Search results

Filter

Filetype

Your search for "*" yielded 529926 hits

Heart age gap estimated by explainable advanced electrocardiography is associated with cardiovascular risk factors and survival

Aims: Deep neural network artificial intelligence (DNN-AI)-based Heart Age estimations have been presented and used to show that the difference between an electrocardiogram (ECG)-estimated Heart Age and chronological age is associated with prognosis. An accurate ECG Heart Age, without DNNs, has been developed using explainable advanced ECG (A-ECG) methods. We aimed to evaluate the prognostic value

Ancestral ecological regime shapes reaction to food limitation in the Least Killifish, Heterandria formosa

Populations with different densities often show genetically based differences in life histories. The divergent life histories could be driven by several agents of selection, one of which is variation in per-capita food levels. Its relationship with population density is complex, as it depends on overall food availability, individual metabolic demand, and food-independent factors potentially affect

Nuclear factor Y is a pervasive regulator of neuronal gene expression

Nervous system function relies on the establishment of complex gene expression programs that provide neuron-type-specific and core pan-neuronal features. These complementary regulatory paradigms are controlled by terminal selector and parallel-acting transcription factors (TFs), respectively. Here, we identify the nuclear factor Y (NF-Y) TF as a pervasive direct and indirect regulator of both neur

Hållbarhetsmärkning - möjligheter och svårigheter.

Europeiska unionens (EU) strategi Från jord till bord (EU-kommissionen, 2020) ämnar skapa ett rättvisare, hälsosammare och miljövänligare livsmedelssystem. En av många åtgärder som lyfts fram i strategin för att uppnå målen är att främja en hållbar livsmedelskonsumtion genom att göra det lättare för konsumenter att välja hälsosamma och hållbara livsmedel. EU-kommissionen vill därför skapa ett ramv

Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission : influence of sex

Background: Women are disproportionately affected by migraine, representing up to 75% of all migraine cases. This discrepancy has been proposed to be influenced by differences in hormone levels between the sexes. One such hormone is progesterone. Calcitonin gene-related peptide (CGRP) system is an important factor in migraine pathophysiology and could be influenced by circulating hormones. The pur

Interleukin-1 receptor accessory protein (IL-1RAP) : A magic bullet candidate for immunotherapy of human malignancies

IL-1, plays a role in some pathological inflammatory conditions. This pro-inflammatory cytokine also has a crucial role in tumorigenesis and immune responses in the tumor microenvironment (TME). IL-1 receptor accessory protein (IL-1RAP), combined with IL-1 receptor-1, provides a functional complex for binding and signaling. In addition to the direct role of IL-1, some studies demonstrated that IL1

Design multiple : how different configurations of participation matter in design practice

This article critically interrogates how participation is practiced during the design process. We present the findings of three different configurations of participatory design workshops, each involving a different stakeholder group (age researchers, care experts and older adults). Building on insights from Science and Technology Studies (STS), we reveal how, in design practice, different configur

Search for pair-produced vector-like top and bottom partners in events with large missing transverse momentum in pp collisions with the ATLAS detector

A search for pair-produced vector-like quarks using events with exactly one lepton (e or μ), at least four jets including at least one b-tagged jet, and large missing transverse momentum is presented. Data from proton–proton collisions at a centre-of-mass energy of s= 13 TeV , recorded by the ATLAS detector at the LHC from 2015 to 2018 and corresponding to an integrated luminosity of 139 fb - 1 ,

Friezes, Triangulations, and Trees

In this thesis, we focus on these three classes of objects: frieze patterns, polygon triangulations, and planar binary rooted trees. After proving that these objects are in pairwise bijective correspondence with each other, we introduce Catalan numbers through Dyck paths and prove that all these objects are Catalan objects. By studying the properties of triangulations and binary trees, we establis

RecView : an interactive R application for locating recombination positions using pedigree data

Background: Recombination reshuffles alleles at linked loci, allowing genes to evolve independently and consequently enhancing the efficiency of selection. This makes quantifying recombination along chromosomes an important goal for understanding how selection and drift are acting on genes and chromosomes. Results: We present RecView, an interactive R application and its homonymous R package, to f

Strain and phase evolution in TiAlN coatings during high-speed metal cutting : An in operando high-energy x-ray diffraction study

We report on phase and strain changes in Ti1-xAlxN (0 ≤ x ≤ 0.61) coatings on cutting tools during turning recorded in operando by high-energy x-ray diffractometry. Orthogonal cutting of AISI 4140 steel was performed with cutting speeds of 360–370 m/min. Four positions along the tool rake face were investigated as a function of time in cut. Formation of γ-Fe in the chip reveals that the temperatur

Evidence for the charge asymmetry in (Formula presented.) production at √s = 13 TeV with the ATLAS detector

Inclusive and differential measurements of the top–antitop (Formula presented.) charge asymmetry (Formula presented.) and the leptonic asymmetry (Formula presented.) are presented in proton–proton collisions at s = 13 TeV recorded by the ATLAS experiment at the CERN Large Hadron Collider. The measurement uses the complete Run 2 dataset, corresponding to an integrated luminosity of 139 fb−1, combin

XFEL Microcrystallography of Self-Assembling Silver n-Alkanethiolates

New synthetic hybrid materials and their increasing complexity have placed growing demands on crystal growth for single-crystal X-ray diffraction analysis. Unfortunately, not all chemical systems are conducive to the isolation of single crystals for traditional characterization. Here, small-molecule serial femtosecond crystallography (smSFX) at atomic resolution (0.833 Å) is employed to characteri

Effects of socioeconomic status on patient-reported outcome after surgically treated trigger finger : a retrospective national registry-based study

OBJECTIVES: To investigate if socioeconomic status impacts patient-reported outcomes after a surgically treated trigger finger (TF).DESIGN AND SETTING: Data on patients with TF treated with surgery were collected from the Swedish National Quality Registry of Hand Surgery (HAKIR) 2010-2019 with an evaluation of symptoms and disability before surgery and at 3 and 12 months after surgery, using the s

The limit point in the Jante's law process has an absolutely continuous distribution

We study a stochastic model of consensus formation, introduced in 2015 by Grinfeld, Volkov and Wade, who called it a multidimensional randomized Keynesian beauty contest. The model was generalized by Kennerberg and Volkov, who called their generalization the Jante's law process. We consider a version of the model where the space of possible opinions is a convex body B in Rd. N individuals in a pop

Density dependent environments can select for extremes of body size

Body size variation is an enigma. We do not understand why species achieve the sizes they do, and this means we also do not understand the circumstances under which gigantism or dwarfism is selected. We develop size-structured integral projection models to explore evolution of body size and life history speed. We make few assumptions and keep models simple: all functions remain constant across mod

Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases : a multinational cohort study

Background: It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption of UPFs with the risk of multimorbidity defined as the co-occurrence of at least two chronic diseases in an individual among first cancer at any site, cardiovascular disease, and type 2 diabetes.

Evidence for an L3 phase in ternary deep eutectics : composition-induced L3-to-Lα transition of AOT

Pure and hydrated deep eutectic solvents (DES) are proposed to form self-assembled nanostructures within the fluid bulk, similar to the bicontinuous L3 phase common for ionic liquids (ILs). Labelled choline chloride : urea : water DES were measured using small-angle neutron scattering (SANS), showing no long-range nanostructure. However, solutions of the surfactant AOT in this DES yielded scatteri