BACKGROUND: Human stem cells are viewed as a possible source of neurons for a cell-based therapy of neurodegenerative disorders, such as Parkinson's disease. Several protocols that generate different types of neurons from human stem cells (hSCs) have been developed. Nevertheless, the cellular mechanisms that underlie the development of neurons in vitro as they are subjected to the specific differe

High-energy heavy-ion collisions provide a unique tool for the study of nuclear matter as a function of temperature and density. WA98 at the CERN SPS recorded data with a 158 A GeV Pb beam on a Pb target in 1996. To cope with the high charged-particle density, a tracking system based on high granularity multi-step avalanche detectors was developed. The results from the first measurement of Delta++

The PITX family of transcription factors regulate the development of many organs. Pitx1 mutants have a mild pituitary phenotype, but Pitx2 is necessary for the development of Rathke's pouch, expression of essential transcription factors in gonadotropes, and expansion of the Pit1 lineage. We report that lack of Pitx2 causes the pouch to undergo excessive cell death, resulting in severe pituitary hy

Popular Abstract in Swedish Vilka egenskaper var det som gjorde just pesten så fruktad av alla sjukdomar? Hur skiljde den sig från andra samtidigt grasserande farsoter? Hur spreds den? Och hur passade den in i dåtidens samhälle socialt och kulturellt? Det är några av de frågor som denna undersökning med fokus på Skåne 1710 - 1713 vill besvara. Mycket är fortfarande oklart om hur pesten uppträdde This study deals with Sweden’s last outbreak of the plague with focus on Skåne, where the epidemic raged for three years - from late autumn 1710 to late autumn 1713. This was a time of war, crop failures as well as other simultaneously occurring epidemics. The outline of this study can be summarised with the following points: This is the first regional analysis of plague in Skåne. All preserved b

Persistent organochlorine pollutants (POPs) are suspected to interfere with hormone activity and the normal homeostasis of spermatogenesis. We investigated the relationships between sperm DNA fragmentation, apoptotic markers identified on ejaculated spermatozoa and POP levels in the blood of 652 adult males (200 Inuits from Greenland, 166 Swedish, 134 Polish and 152 Ukrainian). Serum levels of 2,

Human fibroblast and leukocyte interferons were found to suppress lymphocyte mitogenesis induced by optimal doses of phytohemagglutinin and concanavalin A. In certain situations (low doses of mitogen and/or low doses of interferon), however, interferon significantly enhanced mitogenesis. In experiments using varying concentrations of interferon, dose-response curves with different slopes were obta

Popular Abstract in Swedish I studier rörande de yngsta barnen saknas ofta genusperspektiv. Ett syfte med studien var därför att undersöka interaktionen mellan barnen (1-3 år gamla) och förskolepersonalen på småbarnsavdelningarna vid tre förskolor i ett genus- och kontextuellt perspektiv. Ett annat syfte var att undersöka pedagogernas föreställningar om barn och genus. Ett tredje syfte var att disIn studies concerning the youngest children, the toddlers, the gender perspective is often missing. One aim of the study was, therefore, to investigate the interaction between children and preschool teachers in day care centres in a gender and a contextual perspective. Another aim was to investigate the inner representations of the preschool teachers concerning children and gender. A third aim was

Objectives To explore case ascertainment, hospitalization, characteristics of both hospitalized and non-hospitalized patients in a population-based group of stroke patients. Materials and methods One-year screening in Lund-Orup district for first-ever strokes using multiple prospective and retrospective methods. Results A total of 456 patients with first-ever stroke (n = 412 prospective screening

The coordination environment of uranyl in water has been studied using a combined quantum mechanical and molecular dynamics approach. Multiconfigurational wave function calculations have been performed to generate pair potentials between uranyl and water. The quantum chemically determined energies have been used to fit parameters in a polarizable force field with an added charge transfer term. Mol

AimsTo examine determinants for glycaemic control in primary care patients with Type 2 diabetes. MethodsIn a community-based surveillance of primary care patients with Type 2 diabetes, 190 men and 186 women were consecutively identified and examined for cardiovascular risk factors. Insulin resistance and beta-cell function were estimated using homeostasis model assessment (HOMA). Good glycaemic c

Background: Funding organisations and research ethics committees (RECs) should play a part in strengthening attention to gender equality in clinical research. In the research policy of European Union (EU), funding measures have been taken to realise this, but such measures are lacking in the EU policy regarding RECs. Objective: To explore how RECs in Austria, Germany, Ireland, The Netherlands and

Currently, a single ion hit facility, for irradiation of single cells with single, light MeV ions is under development at the Lund Nuclear Microprobe. In this paper, a novel approach to the ion detection issue is presented. A silicon detector, a type utilized at other facilities for post-cell ion detection, has been investigated as a possible option for pre-cell hit detection. If proven successful

Bygg rätt från början är ett centralt motto om man vill bygga ett sunt hus. Fuktdimensionering är en hjälp för att lyckas med detta. Fukt orsakar ofta dålig innemiljö och kostnaden för att åtgärda fuktskador uppgår till miljardbelopp årligen. Genom att använda den kunskap som finns skulle de vanligaste fuktproblemen kunna undvikas. Kunskapen finns dokumenterad bl a i serien Fuktsäkerhet i byggnade

Objectives. To investigate the total dispersion of ventricular repolarization of the epi- and endocardium. Design. Monophasic action potentials (MAP) were recorded from 211 +/- 54 (151-353) left and right ventricular epi- and endocardial sites during atrial pacing in 10 pigs using the CARTO system. The activation time (AT), MAP duration (MAPd) and end of repolarization time (EOR) were measured. Re

This thesis covers the development of a silicon neural interface, with focus on silicon sieve electrode fabrication, design, nerve regeneration, signal recording and biocompatibility. A study of how the via hole size and transparency of the perforated sieve membrane influences the nerve regeneration is presented together with a study on soft tissue responses to planar and porous silicon. A method