Agricultural ecosystems are important for regulating terrestrial hydrological and carbon cycles. Hydrological and carbon processes in agricultural ecosystem models are complex due to interactions between parameters. It is therefore crucial to identify parameter sensitivity before a process-based model is applied for simulations and predictions of water, energy and carbon fluxes in agricultural ec

Trust is a key mechanism for explaining the ease and frequency of knowledge spillovers within regions. While the importance of trust is virtually uncontested, there have been few attempts to rigorously disentangle the way in which trust formation is related to space and proximity. The aim of this paper is to advance the understanding of trust formation in terms of its main antecedents within the c

The digestion of choline phospholipids is important for choline homeostasis, lipid signaling, postprandial lipid and energy metabolism, and interaction with intestinal bacteria. The digestion is mediated by the combined action of pancreatic and mucosal enzymes. In the proximal small intestine, hydrolysis of phosphatidylcholine (PC) to 1-lyso-PC and free fatty acid (FFA) by the pancreatic phospholi

Aims: To study the association between baseline level of C-peptide and all-cause death, cardiovascular death and cardiovascular complications among persons with newly diagnosed type 2 diabetes. Methods: The Skaraborg Diabetes Register contains data on baseline C-peptide concentrations among 398 persons

We present a theoretical investigation providing key insights on a long-standing controversial issue that dominated the debate on carbon monoxide oxidation by Mo–Cu CO-dehydrogenases. Previous investigations gravitate around the possible occurrence of a thiocarbonate intermediate, that was repeatedly reported to behave as a thermodynamic sink on the catalytic energy landscape. By using a hierarchy

4-Quinolones affect mammalian cellular functions in vitro in several ways. High concentrations inhibit DNA replication, but individual genes are perhaps sensitive to lower concentrations of drug. Inhibition of cell proliferation differs widely among 4-quinolones. Ciprofloxacin and norfloxacin are the most antiproliferative, inhibiting cell growth by -30% at 20 mg/L. Genotoxicity tests with 4-quino

The effects of different 4-quinolone antibiotic derivatives (4-Qs) in a number of short-term tests commonly employed for the evaluation of genetic toxicity were studied. Incorporation of [3H]thymidine into mitogen-stimulated peripheral blood lymphocytes was strongly enhanced at a low concentration (1.56 μg/ml) for most of the tested 4-Qs, whereas DNA strand breakage in lymphoblastoid cells was evi

Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross

The fluoroquinolone antibiotic ciprofloxacin (cipro) has been reported to upregulate interleukin 2 and interferon-γ production in lectin-stimulated lymphocytes. The aim of this study was to elucidate whether cipro and the immunosuppressive agent CsA have antagonistic action on cytokine synthesis. Accumulation of IL-2 and IFN-γ protein and mRNA were analyzed in polyclonally (PHA or Con A) or alloan

Kolloider, partiklar i storleksordningen en nanometer till en mikrometer, är inom materialvetenskapen attraktiva byggstenar vid konstruktion av olika material eftersom de spontant organiserar sig i periodiska strukturer. Till skillnad från biologiska kolloider såsom proteiner, röda blodkroppar, bakterier och virus, är de syntetiska kolloider som man har tillgång till inom materialvetenskapen i regColloidal self-assembly is an attractive bottom-up approach to new superstructures and materials with new properties. However, the typical spherical shape and isotropic interaction potential limit the repertoire of ordered structures that can be obtained from synthetic colloids. In order to expand the repertoire of structures, much effort has over the last decades been directed towards the prepara

Background: Recently, the block-sequential regularized expectation maximization (BSREM) reconstruction algorithm was commercially introduced (Q.Clear, GE Healthcare, Milwaukee, WI, USA). However, the combination of noise-penalizing factor (β), acquisition time, and administered activity for optimal image quality has not been established for 18 F-fluorocholine (FCH). The aim was to compare image

Computer science plays a major role in image segmentation and image processing applications. Despite the computational cost, PSO evaluated QCA approaches perform comparable to or better than their crisp counterparts. This novel approach, proposed in this chapter, has been found to enhance the functionality of the CA rule base and thus enhance the established potentiality of the fuzzy-based segment