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Conventional vaginal approach vs. transvaginal natural orifice transluminal endoscopic surgery for treating apical prolapse, a randomized controlled study

Objective: Vaginal hysterectomy combined with uterosacral suspension (USLS) is a technique for treating pelvic organ prolapse. Vaginal natural orifice transluminal endoscopic surgery (vNOTES) has been described as an alternative minimal invasive approachfor treating various gynecological and non-gynecological pathologies. The aim was to compare the surgical time between conventional vaginal hyster

Eutrophication promotes resource use efficiency and toxin production of Microcystis in a future climate warming scenario

Addressing the risks of cyanobacterial blooms and toxin production under ongoing and accelerating eutrophication and climate warming is crucial for both water ecosystem services and human health. Therefore, we here explored the interactive effects of eutrophication and warming on freshwater ecosystems, focusing on Microcystis and its cyanotoxin production. We employed a large-scale mesocosm system

Kidney function, uric acid, and risk of atrial fibrillation : experience from the AMORIS cohort

Background: Uric acid closely relates to both kidney disease and atrial fibrillation (AF), yet the extent to which it influences the kidney-AF association remains uncertain. We examined the relationship between kidney function and risk of AF, accounting for uric acid levels. Methods: A total of 308,509 individuals in the Swedish Apolipoprotein-Related Mortality Risk (AMORIS) cohort were included a

Long-term outcome of kidney function in patients with ANCA-associated vasculitis

Background. Kidney involvement is common in anti-neutrophil cytoplasm antibody-associated vasculitis (AAV) and the prognosis is determined by the severity of kidney damage. This study focused on long-term kidney outcomes, defining possible risk factors and comparing the performance of three different histological classifications to predict outcomes for patients with AAV. Methods. The dataset inclu

Defective ribosome assembly impairs leukemia progression in a murine model of acute myeloid leukemia

Despite an advanced understanding of disease mechanisms, the current therapeutic regimen fails to cure most patients with acute myeloid leukemia (AML). In the present study, we address the role of ribosome assembly in leukemia cell function. We apply patient datasets and murine models to demonstrate that immature leukemia cells in mixed-lineage leukemia-rearranged AML are characterized by relative

Physiotherapy students’ academic performance and satisfaction after following a chest physiotherapy course in hybrid mode : a case-control study

Hybrid e-learning offered flexibility for students who could not attend in-person classes during the COVID-19 pandemic, but its effectiveness in teaching chest physiotherapy remains to be determined. This retrospective case-control study assessed physiotherapy students’ academic performance and satisfaction with a hybrid classroom approach adopted during the COVID-19 pandemic for teaching airway c

An introduction to recent approaches underlying mechanistic insights harboring oncobiology

The field of oncobiology is witnessing rapid progress, with numerous ongoing studies dedicated to comprehending the intricate mechanisms underlying cancer initiation, progression, and therapeutic interventions. Despite significant strides, there remains a substantial gap in fully understanding the multifaceted factors driving cancer development and trajectory. This chapter delves into the imperati

Development and application of a hybrid artificial neural network model for simulating future stream flows in catchments with limited in situ observed data

The need to develop new and computationally efficient artificial intelligence models that accurately simulate river flows in data-scarce regions, considering not only current but also projected future climate change conditions is vital. In this study, a hybrid artificial neural network (ANN) model that combines HEC-HMS and the feed-forward neural network (FFNN) was developed in the Python programm

Targeted metagenomics – Enrichment for enzymes active on sulfated polysaccharides from seaweeds

Seaweeds (macroalgae) are an attractive resource for diverse microbial- and enzymatic production processes. They are abundant, underutilized, cheap, and rich in carbohydrates, and therefore have the potential to be used as a source of mono- or oligosaccharides, and as substrates for industrial fermentation processes. Many seaweed polysaccharides, including the sulfated polysaccharides ulvan and fu

Walking by design : how to build artificial molecular motors made of proteins

To design an artificial protein-based molecular motor that can autonomously step along a track is a key challenge of protein design and synthetic biology. We lay out a roadmap for how to achieve this aim, based on a modular approach that combines the use of natural, non-motor proteins with de novo design. We define what can be considered to constitute a successful artificial protein motor, identif

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On May 26, 2021, the European Medical Device Regulation (EU-MDR) entered into effect resulting in a major shift in the requirements for assessment of medical devices in Europe. The EU-MDR Cardiovascular Collaboratory (EU-MCVC) was founded to contribute to the development of faster, more efficient, and more effective pathways for innovation of cardiac medical devices. A registry is an organized sys

Algae potential resource assessment for the energy and chemistry sectors in France by 2030

To address environmental and climate issues, alternative technologies to fossil resources are sought after, both for the production of fuels and of chemicals. Algae appear as an attractive solution and have applications in the food, feed, energy or chemistry at large. A study funded by ADEME and conducted by ENEA, a consulting firm for energy and sustainable development for the industrial sector,

Assessing grain boundary variability through phase field crystal simulations

Characterization of grain boundaries (GBs) typically focuses exclusively on ideal minimum-energy structures,thus offering a limited perspective on the potential structural diversity and related property variations of GBs.In this study, phase field crystal (PFC) simulations are employed to systematically explore alternative GBstates through γ -surface sampling. A large number of tilt and twist GBs

3D distribution of biomineral and chitin matrix in the stomatopod dactyl club by high energy XRD-CT

Stomatopods are ferocious hunters that use weaponized appendages to strike down their pray. The clubs of species such as Odontodactylus scyllarus undergo tremendous forces, and in consequence they have intricate structures, consisting of hydroxyapatite, chitin, amorphous calcium phosphate and carbonate, and occasionally calcite. These materials are distributed differently across the four major zon

A 1D imaging soft X-ray spectrometer for the small quantum systems instrument at the European XFEL

A 1D imaging soft X-ray spectrometer installed on the small quantum systems (SQS) scientific instrument of the European XFEL is described. It uses movable cylindrical constant-line-spacing gratings in the Rowland configuration for energy dispersion in the vertical plane, and Wolter optics for simultaneous 1D imaging of the source in the horizontal plane. The soft X-ray fluorescence spectro-imaging

An overview of the ESS cryogenic system and its design evolution

Superconductivity and cryogenics were recognized as necessary to the European Spallation Source (ESS) project from its earliest days. This chapter provides a highlevel overview of the ESS cryogenics system and describes the reasoning behind early conceptual design choices. Some requirements for the cryogenic system did change over time and that evolution is discussed. In addition, the recruitment

The Gut Microbiota and Diabetes : Research, Translation, and Clinical Applications—2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum

This article summarizes the state of the science on the role of the gut microbiota (GM) in diabetes from a recent international expert forum organized by Diabetes, Diabetes Care, and Diabetologia, which was held at the European Association for the Study of Diabetes 2023 Annual Meeting in Hamburg, Germany. Forum participants included clinicians and basic scientists who are leading investigators in

Perturbation theory for embedded eigenvalues of asymptotically periodic operators

This thesis explores the persistence of embedded eigenvalues of asymptotically periodic Schrödinger-type operators under perturbations on domains with only one unbounded direction. Embedded eigenvalues present unique challenges, as they lie within the continuous spectrum, making their stability under perturbations a nontrivial problem.The aim of the first part of the thesis is to provide a general