Bakgrund: Risken för att få en främre korsbandsskada (ACL-skada) eller ligamentskada i knät som kvinna är 2-3 gånger större än för en man. Det finns flera olika teorier kring varför betydligt fler kvinnor drabbas av skada, däribland anatomiska skillnader och strukturella, biomekaniska, neuromuskulära och hormonella faktorer. Fler forskare har på senare tid undersökt om det finns ett samband mella

Due to a combination of changes in the societal view on fire safety along with reconstruction and renovations, the fire rescue services are no longer able to act as an alternative escape route from some buildings in urban parts of large cities. This thesis aims to survey how widespread the problem is, as well as identify and evaluate different solutions. Surveys and interviews were conducted to ev

Bakgrund Ländryggssmärta har i tidigare forskning visat sig vara ett återkommande problem hos studenter på olika vårdvetenskapliga program. Under covid-19 pandemin ökade stillasittandet till följd av distansundervisning och isolering, vilket för många innebar att smärtan förvärrades. Pandemin orsakade även en högre upplevd stressnivå för studenter samt att man i en kortare utsträckning uppnådde re

Over recent years, there has been a rapid development of membrane-mimetic systems to encapsulate and stabilize planar segments of phospholipid bilayers in solution. One such system has been the use of amphipathic copolymers to solubilize lipid bilayers into nanodiscs. The attractiveness of this system, in part, stems from the capability of these polymers to solubilize membrane proteins directly fr

This chapter reviews the evolving understanding of structuring in deep eutectic solvents (DESs) with a focus on choline chloride-based systems as the most popularly studied DES. Recent literature is critically evaluated to attempt to identify common aspects of the structure and interactions in different DESs to improve our fundamental understanding of these solvents.

Wide-angle neutron scattering experiments combined with Empirical Potential Structural Refinement modelling have been used to study the detailed structure of decyltrimethylammonium bromide (C10TAB) micelles at two different temperatures; 25°C and 50°C and two concentrations; 0.4 and 0.8 M in water. At higher temperature, the micelles become smaller, and fewer counterions bind to the micelle surfac

The interfacial nanostructure of the three most widely-studied Deep Eutectic Solvents (DESs), choline chloride:urea (ChCl:Urea), choline chloride:ethylene glycol (ChCl:EG), and choline chloride:glycerol (ChCl:Gly) at a Pt(111) electrode has been studied as a function of applied potential and water content up to 50 wt%. Contact mode atomic force microscope (AFM) force-distance curves reveal that fo

Bakgrund Handboll innehåller mycket kroppskontakt och riktningsförändringar i hög hastighet och med stora krafter. Baserat på sportens utformning är axelskador vanligt förekommande, både i form av akuta skador till följd av att spelare blir dragna i armen eller landar på armen, och överbelastningsskador från upprepade skott och passningar. Syftet med studien var att kartlägga och jämföra förekomst

Endosomal entrapment is a key issue for the intracellular delivery of many nano-sized biotherapeutics to their cytosolic or nuclear targets. Photochemical internalisation (PCI) is a novel light-based solution that can be used to trigger the endosomal escape of a range of bioactive agents into the cytosol leading to improved efficacy in pre-clinical and clinical studies. PCI typically depends upon

Zwitterionic cellulose nanofibrils (ZCNFs) with an isoelectric point of 3.4 were obtained by grafting glycidyltrimethylammonium chloride onto TEMPO/NaBr/NaOCl-oxidised cellulose nanofibrils. The ZCNF aqueous dispersions were characterized via transmission electron microscopy, rheology and small angle neutron scattering, revealing a fibril-bundle structure with pronounced aggregation at pH 7. Surfa

Background: Small-angle scattering (SAS) is a powerful technique capable of determining the sample averaged structure of systems within sizes ranging from 1 nm to ~500 nm. This is particularly useful when applied to the study of self-assembled organic systems. Objective: This review article introduces the method of model-dependent analysis of small angle scattering. Method: The underlying mathemat

Wide-angle neutron scattering experiments combined with empirical potential structural refinement modeling have been used to study the detailed structure of decyltrimethylammonium bromide micelles in the presence of acid solutions of HCl or HBr. These experiments demonstrate considerable variation in micelle structure and water structuring between micelles in the two acid solutions and in comparis

Biological substances based on proteins, including vaccines, antibodies, and enzymes, typically degrade at room temperature over time due to denaturation, as proteins unfold with loss of secondary and tertiary structure. Their storage and distribution therefore relies on a “cold chain” of continuous refrigeration; this is costly and not always effective, as any break in the chain leads to rapid lo

The nanostructure of a series of choline chloride/urea/water deep eutectic solvent mixtures was characterized across a wide hydration range by neutron total scattering and empirical potential structure refinement (EPSR). As the structure is significantly altered, even at low hydration levels, reporting the DES water content is important. However, the DES nanostructure is retained to a remarkably h

A large proportion of grafted striatal neurons die, and mechanisms by which they succumb may involve excitotoxicity and oxidative stress. We investigated the effects of pretreatment of the graft tissue with the N-methyl-D-aspartate (NMDA) receptor antagonist (+)dizocilpine hydrogen maleate (MK-801) and lipid peroxidation inhibitor lazaroid U-83836E on the survival of transplanted striatal neurons.

PURPOSE Heart failure (HF) is a potentially life-threatening complication of treatment for childhood cancer. We evaluated the risk and risk factors for HF in a large European study of long-term survivors. Little is known of the effects of low doses of treatment, which is needed to improve current treatment protocols and surveillance guidelines.METHODSThis study includes the PanCareSurFup and ProCa