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Sekularismens blinda fläck
Chemotherapeutic intensity and survival differences in young patients with diffuse large B-cell lymphoma : a Swedish Lymphoma Registry study
Young patients with diffuse large B-cell lymphoma (DLBCL) are variably treated with rituximab combined with cyclophosphamide-doxorubicin-vincristine-prednisone (R-CHOP), CHOP-etoposide (R-CHOEP), and anthracycline-based regimens with the addition of high-dose cytarabine/methotrexate (R-HDA/M). Using the nationwide, population-based Swedish Lymphoma Registry, we evaluated outcome, by treatment and
Design of a randomized controlled trial of physical training and cancer (Phys-Can) - the impact of exercise intensity on cancer related fatigue, quality of life and disease outcome
Background: Cancer-related fatigue is a common problem in persons with cancer, influencing health-related quality of life and causing a considerable challenge to society. Current evidence supports the beneficial effects of physical exercise in reducing fatigue, but the results across studies are not consistent, especially in terms of exercise intensity. It is also unclear whether use of behaviour
Feasibility of patient specific aortic blood flow CFD simulation.
Patient specific modelling of the blood flow through the human aorta is performed using computational fluid dynamics (CFD) and magnetic resonance imaging (MRI). Velocity patterns are compared between computer simulations and measurements. The workflow includes several steps: MRI measurement to obtain both geometry and velocity, an automatic levelset segmentation followed by meshing of the geometri
Expanded national database collection and data coverage in the FINDbase worldwide database for clinically relevant genomic variation allele frequencies
FINDbase (http://www.findbase.org) is a comprehensive data repository that records the prevalence of clinically relevant genomic variants in various populations worldwide, such as pathogenic variants leadingmostly tomonogenic disorders and pharmacogenomics biomarkers. The database also records the incidence of rare genetic diseases in various populations, all in well-distinct data modules. Here, w
Narrow sieves for parameterized paths and packings
We present parameterized algorithms for the k-path problem, the p-packing of q-sets problem, and the q-dimensional p-matching problem. Our algorithms solve these problems with high probability in time exponential only in the parameter (k, p, q) and using polynomial space. The constant bases of the exponentials are significantly smaller than in previous works; for example, for the k-path problem th
The fourier dimension is not finitely stable
The Fourier dimension is not, in general, stable under finite unions of sets. Moreover, the stability of the Fourier dimension on particular pairs of sets is independent from the stability of the compact Fourier dimension.
Coffee, tea and melanoma risk : findings from the European Prospective Investigation into Cancer and Nutrition
In vitro and animal studies suggest that bioactive constituents of coffee and tea may have anticarcinogenic effects against cutaneous melanoma; however, epidemiological evidence is limited to date. We examined the relationships between coffee (total, caffeinated or decaffeinated) and tea consumption and risk of melanoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). EP
Effect of alertness on the vestibulo-ocular reflex and on the slow rise in optokinetic nystagmus in rabbits
The effect of alertness on the time constant of the vestibulo-ocular reflex (VOR) and the time constant of the slow rise of the optokinetic nystagmus (OKN) was studied in nine pigmented rabbits. When the rabbits were alerted by vibration, the time constant of the VOR was prolonged, and that of the slow rise in OKN was shortened, whereas the gain of VOR and OKN remained largely unaffected. These fi
Effect of alertness and visual attention on optokinetic nystagmus in humans
The effect of alertness and visual attention on optokinetic nystagmus (OKN) and optokinetic after-nystagmus (OKAN) was studied in 20 volunteers. Electroencephalographic (EEG) activity was recorded over the occipital lobe. Exposure to sound and vibration caused a significant increase in the mean slow-phase velocity of OKN, whereas its maximum slow-phase velocity remained unaffected. Vibration tende
Histologic characterization of stem cells in mammary epithelium and stroma
It is unknown whether native cells in benign breast tissue mediate risk of cancer.We therefore aimed to identify cell types in benign human mammary tissueimmunohistologically using markers of stemness and differentiation, and toinvestigate their possible associations with clinical risk factors for breast cancer.We found that cells that are integrated in benign epithelium and areimmunoreactive for
Green processes based on the extraction with pressurized fluids to obtain potent antimicrobials from Haematococcus pluvialis microalgae
In the present work, the antimicrobial activity of different pressurized liquid extracts obtained from Haematococcus pluvialis microalga was tested against several microorganisms of importance for the food industry (Escherichia coli, Staphylococcus aureus, Candida albicans and Aspergillus niger). Extractions were performed with hexane and ethanol at four different temperatures (50, 100, 150 and 20
A systematic study on the interactions between carnosic acid and ethylpyrrolidine methacrylate-methyl methacrylate copolymer in supercritical media
In the present work, a systematic study on the interactions between carnosic acid (potent natural antioxidant from rosemary) and ethylpyrrolidine methacrylate-methyl methacrylate (EPyM/MMA) copolymer (synthesized in our laboratory) has been performed using different spectroscopic and thermogravimetric techniques. By comparing data obtained for the reference sample (carnosic acid + copolymer) with
Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers
Introduction: We aimed to determine the added value of cerebrospinal fluid (CSF) to clinical and imaging tests to predict progression from mild cognitive impairment (MCI) to any type of dementia. Methods: The risk of progression to dementia was estimated using two logistic regression models based on 250 MCI participants: the first included standard clinical measures (demographic, clinical, and ima
Angle resolved photoelectron spectroscopy of two-color XUV-NIR ionization with polarization control
Electron emission caused by extreme ultraviolet (XUV) radiation in the presence of a strong near infrared (NIR) field leads to multiphoton interactions that depend on several parameters. Here, a comprehensive study of the influence of the angle between the polarization directions of the NIR and XUV fields on the two-color angle-resolved photoelectron spectra of He and Ne is presented. The resultin
A new formulation and analysis of a collapsing bubble with different content in a liquid induced during acoustic cavitation
Purpose - The purpose of this paper is to present numerical investigation of the gas/vapor bubble dynamics under the influence of an ultrasonic field to give a more comprehensive understanding of the phenomenon and present new results Design/methodology/approach - In order to formulate the mathematical model, a set of governing equations for the gas inside the bubble and the liquid surrounding it
Automated determination of Vinclozolin at the ppb level in aqueous samples by a combination of microporous membrane liquid-liquid extraction and adsorption chromatography
An automated system with microporous membrane liquid-liquid extraction (MMLLE) combined with HPLC has been designed for the determination of Vinclozolin in aqueous matrices. In MMLLE a porous hydrophobic membrane separates an aqueous phase from an organic phase. The pores are filled with the organic solvent. In this work, MMLLE was performed in a flow system and coupled on-line to normal phase HPL
Long-Term Studies of Fungicide Concentrations in Greenhouses. 1. Technique for Determining Surficial Foliar Residues of Fungicides with Vinclozolin and Triadimefon as Model Compounds.
A new analysis procedure for fungicides has been developed gearing toward estimation of worker exposure in greenhouses. The procedure includes sampling on leaves, glass, and polymers using vinclozolin and triadimefon as model substances and starts with solvation of the fungicides with ethanol from the surface. It proceeds by collection of the solution on disks of cloth, disk extraction with excess