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The risk for drug abuse, alcohol use disorder, and psychosocial dysfunction in offspring from high-density pedigrees : its moderation by personal, family, and community factors

Previous high-risk family designs in psychiatry have focused largely on offspring of affected parents. We take a pedigree-based approach and examine the social, psychological, and psychiatric features of offspring from extended pedigrees selected for high-densities of alcohol use disorder (AUD) or drug abuse (DA). We identified, from the Swedish population, 665,715 pedigrees containing a mean of 1

In vitro evolution of antibodies inspired by in vivo evolution

In vitro generation of antibodies often requires variable domain sequence evolution to adapt the protein in terms of affinity, specificity, or developability. Such antibodies, including those that are of interest for clinical development, may have their origins in a diversity of immunoglobulin germline genes. Others and we have previously shown that antibodies of different origins tend to evolve a

Assertive discourse and folk linguistics : Serbian nationalist discourse about the cyrillic script in the 21st century

Ever since the wars of the Yugoslav secession in the nineties, linguistic nationalism has proven to have been among the more relevant instances in the discursive construction of national identity and new languages, dubbed by Ranko Bugarski as ‘administrative successors’ of Serbo-Croatian. Even though contemporary linguistics still classifies Serbo-Croatian as one language with regional varieties (

Normal vaginal delivery at term after expectant management of heterotopic caesarean scar pregnancy : A case report

Background: Heterotopic pregnancy with a combination of a caesarean scar pregnancy and an intrauterine pregnancy is rare and has potentially life-threatening complications. Case presentation: We describe the case of a 27-year-old white woman who had experienced an emergency caesarean delivery at 39 weeks for fetal distress with no postpartum complications. This is a report of the successful expect

Impact of Non-idealities on the Performance of InAs/(In)GaAsSb/GaSb Tunnel FETs

Measured InGaAsSb/InAs nanowire TFETs showing both, sub-60mV/dec slope and high ON-current, are simulated using calibrated TCAD. The focus is laid on the impact of non-idealities, such as hetero-interface traps, oxide-interface traps, and bulk traps on device characteristics. Simulated temperature-dependent transfer curves are in good agreement with the measured data which validates the simulation

Species diversity and abundance of dinoflagellate resting cysts seven months after a bloom of Alexandrium catenella in two contrasting coastal systems of the Chilean Inland Sea

In Chile, 90% of the fish farms and major natural shellfish beds are located in the region surrounding the Inland Sea, where over the last few decades harmful phytoplankton blooms have often been observed. The onset and recurrence of bloom events are often related to the resuspension and germination of resting cysts that have accumulated in the sediments. The degree of cyst settling, accumulation

Multi-period portfolio selection with drawdown control

In this article, model predictive control is used to dynamically optimize an investment portfolio and control drawdowns. The control is based on multi-period forecasts of the mean and covariance of financial returns from a multivariate hidden Markov model with time-varying parameters. There are computational advantages to using model predictive control when estimates of future returns are updated

Heparin-binding protein in sputum as a marker of pulmonary inflammation, lung function, and bacterial load in children with cystic fibrosis

Background: Cystic fibros.000000 bacterial pulmonary infections and neutrophil-dominated inflammation in the airways. The aim of this study was to evaluate the neutrophil-derived protein Heparin-binding protein (HBP) as a potential sputum marker of airway inflammation and bacterial load. Methods: Nineteen CF patients, aged 6-18 years, were prospectively followed for 6 months with sputum sampling a

Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ

Objectives: One mechanism by which cartilage responds to mechanical load is by releasing heparin-bound growth factors from the pericellular matrix (PCM). By proteomic analysis of the PCM, we identified connective tissue growth factor (CTGF) and here investigate its function and mechanism of action. Methods: Recombinant CTGF (rCTGF) was used to stimulate human chondrocytes for microarray analysis.

Acute leukemia cells resistant to PI3K/mTOR inhibition display upregulation of P2RY14 expression

The PI3K/mTOR pathway is the second most frequently deregulated pathway in a majority of cancers such as breast cancer, lung cancer, and melanomas as well as leukemia. Mutations in the genes coding for receptor tyrosine kinases (RTKs) and G-protein-coupled receptors (GPCRs) are quite common in all forms of acute leukemia. This can be a major cause of deregulation of the PI3K-mTOR pathway. To under

The Novel PrisMax Continuous Renal Replacement Therapy System in a Multinational, Multicentre Pilot Setting

Background/Aims: We assessed how the novel PrisMax continuous renal replacement therapy (CRRT) system performed in a prospective international multicentre setting. We compared this device to its predecessor, the Prismaflex, with regards to multiple treatment parameters. Additionally, we performed a survey, aiming to measure user satisfaction. Methods: Data was prospectively collected from 7 intens

Recent past (1979-2014) and future (2070-2099) isoprene fluxes over Europe simulated with the MEGAN-MOHYCAN model

Isoprene is a highly reactive volatile organic compound emitted by vegetation, known to be a precursor of secondary organic aerosols and to enhance tropospheric ozone formation under polluted conditions. Isoprene emissions respond strongly to changes in meteorological parameters such as temperature and solar radiation. In addition, the increasing CO2 concentration has a dual effect, as it causes b

Arginine "magic" : Guanidinium Like-Charge Ion Pairing from Aqueous Salts to Cell Penetrating Peptides

It is a textbook knowledge that charges of the same polarity repel each other. For two monovalent ions in the gas phase at a close contact this repulsive interaction amounts to hundreds of kilojoules per mole. In aqueous solutions, however, this Coulomb repulsion is strongly attenuated by a factor equal to the dielectric constant of the medium. The residual repulsion, which now amounts only to uni

The use of conservation tillage in an agro-intensive region : results from a survey of farmers in Scania, Sweden

Conventional agricultural practices can lead to soil erosion and a reduction in soil organic carbon (SOC) content. It has been suggested that less intensive agricultural practices, such as conservation tillage (including no-till and reduced till without soil inversion) may reduce both erosion and loss of SOC. The aim of this study was to determine whether, and why, conservation tillage is used in

Wilful Managerial Ignorance, Symbolic Work and Decoupling : A Socio-Phenomenological Study of ‘Managing Creativity’

Ignorance has only received scant attention in organization and management studies. This paper focuses on ignorance in an organizational context by presenting and analysing the lived experience of three managers who attempted to manage creativity. The analysis of the empirical material with the help of a detailed agency framework illustrates how the managers’ clearly articulated visions contradict

Biogeochemical interpretations of colored dissolved organic matter optical signatures (invited)

The optical properties of colored dissolved organic matter (CDOM) in surface waters are visible from space and observable throughout the water column in real time using in situ sensors. Due to their ease of measurement, CDOM optical properties are used as proxies for the quantity, quality and processing of dissolved organic matter (DOM) in natural waters. This talk will focus upon the use of these

Allochthony in major groups of crustacean zooplankton in boreal lakes – strongly contrasting patterns across space and time

The role of terrestrial organic carbon for recipient aquatic ecosystems is intensively researched. A multitude of studies now show that terrestrially-derived carbon supports a significant share (allochthony) of consumer biomass in many freshwaters. However, little is known about the mechanisms by which terrestrially-derived carbon is transferred to the level of metazoan zooplankton, and whether th