Background: In microscopic colitis (MC), the incidence has increased over the last decades. The aim of the present study was to determine the incidence of lymphocytic (LC) and collagenous colitis (CC) in the county Skåne (Scania), southern Sweden, during the period 2010–20 with focus both on the temporal and spatial variations. Methods: The MC diagnosis was retrieved from the biopsy registries at

Background Randomized trials of venetoclax plus anti-CD20 antibodies as first-line treatment in fit patients (i.e., those with a low burden of coexisting conditions) with advanced chronic lymphocytic leukemia (CLL) have been lacking. Methods In a phase 3, open-label trial, we randomly assigned, in a 1:1:1:1 ratio, fit patients with CLL who did not have TP53 aberrations to receive six cycles of che

Aims Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype data to identify mechanisms of AS. Methods and results A genome-wide meta-analysis of 11.6 million variants in 10 cohorts involving 653 867 European

Viable Escherichia coli were detected in sediments near a point of wastewater discharge in a marine coastal environment in Sweden. Since high concentrations were found in the sediments nearest the pipe, this suggested that treated wastewater effluent was the source of the microbes. In order to examine this hypothesis, different bioinformatics approaches were applied using 16S rRNA gene V3-V4 ampli

Objective: Vaspin (visceral adipose tissue derived serine protease inhibitor, SERPINA12) is associated with obesity-related metabolic traits, but its causative role is still elusive. The role of genetics in serum vaspin variability to establish its causal relationship with metabolically relevant traits was investigated. Methods: A meta-analysis of genome-wide association studies for serum vaspin f

The first measurements of elliptic flow of π ±, K ±, p + p ¯ , KS0 , Λ + Λ ¯ , ϕ, Ξ −+ Ξ ¯ + , and Ω −+ Ω ¯ + using multiparticle cumulants in Pb–Pb collisions at sNN = 5.02 TeV are resented. Results obtained with two- (v 2{2}) and four-particle cumulants (v 2{4}) are shown as a function of transverse momentum, p T, for various collision centrality intervals. Combining the data for both v 2{2} and

This chapter overviews migration management across Africa, arguing with Vigneswaran and Quirk (2015) that postcolonial African states prevent, promote, and channel migration for myriad political and economic purposes. While breaking from Eurocentric bias obsessed with Africa to Europe migration, we balance the view of African states not as dysfunctional European prototypes, nor as incomparable and

Lactic acid is a platform chemical that can be used for many applications. More recently, optically pure lactic acid—L- or D-lactic acid enantiomers—have been used for the polymerisation to poly-lactic acid (PLA). The possibility of tailoring the properties of this bioplastic by adjusting the ratio of each enantiomer might help to accelerate the substitution of petroleum-based plastics with bio-ba

To address the unmet need for scalable solutions for lifestyle treatment, we developed a new digital method to promote behavioral change. Here we report that patients with type-2 diabetes in Sweden (n = 331) exposed to the intervention have significantly improved HbA1c during a median follow-up of 1038 days (4 mmol/mol compared with matched controls; P = 0.009). This is paralleled by reduced body

Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone biology, particularly to intramembranous ossification, not captured at other skeletal sites. We perform a genome-wide association meta-analysis (n ~ 43,800) of SK-BMD, identifying 59 loci, collectively explaining 12.5% of the trait variance. Association signals cluster within gene-sets involved in

OBJECTIVE Latent autoimmune diabetes in adults (LADA) is a heterogenous, slowly progressing autoimmune diabetes. We aim to contribute new knowledge on the long-term prognosis of LADA with varying degrees of autoimmunity by comparing it to type 2 diabetes and adult-onset type 1 diabetes. RESEARCH DESIGN AND METHODS This Swedish population-based study included newly diagnosed LADA (n = 550, stratifi

BACKGROUND: The risk of SARS-CoV-2 infection among health care workers (HCWs) is a concern, but studies that conclusively determine whether HCWs are over-represented remain limited. Furthermore, methods used to confirm past infection vary and the immunological response after mild COVID-19 is still not well defined.METHOD: 314 HCWs were recruited from a Swedish Infectious Diseases clinic caring for

The transcriptional mechanisms underlying tooth development are only beginning to be understood. Pitx2, a bicoid-like homeodomain transcription factor, is the first transcriptional marker observed during tooth development. Because Pitx2, Msx2, and Dlx2 are expressed in the dental epithelium, we examined the transcriptional activity of PITX2 in concert with Msx2 and the Dlx2 promoter. PITX2 activat

Antigen-specific class-switched antibodies are detected at the same time or even before IgM in serum of non-vaccinated individuals infected with SARS-CoV-2. These derive from the first wave of plasmablasts formed. Hence, the phenotype and specificity of plasmablasts can reveal information about early B-cell activation. Here we have analyzed B cells and plasmablasts circulating in blood of COVID-19

The fate of tissue-resident memory CD4 T cells (Trm) has been incompletely investigated. Here we show that intranasal, but not parenteral, immunization with CTA1-3M2e-DD stimulated M2e-specific Th17 Trm cells, which conferred strong protection against influenza virus infection in the lung. These cells rapidly expanded upon infection and effectively restricted virus replication as determined by CD4

PURPOSE: Pharmacologic doses of corticosteroid (CS) have been shown to ameliorate the progression of Duchenne muscular dystrophy (DMD) preserving strength, pulmonary function and ambulation as well as reducing the incidence of scoliosis. However, there are serious side effects of CS, which may impact dose tolerance. The purpose of this study was to compare the magnitude of positive CS effects on p

BACKGROUND: [Corrected] Clinical assessment is not always sufficient to predict postoperative (PO) cardiac complications. B-type natriuretic peptide (BNP) has an important prognostic value in patients with heart failure. Its value as a predictor of events in orthopedic surgeries has not yet been tested.OBJECTIVE: To assess the value of BNP in predicting cardiac complications in the PO period of or

Modeller i arbetsterapi är en översiktlig grundbok som förklarar och sammanfattar några centrala arbetsterapeutiska modeller, Model of Human Occupation (MOHO), Canadian Model of Occupational Performance - Engagement (CMOP-E), Kawamodellen och Transactional Model of Occupation (TMO)Arbetsterapeuter arbetar med att stödja människor att få sitt dagliga liv att fungera, vilket ofta sker i konkreta sit

Artificial intelligence (AI) is emerging as an impactful feature of the life, planning and governance of 21st-century cities. Once confined to the realm of science fiction and small-scale technological experiments, AI is now all around us, in the shape of urban artificial intelligences including autonomous cars, robots, city brains and urban software agents. The aim of this article is to criticall