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C-peptide in the classification of diabetes in children and adolescents.

C-peptide in the classification of diabetes in children and adolescents. Aim: To report C-peptide results in newly diagnosed patients and the relation to clinical diagnosis of diabetes. Methods: A nation-wide cohort, the Better Diabetes Diagnosis study was used to determine serum C-peptide at diagnosis in 2734 children and adolescents. Clinical data were collected at diagnosis and follow-up. C-pep

The effect of smoking on carotid intima-media thickness progression rate and rate of lumen diameter reduction.

The purpose of the study was to investigate the long-term associations between smoking habits, environmental tobacco smoke exposure (ETS), carotid intima-media thickness (IMT) progression rate, and rate of lumen diameter reduction in the carotid artery during a 16-year follow-up. Another objective was to investigate if an effect of smoking on progression rate could be explained by increased low gr

Analysis of crack formation and crack growth in concrete by means of fracture mechanics and finite elements

A method is presented in which fracture mechanics is introduced into finite element analysis by means of a model where stresses are assumed to act across a crack as long as it is narrowly opened. This assumption may be regarded as a way of expressing the energy adsorption GC in the energy balance approach, but it is also in agreement with results of tension tests. As a demonstration the method has

A comparison of technologies for carbon neutral passenger transport

In this study, the use of energy carriers based on renewable energy sources in battery-powered electric vehicles (BPEVs), fuel-cell electric vehicles (FCEVs), hybrid electric vehicles (HEVs) and internal combustion engine vehicles (ICEVs) is compared regarding energy efficiency, emission and cost. There is the potential to double the primary energy compared with the current level by utilising vehi

Improvement of intensive care unit sound environment and analyses of consequences on sleep: an experimental study

Objective: Uninterrupted sleep is of vital importance for restoration and regaining health. In intensive care units (ICUs) where recovering and healing is crucial, patients' sleep often is fragmented and disturbed due to noise from activities from oneself, other patients, and alarms. The aim of our study was to explore if sleep could be improved by modifying the sound environment in a way that is

"'We Can't Just Do It Any Which Way' – Objectivity Work among Swedish Prosecutors"

Objectivity is a principle widely acknowledged and honoured in contemporary society. Rather than treating objectivity as an a priori defined category to be tested empirically, I refer to the construction of objectivity as it is accomplished in practice as “objectivity work” and consider how Swedish prosecutors in interviews make and communicatively realize (i.e. “make real”) its claims. In analyzi

Force Controlled Assembly of Flexible Aircraft Structure

The use of industrial robots in the aircraft industry has been hampered by a combination of poor accuracy of the robots and poor calibration of the workcell, and also manufacturing variability in composite parts. A way to handle these difficulties is using force control. An experimental case where a semi-compliant rib is aligned to multiple surfaces is used as an example to show this. The constrai

Doing citizenship: the cultural origins of civic agency in the public sphere

This text makes the argument that to understand the communicative skills and other competencies associated with active citizenship in the public sphere, one must analyse cultural circumstances within everyday life. Citizens do not magically emerge, fully formed and ready to participate, at age 18; they - and their civic skills - are shaped by a variety of factors in the private sphere.

An adaptive mixed-signal narrowband interference canceller for wireline transmission systems

Narrowband radio transmitters like radio amateurs and broadcast radio stations are considered to be a serious problem for high-bitrate data transmission over twisted pairs. Due to its high power level, radio frequency interference (RFI) has the potential of overloading the receiver's analog-to-digital converter (ADC). Once the ADC is in saturation, any countermeasure taken in the digital domain wi

A randomized study comparing manual lymph drainage with sequential pneumatic compression for treatment of postoperative arm lymphedema

We compared manual lymph drainage (MLD) with sequential pneumatic compression (SPC) for treatment of unilateral arm lymphedema in 28 women previously treated for breast cancer. After 2 weeks of therapy with a standard compression sleeve (Part I) with maintenance of a steady arm volume, each patient was randomly assigned to either one of two treatment regimens (Part II). MLD was performed according

Social impact assessments (SIA) in larger infrastructure investments in Sweden; the view of experts and practitioners

This paper, by highlighting the experiences and reflections of experts and practitioners, aims to increase knowledge of how social impact assessment is managed and handled at various stages of the planning process in major infrastructure investments in Sweden. Interviews were conducted with nine experts and practitioners working with issues of transport planning and social sustainability. The info

The protective role of ROS in autoimmune disease.

For a long time, reactive oxygen species (ROS) produced by the phagocyte NADPH oxidase (NOX2) complex have been considered harmful mediators of inflammation owing to their highly reactive nature. However, there are an increasing number of findings suggesting that ROS produced by the NOX2 complex are anti-inflammatory and prevent autoimmune responses, thus challenging existing dogma. ROS might not

Acute myeloid leukemia in the real world: why population-based registries are needed.

Population-based registries may provide data complementary to that from basic science and clinical intervention studies, all of which essential for establishing recommendations for the management of patients in the real world. The same quality criteria apply for the evidence-based label, and both high representation and good data quality are crucial in registry studies. Registries with high covera

Frequent alterations of the PI3K/AKT/mTOR pathways in hereditary nonpolyposis colorectal cancer.

The phosphatidylinositol 3-kinases-AKT-mammalian target of rapamycin pathway (PI3K/AKT/mTOR) is central in colorectal tumors. Data on its role in hereditary cancers are, however, scarce and we therefore characterized mutations in PIK3CA and KRAS, and expression of PIK3CA, phosphorylated AKT, and PTEN in colorectal cancers linked to hereditary nonpolyposis colorectal cancer (HNPCC). Sequencing was

Diffusion-weighted MRI measurements on stroke patients reveal water-exchange mechanisms in sub-acute ischaemic lesions.

The aim of this study was to investigate the diffusion time dependence of signal-versus-b curves obtained from diffusion-weighted magnetic resonance imaging (DW-MRI) of sub-acute ischaemic lesions in stroke patients. In this case series study, 16 patients with sub-acute ischaemic stroke were examined with DW-MRI using two different diffusion times (60 and 260 ms). Nine of these patients showed suf

Reduced expression of CYLD in human colon and hepatocellular carcinomas

CYLD was originally identified as a tumor suppressor that is mutated in familial cylindromatosis. Recent studies suggested a role for CYLD in nuclear factor-kappaB (NF-kappaB) regulation. NF-kappaB activation has been connected with multiple aspects of oncogenesis but the underlying molecular mechanisms of persistent NF-kappaB activation in tumors remain largely unknown. Thus, we evaluated CYLD tr