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Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs

Popular Abstract in Swedish Typ 2-diabetiker: söt som socker och rik på fett Det finns flera olika varianter av diabetes och den mest förekommande är typ 2-diabetes (T2D). T2D kallades förr i dagligt tal åldersdiabetes, men numera drabbas individer i alla åldrar. Sjukdomen kännetecknas av förhöjda nivåer av socker och fett i blodet, vilket beror på att kroppens celler har en nedsatt förmåga att tType 2 diabetes (T2D) is a heterogeneous disease characterized by altered lipid parameters and elevated glucose levels, as a direct consequence of impaired insulin signaling in target tissues and reduced insulin exocytosis from pancreatic β-cells. Obesity, which dramatically increases worldwide, is associated with insulin resistance and T2D. In this thesis, we elucidate the effects of hormones and

Hopping Conduction in Mn Ion-Implanted GaAs Nanowires.

We report on temperature-dependent charge transport in heavily doped Mn(+)-implanted GaAs nanowires. The results clearly demonstrate that the transport is governed by temperature-dependent hopping processes, with a crossover between nearest neighbor hopping and Mott variable range hopping at about 180 K. From detailed analysis, we have extracted characteristic hopping energies and corresponding ho

The quest to become a world city: Implications for access to water

The ambition to be recognized as a 'World City' or 'Global City' is rapidly increasing not the least among cities in the global south such as Hyderabad in India and Johannesburg in South Africa. While such a status seems promising for attracting foreign capital and for expanding the economic potential of urban areas, it may have adverse impacts on the hinterland and contribute to growing urban ine

Green qualities in the neighbourhood and mental health - results from a longitudinal cohort study in Southern Sweden

Background: Poor mental health is a major issue worldwide and causality is complex. For diseases with multifactorial background synergistic effects of person-and place-factors can potentially be preventive. Nature is suggested as one such positive place-factor. In this cohort study we tested the effect of defined green qualities (Serene, Space, Wild, Culture, Lush) in the environment at baseline o

Enhanced sputtering and incorporation of Mn in implanted GaAs and ZnO nanowires

We simulated and experimentally investigated the sputter yield of ZnO and GaAs nanowires, which were implanted with energetic Mn ions at room temperature. The resulting thinning of the nanowires and the dopant concentration with increasing Mn ion fluency were measured by accurate scanning electron microscopy (SEM) and nano-x-Ray Fluorescence (nanoXRF) quantification, respectively. We observed a cl

On common terms with shared risks - Studying the communication of risk between local, regional and national authorities in Sweden

Uncommon categorization, i.e. disparities in how similar terms and information is interpreted, coded and categorized, has been shown to impede inter-agency communication and collective sense-making. This study focuses on the presence and effects of uncommon categorizations in disaster risk management systems. We use the Swedish disaster risk management system as our case, and our empirical data co

Potential environmental impacts of using refuse derived material for landfill capping

In this study, the potential impacts on leachate emissions of applying a pretreated refuse-derived material as a capping layer on top of a municipal solid waste landfill were researched. Leachate emissions and stability against degradation were investigated with reference to the untreated material. Results from percolation leaching tests were analysed by multivariate data analysis and chemical spe

Lack of arbuscular mycorrhizal colonisation in tea (Camellia sinensis L.) plants cultivated in Northern Iran

Soil and roots associated with different tea clones and nearby weeds (Veronica sp., Setaria sp., Salvia sp., Senecio sp. and Tripogon sp.) were sampled for arbuscular mycorrhizal fungi (AMF) in the tea gardens of Northern Iran. Spores were searched for in the soil and AMF colonisation determined microscopically and fatty acid signatures in roots was determined. Root samples from mycorrhizal and no

Direct and mediated electron transfer between intact succinate:quinone oxidoreductase from Bacillus subtilis and a surface modified gold electrode reveals redox state-dependent conformational changes.

Succinate:quinone oxidoreductase (SQR) from Bacillus subtilis consists of two hydrophilic protein subunits comprising succinate dehydrogenase, and a di-heme membrane anchor protein harboring two putative quinone binding sites, Q(p) and Q(d). In this work we have used spectroelectrochemistry to study the electronic communication between purified SQR and a surface modified gold capillary electrode.

Global Optimization for One-Dimensional Structure and Motion Problems

We study geometric reconstruction problems in one-dimensional retina vision. In such problems, the scene is modeled as a two-dimensional plane, and the camera sensor produces one-dimensional images of the scene. Our main contribution is an efficient method for computing the global optimum to the structure and motion problem with respect to the L-infinity norm of the reprojection errors. One-dimens

High quality InAs and GaSb thin layers grown on Si (111)

We have investigated growth of thin epitaxial layers of InAs on Si (1 1 1) substrates by metalorganic vapor phase epitaxy (MOVPE) and successfully grown GaSb layers on InAs. Furthermore, we have studied the effect of growth temperature and material flow on the nucleation stage and also nucleated GaSb nanowires on the underlying GaSb layer. The InAs layers are grown by a standard two-step growth ap

Hereditary myopathy with early respiratory failure: occurrence in various populations

Objective Several families with characteristic features of hereditary myopathy with early respiratory failure (HMERF) have remained without genetic cause. This international study was initiated to clarify epidemiology and the genetic underlying cause in these families, and to characterise the phenotype in our large cohort. Methods DNA samples of all currently known families with HMERF without mole