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G protein-coupled estrogen receptor 1 (GPER) in the female reproductive tract: from physiology to cancer
Popular Abstract in Swedish Östrogen är ett av de viktigaste/ mest studerade kvinnliga könshormonerna som styr utvecklingen av våra fortplantningsorgan och deras reproduktionsförmåga. Östrogen påverkar dessutom många av kroppens andra organ, bland annat hjärnan, skelettet, och hjärt-kärlsystemet. Mängden östrogen som finns i kroppen varierar vanligtvis under menstruationscykeln och med kvinnans ålEstrogen effects are mediated either through genomic action involving the classical estrogen receptors, estrogen receptor alpha (ERα) and beta (ERß), which function as transcription factors in the nucleus, or through rapid non-genomic action via receptors associated with plasma membrane. Recently, a member of the G protein-coupled receptor family was ascribed estrogen receptor properties and propo
A Pilgrimage to the Past : Johannes Bureus and the Rise of Swedish Antiquarian Scholarship, 1600-1650
At the end of the eighteenth century, Edward Gibbon described the antiquarian scholars of previous generations as men of “profound learning and easy faith.” His exemplar was the Swedish polymath Olof Rudbeck, who in a series of frantic and combative tomes sought to portray Sweden as the model for Plato’s Atlantis and the seething cultural cauldron from which Western civilization had emerged. A Pil
A new formulation of the water wave problem for Stokes waves of constant vorticity
We consider steady symmetric gravity water waves on finite depth with constant vorticity and a monotone surface profile between crests and troughs. The problem is transformed into one concerning the vertical velocity. A representation formula for the stream function in terms of the surface and the vorticity is presented, and we show that the surface can be determined from the vertical velocity.
Diagnosis-prescribing surveys in 2000, 2002 and 2005 in Swedish general practice: Consultations, diagnosis, diagnostics and treatment choices
The aim of this study is to present diagnostic patterns, diagnostics used and antibiotic treatment in relation to guidelines in 3 repeated diagnosis-prescription studies conducted simultaneously in general practice in 5 Swedish counties, during 1 week in November 2000, 2002 and 2005. General practitioners (GPs) at the participating health centres were asked to complete a form for all patients with
Hydrogen analysis and profiling with a position sensitive detector
The double sided silicon strip detector (DSSSD) is a segmented silicon detector commonly used in the fields of high energy physics and nuclear physics. This type of detector is used for analysis of reactions produced by charged particles. This makes it well suited for a number of analytical methods commonly used in ion beam analysis (IBA), such as Rutherford Backscattering (RBS) and elastic recoil
The Swedish Knee Arthroplasty Register ( www.knee.se ).
Mitochondrial function in sepsis - Temporal evolvement of respiratory capacity in human blood cells
Popular Abstract in Swedish Allt liv på jorden är beroende av energi. Växter och vissa bakterier kan fånga och utnyttja solens energi för att bygga upp sina celler och dess delkomponenter som fetter, sockerarter och proteiner. Den energi som på så sätt blir bunden i dessa molekyler kan användas av djur och människor genom att vi konsumerar dem. För att energin skall kunna utnyttjas av kroppen måstSepsis is a devastating disease that is caused by the host’s response to an overwhelming infectious process. As sepsis progresses, organs distant from the site of infection become affected and sepsis-induced multiple organ failure ensues. An impaired immunologic response, including dysfunctional peripheral blood immune cells has been described as part of the septic syndrome. Mitochondrial dysfunct
Cell-line-specific stimulation of tumor cell aggressiveness by wound healing factors - a central role for STAT3
Background: Local recurrence is a major factor affecting survival after treatment for head and neck squamous cell carcinoma (HNSCC). It is possible that the normal processes involved in wound healing after surgical removal of a primary tumor can boost the regrowth of residual cancer cells, thereby contributing to the recurrent growth. In this work, we collected human wound fluids and used them to
Living Law and Political Stability in Post-Soviet Central Asia : A Case Study of the Ferghana Valley in Uzbekistan
Central Asian countries are facing multidimensional political stability and security challenges in the post-Soviet period. Current scholarly discussions of political stability in post-Soviet Central Asia continue to revolve around the issues of Islamic upheaval, ethnic conflicts, civil war or inter-clan struggles, and how the authoritarian regimes in this region deploy coercive strategies and pena
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This thesis explores different aspects of the syntax and discoursepragmatics of predicative anaphors(i.e. proforms and ellipsis)in German and Swedish. The types of anaphoric constructions considered in the analysis are: (i) overt predicative proform expressions, instantiated by the neuter proform "es"/"das" in German and "det" in Swedish, and (ii) covert elliptical instantiations, reminiscent of t
Spasticity of the gastrosoleus muscle is related to the development of reduced passive dorsiflexion of the ankle in children with cerebral palsy A registry analysis of 2,796 examinations in 355 children
Background and purpose Spasticity and muscle contracture are two common manifestations of cerebral palsy (CP). A spastic muscle may inhibit growth in length of the muscle, but the importance of this relationship is not known. In 1994, a register and a healthcare program for children with CP in southern Sweden were initiated. The child's muscle tone according to the Ashworth scale and the ankle ran
Multimodal constructions in children : is the headshake part of language?
Swedish children’s use of the headshake from 18 to 30 months shows a developmental progression from rote-learned coordination with speech to increasingly more flexible and productive coordination with speech. To deal with these observations, I introduce the concept of multimodal constructions in order to extend usage-based approaches to language learning and construction grammar into the kinetic d
Nuclear Structure Addressed At GSI/RISING
Nuclear structure spectroscopy studies at GSI recently gained increased momentum within a broad international community with the installation of the Rare Isotopes Spectroscopic INvestigation at GSI (RISING) project. A wide range of physical phenomena has been addressed by high-resolution in-beam gamma-ray spectroscopy experiments with radioactive beams. Relativistic radioactive beams are implanted
Luscus: molecular viewer and editor for MOLCAS.
The novel program for graphical display and editing of molecular systems, luscus, is described. The program allows fast and easy building and/or editing different molecular structures, up to several thousands of atoms large. Luscus is able to visualise dipole moments, normal modes, molecular orbitals, electron densities and electrostatic potentials. In addition, simple geometrical objects can be r
Variability of clinical manifestations of factor VII-deficiency in subjects homozygous or heterozygous for the F7 gene mutation A294V
Advanced clinical MRI for better outcome in epilepsy surgery. Focusing on fMRI and prediction of verbal memory decline.
Abstract Aim: The aim of the thesis was to evaluate the use of advanced MRI technology to improve results of epilepsy surgery, with focus on language and memory functions. Methods: In paper I, 25 patients with drug-resistant epilepsy were retrospectively included in the study for having been referred to high resolution 3T MRI with and without surface coils. The surface coils were placed over the s
Från romartida skalpeller till senvikingatida urnesspännen : nya materialstudier från Uppåkra
Testing the quality of carriers: a field experiment on lizard signallers
In the Australian painted dragon lizard (Ctenophorus pictus), males occur in two different morphs with respect to gular color, with or without a yellow bib. Males without a bib lost within-clutch paternity significantly more often to rivals than bibbed males. Thus, it appears that bibs identify some phenotypic advantage linked to competitive ability. To test whether this could be related to whole-