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Serine proteases of the S1 family have maintained a common structure over an evolutionary span of more than one billion years, and evolved a variety of substrate specificities and diverse biological roles, involving digestion and degradation, blood clotting, fibrinolysis and epithelial homeostasis. We here show that a wide range of C-terminal peptide sequences of serine proteases, particularly fro

During recent years, dipeptidyl peptidase-4 (DPP-4) inhibition has been included in the clinical management of type 2 diabetes, both as monotherapy and as add-on to several other therapies. DPP-4 inhibition prevents the inactivation of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). This results in stimulation of insulin secretion and

A concept that lies at the heart of political rhetoric is that of ‘workfare’. The issue, however, is what types of arguments have been invoked to assert the value of the concept. During the 1960s and 1970s, extensive criticism emerged towards a working life that was said to hinder women’s emancipation; a working life that wasted resources and had a negative impact on the environment; a working lif

Patients with incidentally detected adrenal adenomas may have subclinical hypercortisolism. We hypothesized that impaired renal function could lead to increased cortisol levels in these patients.

In this study, vegetation optical depth from ESA's Soil Moisture and Ocean Salinity (SMOS) satellite mission is combined with other existing remote sensing, meteorological and literature data in order to obtain values of gravimetric vegetation water content (M-g). The methodology combines an effective medium model valid at passive microwave frequencies with a vegetation dielectric constant model.

Abstract in UndeterminedWe characterized the composition and mechanical properties of cortical bone during maturation and growth and in adult life in the rabbit. We hypothesized that the collagen network develops earlier than the mineralized matrix. Growth was monitored, and the rabbits were euthanized at birth (newborn), and at 1, 3, 6, 9, and 18 months of age. The collagen network was assessed b

The present response time study investigated how a hypothesized time-based working memory constraint of 2–3 s affects the resolution of grammatical and semantic dependencies. Congruent and incongruent object relative (OR) and subject relative sentences were read at different presentation rates so that the distance between dependent words was either shorter or longer than 2–3 s. Incongruent OR sent

Little is known about the nature of post mortem degradation of proteins and peptides on a global level, the so-called degradome. This is especially true for non-neural tissues. Degradome properties in relation to sampling procedures on different tissues are of great importance for the studies of for instance post translational modifications and/or the establishment of clinical biobanks. Here, snap

Objective The theory behind the Job Content Questionnaire (JCQ) presumes that the "objective" social environment is measurable via self-report inventories such as the JCQ. Hence, it is expected that workers in identical work will respond highly similar. However, since no studies have evaluated this basic assumption, we decided to investigate whether workers performing highly similar work also resp

Angle-resolved photoemission spectroscopy reveals pronounced kinks in the dispersion of the sigma band of graphene. Such kinks are usually caused by the combination of a strong electron-boson interaction and the cutoff in the Fermi-Dirac distribution. They are therefore not expected for the sigma band of graphene that has a binding energy of more than approximate to 3.5 eV. We argue that the obser

The title compound, Ca5Pd6Ge6, was obtained during a systematic investigation of the Ca-Pd-Ge ternary phase diagram. The crystal structure was determined and refined from single-crystal X-ray diffraction data. It crystallizes in a new structure variant of the Y4PdGa12-type structure (Im3̅m, a = 8.7764(4) Å) that features an arrangement of vertex-sharing body-centered cubes of calcium, Ca@Ca8, with

INTRODUCTION: Many studies have focused on short term mortality after primary intracerebral haemorrhage (ICH) whereas long term prognosis and causes of death have been less studied. We therefore examined these issues in a population based cohort of 1 year ICH survivors. METHODS: ICH patients in a defined Swedish population (1.14 million inhabitants) were prospectively registered during 1996. Patie

The ability of von Willebrand factor (VWF) to bind platelet GP Ib and promote platelet plug formation is measured in vitro using the ristocetin cofactor (VWF:RCo) assay. Automated assay systems make testing more accessible for diagnosis, but do not necessarily improve sensitivity and accuracy.

The stability of the Nyström method for the Sherman-Lauricella equation on contours with corner points $c_j$, $j=0,1,...,m$ relies on the invertibility of certain operators $A_{c_j}$ belonging to an algebra of Toeplitz operators. The operators $A_{c_j}$ do not depend on the shape of the contour, but on the opening angle $\theta_j$ of the corresponding corner $c_j$ and on parameters of the approxim

A decreased ability to degrade neutrophil extracellular traps (NETs) is seen in a subgroup of patients with systemic lupus erythematosus (SLE) and correlates with the presence of autoantibodies. Antiphospholipid syndrome (APS) can develop secondary to SLE or as a primary disease. In the current study we investigated the ability of sera from patients with APS to degrade NETs. The presence of antibo

In the present work, the Yang-Mills (YM) quantum-wave excitations of the classical homogeneous YM condensate have been studied in quasi-classical approximation. The formalism is initially formulated in the Hamilton gauge and is based upon canonical quantisation in the Heisenberg representation. This canonical framework is then extended and related to YM dynamics in arbitrary gauge and symmetry gro

The stability of eyewitness confidence judgments over time in regard to their reported memory and accuracy of these judgments is of interest in forensic contexts because witnesses are often interviewed many times. The present study investigated the stability of the confidence judgments of memory reports of a witnessed event and of the accuracy of these judgments over three occasions, each separate

In cardiac surgery, postoperative low cardiac output has been shown to correlate with increased rates of organ failure and mortality. Catecholamines have been the standard therapy for many years, although they carry substantial risk for adverse cardiac and systemic effects, and have been reported to be associated with increased mortality. On the other hand, the calcium sensitiser and potassium cha

This paper examines how employees respond to managements’ conflicting use of technocratic forms of control to ensure efficiency and socio-ideological control to produce an ‘on brand’ employee identity. The paper proposes a portrait-based form of ethnography as a way to illustrate both commonalities and differences in employees’ identity work and responses to managerial control within the call cent