Healthy cortical bone tissue is both tough and strong and has a unique ability to resist fracture. One reason is the hierarchical structure of the tissue where toughening mechanisms at all length scales act to slow down or stop a propagating crack. The most potent toughening mechanisms arise at the microscale when cracks interact with the osteonal microstructure and deflect along weak interfaces.

PURPOSE: Advanced glycation end products (AGEs) can be formed in foods by the reaction of reducing sugars with proteins, and have been shown to induce insulin resistance and obesity in experimental studies. We examined the association between dietary AGEs intake and changes in body weight in adults over an average of 5 years of follow-up.METHODS: A total of 255,170 participants aged 25-70 years we

Inference of CO2 surface fluxes using atmospheric CO2 observations in atmospheric inversions depends critically on accurate representation of atmospheric transport. Here we characterize regional-scale CO2 transport uncertainties due to uncertainties in meteorological fields using a mesoscale atmospheric model and an ensemble of simulations with flow-dependent transport errors. During a 1-month sum

I det fjärde numret av Essä uppmärksammas ett helt vanligt grässtrå – fårsvingeln – genom Olof Rudbeck den äldres avbildning av det i det stora botaniska verket Campus Elysii som under dramatiska omständigheter nästan brann upp i stadsbranden i Uppsala 1702. De som tittat på gräset och skrivit om det är Erik Bergqvist, Gunnar Eriksson, Honor C. Prentice, Birgitta Lillpers, Carin Franzén och Jakob

Sustainability challenges are defined by their complex and multifaceted interactions between nature and society and contention as to how and where to direct problem-solving efforts. This chapter presents four different approaches that exist for framing sustainability challenge areas that are introduced and worked with by students in LUMES International Master Programme in Environmental Studies and

Background: Primary aldosteronism (PA) is the most common cause of secondary hypertension. Surgery is the mainstay of treatment for unilateral dominant PA, but reported cure rates varies. The aim of the present study was to investigate contemporary follow-up practices and cure rates after surgery for PA in Sweden. Methods: Patients operated for PA and registered in the Scandinavian Quality Registe

This study contributes to a growing stream of literature on servitization in management accounting. In extension to recent explorations in servitization and management accounting, this paper presents how KPIs in innovation reflect the shift towards servitization. The chosen methodology, participatory action design, gives a unique insight how organizations respond and construct KPIs (key performanc

that are influenced by use of management control systems (MCS). By means of a systematic literature review, the theoretical constructs are explored and related to part of the MCS, namely the performance measurement systems (PMS) and the business model of innovation (i.e. innovation input, process, output, and outcome). The results of the systematic literature review will be used to develop a set o

Background and purpose — Obesity defined as increased BMI is commonly associated with higher revision rates following total knee arthroplasty (TKA). We examined the effect of BMI on the rate of revision after TKA, for both infection and other reasons, and analyzed weight and height separately to provide better understanding of the risk profile. Patients and methods — The Swedish national knee arth

Failures in Alzheimer's disease (AD) drug trials highlight the need to further explore disease mechanisms and alterations of biomarkers during the development of AD. Using cross-sectional data from 377 participants in the BioFINDER study, we examined seven cerebrospinal fluid (CSF) and six plasma biomarkers in relation to β-amyloid (Aβ) PET uptake to understand their evolution during AD. In CSF, A

The oxygen reduction reaction (ORR) activity can strongly affect the performance of solid oxide fuel cells (SOFCs). To improve the electron transfer and enhance active sites for reactions in cathode, La0.8Sr0.2MnO3 mixed with Y2O3-stabilized ZrO2 (LSM/YSZ) nanofibers were co-fabricated by the electrospinning method. The fibers were well characterized and the electrochemical properties were evaluat

This thematic report addresses frameworks for innovation related public procurement. It focuses on four specific kinds of procurement, namely (1) direct innovation procurement, (2) catalytic innovation procurement, (3) functional regular procurement, and (4) Pre-Commercial Procurement (PCP). (1) – (3) are also called Innovation-Enhancing Procurement (IEP). The four different kinds of innovation re

New types of knowledge, and new ways of organising the production of it, may emerge as knowledge producers respond to the challenges posed by a changing society. This paper focuses on the core knowledge of one such emerging field, namely, innovation studies. To explore the knowledge base of the field, a database of references in scholarly surveys of various aspects of innovation, published in "han

Insulin and C-peptide responses to 0.5 g kg-1 intravenous glucose and 1.0 mg glucagon were studied in 34 healthy subjects (age 19-78 years, mean 45). Fasting blood glucose (r=0.59; p