Purpose: Validation of artificial intelligence (AI) algorithms in digital pathology with a reference standard is necessary before widespread clinical use, but few examples focus on creating a reference standard based on pathologist annotations. This work assesses the results of a pilot study that collects density estimates of stromal tumor-infiltrating lymphocytes (sTILs) in breast cancer biopsy s

Follow-up survey on legal status of information society service providers in the post-CDSM Directive era in Sweden, focusing on service providers as intermediaries and as users of copyright-protected content (March 2022). Phase 2 report, part of ReCreating Europe project WP6 - Intermediaries.

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Our global sustainability challenges are complex and require partnerships and collaboration across disciplines and sectors. As such, as a society, we must value interdisciplinary perspectives and work together to address these challenges. In this episode, we discuss the value of interdisciplinary education to address our complex sustainability challenges. We share the experience from our two inter

Background: The combination of diphenylcyclopropenone (DCP) and anthralin may demonstrate synergistic effects in the treatment of chronic extensive alopecia areata (AA).Objective: The objective of the study was to compare the efficacy of the combination therapy of topical DCP and topical 0.5% anthralin versus topical DCP alone for the treatment of chronic extensive AA.Materials and Methods: Ten pa

Grout based on microfine cement is mainly used for sealing of rock fractures in underground construction with high sealing requirements. This grout is known as hard dispersed, compared to grouts based on ordinary Portland cement. This study investigates the possibility of using ultrasound to improve the dispersion of microfine cement grout. Ultrasound dispersion is compared with dispersion efficie

A unique exposure of a strongly deformed late Mesoproterozoic augen-granite (U–Pb zircon age 1146 ± 4 Ma) was detected within rocks on the eastern rim of the West African Craton. These rocks, together with their sedimentary cover, were reworked during the Neoproterozoic Pan-African Dahomeyan orogeny, and are now incorporated in the Dahomeyan orogenic belt of southeast Ghana. To the authors’ knowle

The human antimicrobial peptide LL-37 is produced by neutrophils and epithelial cells, and the peptide can be detected in plasma as well as saliva. LL-37 is active against both gram-positive and gram-negative bacteria including oral pathogens such as Porphyromonas gingivalis and Streptococcus mutans. Besides its antimicrobial properties, LL-37 modulates the innate immune system, and furthermore, i

Objective: The incidence of urinary stones is increasing across the globe. Surgical treatment includes extracorporal shock-wave lithotripsy (ESWL), ureterolithotripsy (URS), percutaneous nephrolitotomy (PCNL) and rarely open surgery. This single center study describes complications to PCNL focusing on infections, bacterial growth/resistance and antibiotic prophylaxis/treatment. Materials and metho

Background: Retrospective studies on MRI-only radiotherapy have been presented. Widespread clinical implementations of MRI-only workflows are however limited by the absence of guidelines. The MR-PROTECT trial presents an MRI-only radiotherapy workflow for prostate cancer using a new single sequence strategy. The workflow incorporated the commercial synthetic CT (sCT) generation software MriPlanner

The STRIPAK complex has been linked to a variety of biological processes taking place during embryogenesis and development, but its role in cancer has only just started to be defined. Here, we expand on previous work indicating a role for the scaffolding protein STRIP1 in cancer cell migration and metastasis. We show that cell cycle arrest and decreased proliferation are seen upon loss of STRIP1 i

Fear has been assigned a central role in models of obsessive–compulsive disorder (OCD), but empirical investigations into the emotions that underpin OCD symptoms are few, especially in pediatric samples. Using validated, clinician-led structured interviews, 124 youth with OCD reported on the presence and severity of symptoms across the main symptom dimensions of OCD (aggressive, symmetry, contamin

Ocean Drilling Program (ODP) Site 1051 (Blake Nose, western North Atlantic) is of crucial importance for reconstructing diatom evolution and biosiliceous sedimentation patterns through the early Cenozoic period of extreme greenhouse warmth followed by the progressive global cooling. The magnetostratigraphy in Hole 1051A, however, has been subject to divergent interpretations resulting in multi-mil

Health anxiety can be defined as a multifaceted trait that is primarily characterised by a fear of, or preoccupation with, serious illness. Whereas low levels of health anxiety can be helpful, clinically significant levels are associated with personal suffering and substantial societal costs. As general anxiety is probably on the rise, and the Internet has increased access to health-related inform

Large carnivores elicit strong emotional reactions, which could influence consensus or social conflicts between persons promoting wildlife conservation and people who suffer from its negative consequences. Interventions to prevent carnivore attacks on domestic animals are intended to promote coexistence between people and carnivores, but could fail to mitigate fear and social conflicts if emotions

The intestine contains some of the most diverse and complex immune compartments in the body. Here we describe a method for isolating human gut-associated lymphoid tissues (GALTs) that allows unprecedented profiling of the adaptive immune system in submucosal and mucosal isolated lymphoid follicles (SM-ILFs and M-ILFs, respectively) as well as in GALT-free intestinal lamina propria (LP). SM-ILF and

Intersectional studies are expanding and generating vital and much-needed theoretical debate in the discipline of feminist/gender studies. The aim of this article is to contribute to the debate through a critical reflection over the process of translation through which the concept has been introduced, interpreted and acted upon in Swedish gender studies. The purpose is also to bridge the concept o