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Objective: Severe obesity poses a major public health concern due to its links with cardiometabolic complications and mortality. Visceral adipose tissue (VAT) plays a key role in these processes through distinct molecular features. This study aimed to characterize the VAT proteome of individuals with severe obesity and investigate its association with serum metabolic biomarkers. Methods: A cross-s
Den demografisk utveckling i flera länder medverkar till att allt fler kommer att behöva arbeta tillen högre ålder i framtiden. Det kommer alltså att fler äldre i arbetslivet i framtiden. Arbetslivet ärunder ständig utveckling och förändring. En del äldre arbetsmiljöproblem har försvunnit, andrakvarstår, samtidigt som ny ständigt uppstår. Hur och vad som påverkar arbetstagare i olika åldrarbehöver
INTRODUCTION: The rapid digitalisation of workplaces presents both challenges and opportunities for older workers. This scoping review examines how digital technologies impact social support for older workers, focusing on emotional, informational, and instrumental support within professional environments. While social support is critical for well-being and productivity in ageing workforces, the ef
Understanding human adaptations under varying scenarios is a critical concern from the earliest stages of system design. This study develops within the context of Advanced Air Mobility (AAM) and examines human performance variability during simulated drone operations using the Event Analysis of Systemic Teamwork (EAST) method. The analysis focuses on bird strike events that each of the five partic
Background: Fine-needle aspiration biopsy (FNAB) of lymph nodes is a widely used method for evaluating lymphadenopathy. FNAB offers general advantages of rapid turnaround time, low cost and minimal morbidity, and more specific advantages in various clinical situations, such as deeply located lymph nodes or patients with significant comorbidities. The FNAB sample can be utilized for a wide range of
Background: Low lung function has been consistently associated with increased cardiovascular disease (CVD) risk, with emerging evidence suggesting a potential causal relationship. However, underlying biological mechanisms remain unclear. Aim: To investigate relationships between CVD-associated plasma proteins and lung function. Methods: We analysed plasma protein profiles in two Swedish population
Background: Transcatheter aortic valve replacement (TAVR) is increasingly used in patients with bicuspid aortic valve (BAV) stenosis, but there is limited comparative data on balloon-expandable (BEV) versus self-expanding valves (SEV) in this population. Aim: To compare clinical and hemodynamic outcomes between BEVs and SEVs in patients with BAV stenosis. Methods: This observational cohort include
Stiffening of tissue is a hallmark of cancer progression, promoting invasive phenotypes through altered cell-extracellular matrix (ECM) interactions. However, how fully formed epithelial structures respond to mechanical cues within their native ECM environment remains poorly understood. Here, using a 3D in situ stiffening hydrogel system that enables modulation of stiffness around mature normal ma
The continued reliance on cars presents a challenge for sustainable mobility policy. A wide range of approaches exists to address this issue, from promoting more sustainable vehicle options to replacing cars altogether. However, national sustainable mobility policies related to car use often suffer from spatial blindness–which implies a limited contextual differentiation based on the specific char
Background: People with intellectual disabilities experience significant health inequities. Digital interventions for health promotion are rarely designed from their specific needs. This study aimed to uncover core qualities of digital interventions for health promotion by exploring factors influencing health behaviours amongst people with intellectual disabilities. Methods: This study was conduct
Purpose – Our research examines the impact of Islamic religiosity, exploring the role of religious actors, religious ideas (knowledge-based religiosity) and religious practice, on the involvement in early-stage entrepreneurial activity at the provincial level in Indonesia. Design/methodology/approach – We rely on the survey conducted by Global Entrepreneurship Monitoring in Indonesia, spanning fro
Chemical vapour deposition enables large-domain growth of ideal graphene, yet many applications of graphene require the controlled inclusion of specific defects. We present a one-step chemical vapour deposition procedure aimed at retaining the precursor topology when incorporated into the grown carbonaceous film. When azupyrene, the molecular analogue of the Stone-Wales defect in graphene, is used
IMPORTANCE COVID-19 can lead to long-term cardiopulmonary symptoms and is associated with coronary microvascular dysfunction (CMD). However, long-term data on CMD after severe COVID-19 are lacking. OBJECTIVE To investigate long-term left ventricular function and the presence of CMD after severe COVID-19. DESIGN, SETTING, AND PARTICIPANTS This case-control study was conducted among patients at a si
Background Although the role of smoking as a risk factor for emphysema in α1-antitrypsin deficiency (AATD) is well known, never-smokers with severe AATD may also develop lung disease, ranging from mild asymptomatic disease to severe emphysema. Methods We performed a cross-sectional and observational study to analyse the characteristics of the population of never-smoker severe AATD (genotype) indiv
Background: Despite recommendations by EU, surveillance of Lyme neuroborreliosis (LNB) is still not fully implemented in all member states, Sweden being one of them. Laboratory-based notifications on positive Borrelia antibody index (AI) in paired cerebrospinal fluid-serum samples alone have been suggested for surveillance of LNB. Objectives: We aim to describe the epidemiology of Lyme borreliosis
This study presents a detailed simulation-based analysis of the detection limits of multi-element monolithic Germanium (Ge) detectors to cadmium traces in environmental soil samples. Using the capabilities of the Geant4 Monte Carlo toolkit in combination with the Solid State Detector Package, we evaluated the detection limit variation with the sample-to-detector distances and photon flux. These si
Objectives: This study aimed to assess the relationship between dietary intake and disease outcomes in patients with radiographic axial spondyloarthritis (r-axSpA), focusing on inflammation and disease activity, while also evaluating other health outcomes, and to compare dietary intake between patients and controls. Method: In a cross-sectional analysis, we studied 295 patients with r-axSpA (modif
Background: Studies in breast cancer patients have consistently shown that physical activity improves survival. We examined if change in physical activity from before to after a breast cancer diagnosis is associated with outpatient specialist care use and hospitalisations in women with type 2 diabetes mellitus (T2DM). Methods: This register-based cohort study included 2145 women with T2DM who self
Background: The recommended treatment for hyposmia (a clinically reduced sense of smell) is olfactory training using odor containers that the patients smell twice a day for several weeks. Adherence to the olfactory training regimen is, however, generally low. We aimed to investigate if a new form of odor delivery, using scented nasal inserts, could enhance adherence to olfactory training by allowi
The chapter examines the flourishing hagiographical production during the Macedonian age, a period marked by intense rewriting of earlier Greek hagiography. This rewriting culminated in the Metaphrastic menologion, compiled by Symeon Metaphrastes in the late tenth century. Following the end of the iconoclastic controversy until Symeon, a clear progression is attested from an initial monastic inter
