWI) crucially affect ash management, influencing both material recovery options and the risk of unwanted leaching into ecosystems. The zinc speciation was investigated in fly ash samples sourced from full-scale MSWI plants, including four grate fired boilers (GB) and one fluidized bed boiler (FB). We applied X-ray Abs
Projekt hälso- och sjukvårdsuppföljning: jämlik vård : Slutrapport
Project report from Region Skåne, investigating how to improve evaluations of healthcare quality and equity in Region Skåne. Project duration 2022-2024.
Gender and Care between Bonus/step-grandparents and bonus/step-grandchildren
Almost half of all divorced Swedes are aged 60+ and many of them are, or have been, part of a reconstituted family. This increases the probability of having (or to be a) bonus/step-grandchild and raises the question: How does the caregiving dynamic between bonus-grandparents and bonus-grandchildren intersect with gender and life situation, unraveling the intricate threads that weave through familiAlmost half of all divorced Swedes are aged 60+ and many of them are, or have been, part of a reconstituted family. This increases the probability of having (or to be a) bonus/step-grandchild and raises the question: How does the caregiving dynamic between bonus-grandparents and bonus-grandchildren intersect with gender and life situation, unraveling the intricate threads that weave through famili
Neuronal and glial responses to dopaminergic denervation
Parkinson's disease (PD) is characterised by severe degeneration of dopamine (DA) neurons innervating the striatum. Spiny projection neurons (SPNs), are the principal type of striatal neuron and belong to either of two classes: the D2 receptor-positive indirect pathway SPNs (iSPNs) and the D1 receptor-positive direct pathway SPNs (dSPNs). The thesis aims at investigating dynamic changes of SPNs an
Multiple Structural Breaks in Interactive Effects Panel Data Models
Practices, strategies, and challenges in antibiotic treatment and prevention of antimicrobial resistance from the perspectives of Romanian community pharmacists and general practitioners: a Goffman-inspired qualitative interview study
Introduction: Antimicrobial resistance (AMR) represents a persistent and ascensive global threat influenced by antibiotic misuse and overuse. In the Romanian context, patterns of antibiotic consumption and resistance within the healthcare system are marked in the red scenario on the European map. General practitioners and pharmacists, among others, play a major role in stewardship towards AMR.Aim:
Association of ventricular-arterial coupling with biomarkers involved in heart failure pathophysiology - the STANISLAS cohort
AIMS: Impaired left ventricular-arterial coupling (VAC) has been shown to correlate with worse prognosis in cardiac diseases and heart failure (HF). The extent of the relationship between VAC and circulating biomarkers associated with HF has been scarcely documented. We aimed to explore associations of VAC with proteins involved in HF pathophysiology within a large population-based cohort of middl