The risk for drug abuse, alcohol use disorder, and psychosocial dysfunction in offspring from high-density pedigrees : its moderation by personal, family, and community factors
Previous high-risk family designs in psychiatry have focused largely on offspring of affected parents. We take a pedigree-based approach and examine the social, psychological, and psychiatric features of offspring from extended pedigrees selected for high-densities of alcohol use disorder (AUD) or drug abuse (DA). We identified, from the Swedish population, 665,715 pedigrees containing a mean of 1