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Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme

Human mitochondrial dihydroorotate dehydrogenase (the fourth enzyme of pyrimidine de novo synthesis) has been overproduced by means of a recombinant baculovirus that contained the human cDNA fragment for this protein. After virus infection and protein expression in Trichoplusia ni cells (BTI-Tn-5B1-4), the subcellular distribution of the recombinant dihydroorotate dehydrogenase was determined by t

Anti-peptide immunoglobulins from rabbit and chicken eggs recognise recombinant human dihydroorotate dehydrogenase and a 44-kDa protein from rat liver mitochondria

Mitochondrially bound dihydroorotate dehydrogenase catalyses the fourth sequential step in the de novo synthesis of uridine monophosphate. 312-bp and 983-bp regions of the human dihydroorotate dehydrogenase sequence (1496 bp) were amplified by the polymerase chain reaction, and subcloned into the expression vector pQE 32. The identity of the PCR products was verified by dideoxynucleotide sequencin

'Like Locusts on the Mississippi' : A Pioneer Study of the Expansion of the Swedish Public Sector

In 1962, the first thorough investigation into the expansion of the Swedish public sector was presented as a doctoral dissertation by Erik Höök. This article investigates the origin and reception of this thesis. Höök’s work has been consid ered a standard work of financial statistics. However, it attracted heavy criticism in the media and from other academics for having explained the public sector

Education and health : Long-run effects of peers, tracking and years

We investigate two parallel school reforms in Sweden to assess the long-run health effects of education. One reform only increased years of schooling, while the other increased years of schooling but also removed tracking leading to a more mixed socioeconomic peer group. By differencing the effects of the parallel reforms we separate the effect of de-tracking and peers from that of more schooling.

Fragmentation, commodification and responsibilisation in the governing of flood risk mitigation in Sweden

The purpose of this paper is to increase our understanding of the governing of flood risk mitigation in advanced liberal society, through an in-depth Swedish case study. By combining social network analysis and genealogy, this paper investigates who is involved, how they organise, their modes of thinking, how they mitigate flood risk, as well as how such regime of practises have come into being. T

A novel method for creatinine adjustment makes the revised Lund–Malmö GFR estimating equation applicable in children

The aim of this study was to establish creatinine growth curves separately for males and females that can be used to adjust childhood levels of serum creatinine to corresponding adult levels. Linear regression with fractional polynomials of age as independent variable was used to construct creatinine growth curves for a reference cohort (n = 83,157 samples from Belgium and Sweden, age 2–40 years).

Governing smart mobility : policy instrumentation, technological utopianism, and the administrative quest for knowledge

This article analyzes administrative practices in relation to the emergence of novel technologies. “Smart mobility” is an umbrella term used to denote the potentially disruptive changes in the transport sector relating to automatization, digitalization, and the platform economy. While this development is largely driven by industry, public administrations are engaging in a number of processes where

Heterogeneity of cancer-associated fibroblasts : Opportunities for precision medicine

Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor–cell-centric view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer-associated fibroblasts (CAFs) are attracting attention as a target fo

An integrated mental health and vocational intervention : A longitudinal study on mental health changes among young adults

Aim: This study aimed to investigate changes in mental health among young adults participating in an integrated mental health and vocational support intervention according to the Södertälje Supported Employment and Education model. Design: A prospective longitudinal pre–post intervention study of 12 months. Methods: Instruments on depressive symptoms, quality of life, empowerment, engagement in ac

Sovereign dupes? Representations, conventions and (un)sustainable consumption

If resource intensive practices are regularly represented as conventional, these potentially become naturalised and inconspicuous consumption will increase. Understanding how representations, conventions and everyday practices interact is thus fundamental in tackling unsustainable consumption. To gain new insights into how representations, conventions and practices interact, this paper explores ho

Elevated plasma endocan and BOC in heart failure patients decrease after heart transplantation in association with improved hemodynamics

Background: The prevalence of heart failure (HF) is rising with ageing population and constitutes a major health problem globally. A common complication of HF is pulmonary hypertension (PH) which negatively impacts survival. A pathophysiological association between HF and PH with tumorigenic processes has been suggested. We aimed to identify the plasma levels of, and the association between tumour

When Average Joe met the Inexperienced Superstar—a case study of the consequences for a university of a partnership with IKEA

The aim of this study was to explore how consequences from a university-wide partnership unfolded at various levels within a university and induced intra-organizational dynamics. This was achieved via an in-depth investigation of “The Bridge,” a collaborative partnership between the young mid-range Swedish Linnaeus University (“Average Joe”) and the home furnishing retail giant IKEA, which despite

Visual adaptations of diurnal and nocturnal raptors

Raptors have always fascinated mankind, owls for their highly sensitive vision, and eagles for their high visual acuity. We summarize what is presently known about the eyes as well as the visual abilities of these birds, and point out knowledge gaps. We discuss visual fields, eye movements, accommodation, ocular media transmittance, spectral sensitivity, retinal anatomy and what is known about vis

Regional evidence of smallholder-based growth in Zambia's livestock sector

Growth in the smallholder-based livestock sector, characterized by increasing number of animals, commercialization and processing of animal products have historically provided a decisive contribution to raising the incomes of farm households, and to the broader process of agricultural transformation. In this paper, we use a mixed methods approach to examine the processes of extensive and intensive

Identification and characterization of design fires and particle emissions to be used in performance-based fire design of nuclear facilities

CERN operates one of the most complex particle accelerator facilities in the world. Several different hazards, including fires, are present and need to be investigated and reduced to a tolerable level. Toward this goal, CERN aims at developing a catalog containing detailed fire dynamics descriptions of combustible items present in its facilities. This paper contributes to this catalog in two ways.

Persistence of avian haemosporidians in the wild : a case study to illustrate seasonal infection patterns in relation to host life stages

Infection patterns of avian haemosporidians result from the evolution of their associations with hosts, and can be shaped by multiple biotic factors. However, at the level of parasite species, few studies have investigated the details of the temporal dynamics of infection patterns in wild bird communities. We hereby studied a wild bird community in southern Sweden to investigate two generalist par

Numerical contribution to segmented chip effect on residual stress distribution in orthogonal cutting of Inconel718

Segmented chip morphology has a significant influence on distribution of residual stress and surface topography on machined surface in machining difficult-to-cut materials. In this paper, Coupled Eulerian and Lagrangian (CEL) model is employed to investigate the effect of segmented chip on surface integrity (residual stress distribution and surface topography) in orthogonal machining of Inconel718

The truths and falsehoods of post-truth leaders

Over the last three years, the idea of a ‘post-truth society’ has become a common talking point. Politicians from around the world, from Europe to South America to the United States, have been labelled as ‘post-truth leaders’, with Donald Trump being portrayed as the standard bearer for this new kind of political discourse. This article suggests that post-truth leadership is nothing new. Ever sinc

Fear of graft rejection after heart transplantation – a nationwide cross-sectional cohort study

Background: Cellular rejection is most common 3–6 months after heart transplantation while chronic rejection, that is, cardiac allograft vasculopathy and malignancy are the most common causes of death in heart-transplant recipients beyond the third year after transplantation. However, the heart transplantation recipient’s perceived threat of graft rejection has never been explored. Aim: The aim wa