Objective People with neuropsychiatric symptoms often experience delay in accurate diagnosis. Although cerebrospinal fluid neurofilament light (CSF NfL) shows promise in distinguishing neurodegenerative disorders (ND) from psychiatric disorders (PSY), its accuracy in a diagnostically challenging cohort longitudinally is unknown. Methods We collected longitudinal diagnostic information (mean=36 mon

In this study, we use an extension of the heterogeneous autoregressive model to investigate the influence of time-varying risk aversion and macroeconomic, financial, and economic policy uncertainty measures on stock market volatility and correlation. Based on the findings, there is a stronger predictive ability of these variables at the monthly frequency than at the daily frequency. We also highli

Humanity is facing an unprecedented challenge of climate crises. Rapid changes to the physical environment and living conditions will be accompanied by challenges to mental health and well-being. Consequently, education for sustainable development should also include coping strategies for stress and anxiety. Adding intra-personal skills to the curriculum, such as self-reflection and mindfulness tr

Sammanfattande kommentarer och rekommendation • Opioider och bensodiazepiner är kraftfulla läkemedel med god patientnytta i utvalda fall och under begränsade behandlingstider.• Läkare/vårdenhet som initierat förskrivning har ansvar för denna tills den upphört eller tills annaninstans accepterat övertag – Behandlingsansvar• Basbehandling – överväg alltid först alternativa behandlingsstrategier, såv

Extracorporeal membrane oxygenation (ECMO) occupies an increasingly important position in the clinic for the management of cardiac and/or pulmonary failure. As a rescue therapy, ECMO can support patients following respiratory or cardiac compromise to act as a bridge to recovery, to decision, or to transplant. This chapter reviews briefly the history of ECMO implementation as well as device modes,

Preeclampsia is a hypertensive disorder that is usually diagnosed after 20 weeks' gestation. Despite the deleterious effect of smoking on cardiovascular disease, it has been frequently reported that smoking has a protective effect on preeclampsia risk and biological explanations have been proposed. However, in this manuscript, we present multiple sources of bias that could explain this association

This article focuses on the quest for digitalisation in peace mediation and to the extent to which digital disruption is reshaping its practices. While digitalisation in the wider field of diplomacy has seen dramatic changes in its practices, peace mediation is a ‘latecomer’. The article explores the constitutive effects on specific norms and practices of peace mediation and identifies opportuniti

A significant proportion of COVID-19 patients experience debilitating symptoms for months after the acute infection. According to recent estimates, approximately one out of ten COVID-19 convalescents reports persistent health issues more than three months after initial recovery. This "post-COVID-19 condition" may include a large variety of symptoms from almost all domains and organs, and for some

Background: Energy citizenship has emerged as a concept which attempts to capture the new role envisaged for urban citizens as engaged and active in the energy transition. However, exactly how to successfully engage energy citizens requires more research and this article aims to contribute to this knowledge gap. The article presents a new methodology, ‘Walking with Energy’, which seeks to (re)conn

In man-made energy systems like the electricity system, new concepts have the potential to influence and shape the development of the system. Sometimes the influence leads to a positive development and in other cases the new concept may lead into disadvantageous pathways. In this paper we argue that when a new concept is introduced, it may give rise to an unhinged paradox. An unhinged paradox impl

Local flexibility markets (LFM) for electricity are in their early stages, and most research has focused on their design aspects and aggregators, while little attention has been paid to providers and potential providers of flexibility resources. The present research aims to fill this gap by analysing data from 25 in-depth interviews with enrolled and potential flexibility service providers of two

Många organisationer har i flera år försökt positionera sig som hållbara, men inte lyckats. Dels är det få kunder som uppmärksammar satsningarna, dels verkar det inte driva deras köpvilja. Nuvarande konjunkturläge gör inte heller hållbarhetsarbetet enklare. Vad kan man göra för att potentiella och nuvarande kunder ska uppmärksamma arbetet man gör och dessutom engagera sig i varumärkets hållbarhets

BACKGROUND: Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive and lethal disease, lacking effective therapeutic approaches. Available therapies only marginally prolong patient survival and are frequently coupled with severe adverse events. It is therefore pivotal to investigate novel and safe pharmacological approaches. We have recently identified the ABC transporter, ABCC3, whose expressio

OBJECTIVES: Occupational exposure to vibration using hand-held tools may cause hand-arm vibration syndrome (HAVS). Correct diagnosis and grading of severity are crucial in protecting the individual's health and for workers' compensation claims. The International Consensus Criteria (ICC) has been suggested to replace the widely used Stockholm Workshop Scale (SWS). The aims were to, in a clinical se

The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 years as very few and mostly just palliative treatments are available. As the five years survival rate remains around 5%, the identification of novel pharmacological targets and development of new therapeutic strategies are urgently needed. Here we demonstrate that inhibition of the G protein-coupled

Cancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attracts interest as a therapeutic target. In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. Here we investigated the charact