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Malignant melanoma is a very aggressive skin cancer, characterized by a heterogeneous nature and high metastatic potential. The incidence of melanoma is continuously increasing worldwide, and it is one of the most common cancers in young adults. In the past twenty years, our understanding of melanoma biology has increased profoundly, and disease management for patients with disseminated disease ha

Purpose: Paleolithic Diet Fraction (PDF) estimates how large a portion of the absolute dietary intake stems from food groups included in the Paleolithic diet. In randomized controlled trials higher PDFs have been associated with healthier levels of cardiometabolic risk markers. Our aim was to build upon these findings by examining associations between PDF and mortality and incidence of cardiometab

Objective: Mitral valve reconstruction in the pediatric population is a challenge due to the frequent combination of annular dilatation and leaflet restriction and the need for growth. We present a novel strategy using leaflet expansion and subpartial annuloplasty with polytetrafluoroethylene reinforcement. Methods: From January 2014 through May 2021, 11 children aged 5 months to 14 years (median,

The purpose of this study was to describe experiences of pain among students at upper secondary schools (adolescents aged 16–19 years) in Sweden. Focus group (n = 9) interviews with 41 adolescents were conducted in southern Sweden in 2021. The interviews were analyzed by qualitative content analysis, which identified four categories encompassing the theme how pain expressed itself: (1) a warning b

Proximity testing is at the core of several Location-Based Services (LBS). Despite a series of reported and confirmed abuses, modern LBSs still demand their clients to disclose their locations in plain in order to preform location proximity testing. This works aims at enhancing proximity testing with privacy. We design CatNap a novel protocol that (1) implements precise Euclidean distance matching

Seismic Structural Health Monitoring (S2HM) provides information about the integrity of civil structures and infrastructure in the aftermath of an earthquake. However, quantifying the benefits of S2HM information is crucial to justify the investment in S2HM systems. The benefit of S2HM can be computed through the Value of Information (VoI) from Bayesian decision theory, which compares the expected

In this study, we explore the constitution of user representations of robots in design practice. Using the results of ethnographic research in two robot laboratories, we show how user representations emerge in and are entangled with design activities. Our study speaks to the growing popularity of and investment in robotics, robots and other forms of artificial intelligence. Scholars in Science and

Stratigraphic sites in north-west Svalbard record at least six significant glacial advances in the last 200 Ky, and sediments deposited under locally high relative sea level during intervening interstadials or interglacials contain abundant benthic foraminifera. We present a biostratigraphic record from the Kongsfjordhallet site in the Kongsfjorden area that covers five high relative sea-level eve

Background: Growing evidence suggests intergenerational effects of paternal pre-conceptional smoking through the germ line, but its specific impact on offspring semen quality remains uncertain because of challenges in isolating paternal exposure from maternal passive smoking or underreporting. Methods: We reran previous analyses estimating differences in semen parameters and testicular size accord

Background: The aim was to investigate to what extent the quantification of myocardial blood flow (MBF) from dynamic 13N-NH3 positron emission tomography (PET) images is affected by time frame schemes, time-of-flight (ToF), reconstruction algorithms, blood pool volume of interest (VOI) locations and compartment models in patients with suspected chronic coronary syndrome. Methods: A standard MBF va