OBJECTIVES: The objectives of this exploratory study were to investigate the feasibility of multidimensional diffusion magnetic resonance imaging (MddMRI) in assessing diffusion heterogeneity at both a macroscopic and microscopic level in prostate cancer (PCa).MATERIALS AND METHODS: Informed consent was obtained from 46 subjects who underwent 3.0-T prostate multiparametric MRI, complemented with a

PURPOSE: Diffusion-weighted MRI is sensitive to incoherent tissue motion, which may confound the measured signal and subsequent analysis. We propose a "motion-compensated" gradient waveform design for tensor-valued diffusion encoding that negates the effects bulk motion and incoherent motion in the ballistic regime.METHODS: Motion compensation was achieved by constraining the magnitude of gradient

Diffusion weighted imaging provides a unique tool to interrogate the microstructure of living tissue without the need for an invasive procedure. For timescales applicable in a clinical MRI setting, the diffusion process is sensitive to the structural configuration of tissue on the micrometer scale, i.e., the size of cells. Features such as the packing density of the cell matrix affect the overall

Diffusion-weighted magnetic resonance imaging (DW-MRI) is a non-invasive technique to probe tissue microstructure. Conventional Stejskal–Tanner diffusion encoding (i.e., encoding along a single axis), is unable to disentangle different microstructural features within a voxel; If a voxel contains microcompartments that vary in more than one attribute (e.g., size, shape, orientation), it can be diff

Spatial decision making is an everyday activity, common to individuals and organizations. However, recently there is an increasing interest in the importance of spatial decision-making systems, as more decision-makers with concerns about sustainability, social, economic, environmental, land use planning, and transportation issues discover the benefits of geographical information. Many spatial deci

With the purpose to increase the knowledge on human behaviour when evacuating along elevated platforms, an experiment was carried out at the subway station of Skarpnäck, Stockholm, in October 2016. The overall project objective was to develop basic data for guidelines regarding fire safety design concerning evacuation along elevated platforms. The experiment was designed as a group experiment divi

The atomic contributions to valence electronic structure for 37 ionic liquids (ILs) are identified using a combination of variable photon energy XPS, resonant Auger electron spectroscopy (RAES) and a subtraction method. The ILs studied include a diverse range of cationic and anionic structural moieties. We introduce a new parameter for ILs, the energy difference between the energies of the cationi

Context. The formation and evolution of the Galactic bulge and the Milky Way is still a debated subject. Observations of the X-shaped bulge, cylindrical stellar motions, and the presumed existence of a fraction of young stars in the bulge have suggested that it formed through secular evolution of the disk and not through gas dissipation and/or mergers, as thought previously. Aims. Our goal was to

This volume provides a comprehensive discussion and overview of urban resilience, including socio-ecological and economic hazard and disaster resilience. It provides a summary of state of the art thinking on resilience, the different approaches, tools and methodologies for understanding the subject in urban contexts, and brings together related reflections and initiatives.Throughout the different

In this paper, we study foreign ownership as a vehicle for transferring gender norms across international borders. Specifically, we analyze how the wage differential between men and women in Swedish firms is affected by the degree of gender inequality in the home country of foreign investors. The results suggest that gender norms of the home country matter—the gender wage gap in foreign-owned subs

The physics of charge separation in organic semiconductors is a topic of ongoing research of relevance to material and device engineering. Herein, we present experimental observations of the field and temperature dependence of charge separation from singlet excitons in PTB7 and PC71BM, and from charge-transfer states created across interfaces in PTB7/PC71BM bulk heterojunction solar cells. We obta

Epilepsy is one of the leading neurological disorders affecting not only patients who suffer from seizures but also people around them and society in general. The striking one third of patients not responding to pharmacological treatments implies the necessity of developing alternative options for controlling seizures in these individuals. Moreover, the possibility to stop the progression of the d

High-efficiency microfocusing of multi-keV X-rays at synchrotron sources is highly profitable for spatially resolved structural analysis of many kinds. Because radiation from synchrotron sources is typically elongated along the horizontal dimension, generating a microbeam that is isotropic in size requires a carefully designed optics system. Here we report on using a combination of a horizontally

We present a setup for producing and characterizing picosecond ultraviolet laser pulses for use in the MAX IV photocathode electron gun preinjector. Frequency-tripled laser pulses from a commercial laser system are shaped directly in the ultraviolet domain using a Fourier-domain pulse shaper. The pulses were characterized using a transient grating FROG. We discuss a proposed upgrade of the pulse s

The World Health Organization’s age-friendly city initiative emerged as a response to the intersecting global trends of population ageing and urbanisation. However, a third global trend—digitalisation—has largely been overlooked in research and policy making relating to age-friendly cities and communities. Within the context of a general shift towards online civic participatory activities, this ar

Fouling on heat exchanger surfaces can weaken the heat-transfer capability, increase the energy consumption, and even cause the failure of the whole system. In coaxial heat exchangers, spirally corrugated tubes perform better than smooth ones concerning heat transfer and antifouling. In this article, a parametric study on the antifouling performance of a six-start spirally corrugated tube is carri

In recruitment, promotion, admission, and other forms of wealth and power apportion, an evaluator typically ranks a set of candidates in terms of their perceived competence. If the evaluator is prejudiced, the resulting ranking will misrepresent the candidates’ actual ranking. This constitutes not only a moral and a practical problem, but also an epistemological one, which begs the question of wha