Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen hos västerländska kvinnor. I Sverige kommer var tionde kvinna att drabbas av bröstcancer, vilket motsvarar drygt 5000 kvinnor om året. Dödligheten i bröstcancer är 30%. Detta innebär att en tredjedel av de som drabbas kommer att dö av sin sjukdom. Det är dock inte själva tumören i bröstet som dödar eftersom denna i princip alltBreast cancer is one of the most common cancer forms in the industrialized world. Only in Sweden, nearly 6000 women are diagnosed with breast cancer each year and 1/3 of them eventually succumb to the disease. Wnts are a family of genes that have been implicated in many human tumours, so far mainly studied in colorectal cancer where activated Wnt signalling occurs in a vast majority of tumours. Wh

A receiver front-end supporting contiguous and non-contiguous intra-band carrier aggregation scenarios with a fully integrated spectrum sensor that can detect both in-gap and out-of-band blockers has been implemented in 65nm CMOS technology. An NF of 2.5dB is achieved using a noise canceling LNTA, and linearized OTAs are used to achieve an IIP3 improvement of up to 6.5dB in-band and 11dB at the fi

Kaposi's sarcoma-associated herpes virus (KSHV) encodes a complement inhibitor named KSHV complement control protein (KCP). We have previously shown that KCP inhibits the human complement system by disrupting the C3 convertase of complement. KCP can accelerate the decay of the classical C3 convertase and it can act as a cofactor for factor I (R), which then cleaves and inactivates C4b or C3b (in t

Chiral building blocks are needed in the chemical and pharmaceutical industries for the production of fine chemicals and pharmaceuticals. The utilisation of microorganisms and enzymes to perform stereoselective reductions of carbonyl compounds is an efficient and widely applied method for the generation of chiral molecules. The aim of this thesis was to develop and improve yeast-catalysed bioredu

Handledning är en praktik som under senare år kommit till användning inom en lång rad olika fält, allt ifrån utbildning inom skola, universitet och arbetsliv, professionell utveckling, organisations- och ledarutveckling till kultur- och fritidsverksamheter. Handledning - perspektiv och erfarenheter fokuserar på den bredd som finns inom ämnet, där varje fält hämtar idéer och arbetssätt från variera

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This thesis comprises ecological, morphological and physiological studies of the carrot psyllid Trioza apicalis (Homoptera: Psylloidea) with particular focus on olfaction. Data from inventories of winter habitats suggest that T. apicalis prefer Picea abies over Pinus sylvestris and Juniperus communis as winter hosts. Their migration range is at least I km, and we found no clear wind-borne pattern

The gene fusion technique is widely used in protein engineering and in this thesis it constitutes the basis of both the construction of artificial bifunctional enzymes and the display of two novel peptides. Artificial bifunctional enzymes have been used as model systems in the studies of native multifunctional enzymes and proximity effects within these complexes. Two various constructs are descri