Search results
Filter
Filetype
Your search for "*" yielded 530849 hits
A Retrospective Evaluation of the Predictive Value of Newborn Screening for Vitamin B12 Deficiency in Symptomatic Infants Below 1 Year of Age
Background: The sensitivity of newborn screening (NBS) in detecting infants that later develop symptomatic vitamin B12 deficiency is unknown. We evaluated the predictive value using NBS algorithms in detecting infants that later were clinically diagnosed with symptomatic B12 deficiency. Furthermore, we investigated whether being born in a hospital using nitrous oxide (N2O) as pain relief in labor
The MEK Inhibitor Trametinib Improves Outcomes following Subarachnoid Haemorrhage in Female Rats
Aneurysmal subarachnoid haemorrhage (SAH) is a haemorrhagic stroke that causes approximately 5% of all stroke incidents. We have been working on a treatment strategy that targets changes in cerebrovascular contractile receptors, by blocking the MEK/ERK1/2 signalling pathway. Recently, a positive effect of trametinib was found in male rats, but investigations of both sexes in pre-clinical studies a
Impact of Methane and Hydrogen-Enriched Methane Pilot Injection on the Surface Temperature of a Scaled-Down Burner Nozzle Measured Using Phosphor Thermometry
The surface temperature of a burner nozzle using three different pilot hardware configurations was measured using lifetime phosphor thermometry with the ZnS:Ag phosphor in a gas turbine model combustor designed to mimic the Siemens DLE (Dry Low Emission) burner. The three pilot hardware configurations included a non-premixed pilot injection setup and two partially premixed pilot injections where o
Conspiratorial Attitude of the General Public in Jordan towards Emerging Virus Infections : A Cross-Sectional Study Amid the 2022 Monkeypox Outbreak
Conspiracy theories accompany the emergence of infectious diseases and the 2022 multi-country monkeypox (MPX) outbreak is no exception. It is possible that the adoption of conspiracy beliefs negatively impacts health behavior. We aimed to assess the prevalence of conspiratorial attitudes towards emerging virus infections (EVIs) and the response measures aiming to control these infections among the
The Risk of Pyelonephritis Following Uncomplicated Cystitis : A Nationwide Primary Healthcare Study
Background: The risk of pyelonephritis following uncomplicated lower urinary tract infection (cystitis) in women has not been studied in well-powered samples. This is likely due to the previous lack of nationwide primary healthcare data. We aimed to examine the risks of pyelonephritis following cystitis in women and explore if antibiotic treatment, cervical cancer, parity, and sociodemographic fac
Cross-Feeding and Enzymatic Catabolism for Mannan-Oligosaccharide Utilization by the Butyrate-Producing Gut Bacterium Roseburia hominis A2-183
β-Mannan is abundant in the human diet and in hemicellulose derived from softwood. Linear or galactose-substituted β-mannan-oligosaccharides (MOS/GMOSs) derived from β-mannan are considered emerging prebiotics that could stimulate health-associated gut microbiota. However, the underlying mechanisms are not yet resolved. Therefore, this study investigated the cross-feeding and metabolic interaction
Glueball Dark Matter Revisited
We revisit the possibility that dark matter is composed of stable scalar glueballs of a confining dark SU(3) gauge theory coupled only to gravity. The relic abundance of dark glueballs is studied for the first time in a thermal effective theory accounting for strong-coupling dynamics. An important ingredient of our analysis is the use of an effective potential for glueballs that is fitted by latti
14-3-3 Activated Bacterial Exotoxins AexT and ExoT Share Actin and the SH2 Domains of CRK Proteins as Targets for ADP-Ribosylation
Bacterial exotoxins with ADP-ribosyltransferase activity can be divided into distinct clades based on their domain organization. Exotoxins from several clades are known to modify actin at Arg177; but of the 14-3-3 dependent exotoxins only Aeromonas salmonicida exoenzyme T (AexT) has been reported to ADP-ribosylate actin. Given the extensive similarity among the 14-3-3 dependent exotoxins, we initi
An Investigation of the Relationship between Personality, Cognitive Ability, and Work Engagement in Intellectually Gifted Individuals
Do personality traits in highly intelligent individuals relate to their work engagement? Seemingly little is known about the relationship between personality and work engagement for gifted individuals. In what may be the first study to do so, a Swedish Mensa sample (n = 353) was explored with a two-part aim: to assess psychometric personality properties and to investigate the relationship between
Husserl and Heidegger on Modernity and the Perils of Sign Use
In his late writings Husserl emphasizes how the semiotic properties of writing, and of mathematical formulae and diagrams, are crucial for the historical, cross-generational survivability of meaning and specifically indispensable to the operation of scientific knowledge. However, the demand for objectivity, exactitude, and repeatability insidiously interferes with the meaning that such signs seek
Enforcing and Resisting Hindutva : Popular Culture, the COVID-19 Crisis and Fantasy Narratives of Motherhood and Pseudoscience in India
This article analyzes how Hindu nationalists employ fantasy narratives to counteract resistance, with a particular focus on narratives of ‘motherhood’ and ‘pseudoscience’. It does so by first introducing a conceptual discussion of the relationship between fantasy narratives, ontological insecurity, gender, and anti-science as a more general interrelationship characterizing pre- and post-COVID-19 f
Combining pharmacophore models derived from DNA-encoded chemical libraries with structure-based exploration to predict Tankyrase 1 inhibitors
DNA-encoded chemical libraries (DECLs) interrogate the interactions of a target of interest with vast numbers of molecules. DECLs hence provide abundant information about the chemical ligand space for therapeutic targets, and there is considerable interest in methods for exploiting DECL screening data to predict novel ligands. Here we introduce one such approach and demonstrate its feasibility
Organotypic Cultures of Adult Human Cortex as an Ex vivo Model for Human Stem Cell Transplantation and Validation
Neurodegenerative disorders are common and heterogeneous in terms of their symptoms and cellular affectation, making their study complicated due to the lack of proper animal models that fully mimic human diseases and the poor availability of post-mortem human brain tissue. Adult human nervous tissue culture offers the possibility to study different aspects of neurological disorders. Molecular, cel
Analysis of liquid surface deformation and breakups using three-dimensional high-speed data recorded with a single camera
Analyzing the deformation of liquid surfaces to better understand, for example, wave generation in oceanology or the formation of industrial spray systems, requires a series of three-dimensional snapshots that temporally resolve such events. This requirement is challenging, especially when applied to transient liquid surfaces that deform rapidly. A technique called Fringe Projection-Laser Induced
Analysing the Economic Viability of Implicit Demand Response Control of Thermal Energy Storage in Hot Water Tanks
Demand-responsive control of electrically heated hot water storage tanks (HWSTs) is one solution, already present in the building stock, to stabilise volatile energy networks and markets. This has been put into sharp focus with the current energy crisis in Europe due to reduced access to natural gas. Furthermore, increasing proportions of intermittent renewable energy will likely add to this volat
Urban Sustainability : Recovering and Utilizing Urban Excess Heat
Urban heat sources from urban infrastructure and buildings could meet ~10% of the European building heating demand. There is, however, limited information on how to use them. The EU project ReUseHeat has generated much of the existing knowledge on urban waste heat recovery implementation. Heat recovery from a data center, hospital and from water were demonstrated. Additionally, the project generat
Research gaps and opportunities in precision nutrition : an NIH workshop report
Precision nutrition is an emerging concept that aims to develop nutrition recommendations tailored to different people's circumstances and biological characteristics. Responses to dietary change and the resulting health outcomes from consuming different diets may vary significantly between people based on interactions between their genetic backgrounds, physiology, microbiome, underlying health sta
The food courier, the mobile phone and the power geometry of mobility
Clinical characteristics and mortality of patients with heart failure in Southern Sweden from 2013 to 2019 : a population-based cohort study
OBJECTIVES: To describe clinical characteristics and prognosis related to heart failure (HF) phenotypes in a community-based population by applying a novel algorithm to obtain ejection fractions (EF) from electronic medical records. DESIGN: Retrospective population-based cohort study. SETTING: Data were collected for all patients with HF in Southwest Sweden. The region consists of three acute care