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Development and validation of robust molecular biomarkers has so far been limited in melanoma research. In this paper we used a large population-based cohort to replicate two published gene signatures for melanoma classification. We assessed the signatures prognostic value and explored their biological significance by correlating them with factors known to be associated with survival (vitamin D) o
Hela 122 nya arter för Blekinge – varav åtta även nya för Sverige – har hittats sedan Blekinges flora kom ut 2006. Lars Fröberg presenterar här den digra fyndlistan.
Cardiolipin is a phospholipid found in the inner mitochondrial membrane and in bacteria, and it is associated with many physiological functions. Cardiolipin has a dimeric structure consisting of two phosphatidyl residues connected by a glycerol bridge and four acyl chains, and therefore it can carry two negative charges. The pKa values of the phosphate groups have previously been reported to diffe
Caldicellulosiruptor saccharolyticus has gained reputation as being among the best microorganisms to produce H2 due to possession of various appropriate features. The quest to develop an inexpensive cultivation medium led to determine a possible replacement of the expensive component cysteine, i.e. sulphate. C. saccharolyticus assimilated sulphate successfully in absence of a reducing agent withou
We construct small-amplitude periodic water waves with multiple critical layers. In addition to waves with arbitrarily many critical layers and a single crest in each period, multimodal waves with several crests and troughs in each period are found. The setting is that of steady two-dimensional finite-depth gravity water waves with vorticity.
In this paper we provide necessary and sufficient conditions for strongly group graded rings to be simple. For a strongly group graded ring R the grading group G acts, in a natural way, as automorphisms of the commutant of the neutral component subring R_e in R and of the center of R_e. We show that if R is a strongly G-graded ring where R_e is maximal commutative in R, then R is a simple ring if
During excavations at Uppakra in Scania, Sweden, an exceptional copper alloy mount in the shape of a winged human was found. The figure is unique not only in its exquisite craftsmanship, but also in its iconography. It is argued that the mount was made in the loth century AD and that it depicts Wayland the Smith.
I argue that an evolutionary adaptation for bodily mimesis, the volitional use of the body as a representational devise, is the “small difference” that gave rise to unique and yet pre-linguistic features of humanity such as (over)imitation, pedagogy, intentional communication and the possibility of a cumulative, representational culture. Furthermore, it is this that made the evolution of language
The 18th century witnessed profound changes in the political thinking of Western societies regarding the individual, society and the state. The principle of freedom of religion was confirmed in the American Declaration of Independence in 1776 and in the French Declaration of the Rights of Man and of the Citizen in 1789. A guiding principle was that the civic rights of individuals were not to be de
Sperm number is often a good predictor of success in sperm competition; however, it has become increasingly clear that, for some species, variation in probability of paternity cannot be explained by sperm number alone. Intraspecific variation in ejaculate characteristics, such as the number of viable sperm and sperm longevity, may play an equally important role in determining fertilization success
Knowledge of interrater reliability in the evaluation of perfusion computed tomography (CTP) studies is very limited even though the method is widely used in the workup of acute stroke. The aims of this study were to estimate the inter- and intraolbserver agreement in the evaluation of CTP data and to evaluate the feasibility of the method. The CTP data of 20 consecutive patients (50% were females
We introduce a dengue model (SEIR) where the human individuals are treated on an individual basis (IBM) while the mosquito population, produced by an independent model, is treated by compartments (SEI). We study the spread of epidemics by the sole action of the mosquito. Exponential, deterministic and experimental distributions for the (human) exposed period are considered in two weather scenarios
Background: Respiratory agents may be detected in the oropharynx of healthy individuals. The extent of this condition and the reasons behind it are largely unknown. The objective of this study was to determine the factors associated with the presence of respiratory agents in the oropharynx of adolescents healthy enough to attend school activities. Methods: On a single day in December, samples from
Permafrost in peatlands of subarctic Sweden is presently thawing at accelerated rates, which raises questions about the destiny of stored carbon and nutrients and impacts on adjacent freshwater ecosystems. In this study we use peat and lake sediment records from the Stordalen palsa mire in northern Sweden to address the late Holocene (5,000 cal BP-present) development of the mire as well as relate
The psychometric properties of the Swedish self-report version of the Strengths and Difficulties Questionnaire (SDQ-s), and the prevalence of emotional and behavioral problems as measured by the SDQ-s, were studied in 14 to 15-year-old adolescents. The psychometric properties were found to be similar to those found in other language versions, in terms of similar factor structure and acceptable tes
Inherited mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose carriers to breast and ovarian cancer. The authors have identified a mutation in BRCA2, 7845+1G > A (c.7617+1G > A), not previously regarded as deleterious because of incorrect mapping of the splice junction in the originally published genomic reference sequence. This reference sequence is generally used in many laborator
Johansson BB. Current trends in stroke rehabilitation. A review with focus on brain plasticity. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2010.01417.x. (c) 2010 John Wiley & Sons A/S. Current understanding of brain plasticity has lead to new approaches in ischemic stroke rehabilitation. Stroke units that combine good medical and nursing care with task-oriented intense training in an environm
