Aim: Polypharmacy is becoming a global health problem. The aims of this study were to evaluate the temporal trends in the prevalence of polypharmacy in Sweden and to explore polypharmacy disparities by age, gender, education, and immigration status. Methods: Polypharmacy and excessive polypharmacy were evaluated using data extracted from the Swedish Prescribed Drug Register between 2006 and 2014.

This Letter presents for the first time radio frequency (RF) reliability studies of fully integrated CMOS RF integrated circuits (RFICs) for next generation wireless communication applications involving conformal bodies where wireless communication RFICs will be embedded on ultra-thin flexible packages. As a test case, RF characteristics of a CMOS voltage-controlled oscillator (VCO) chip with mult

The clinical outcomes of primary immunodeficiencies (PIDs) are greatly improved by accurate diagnosis early in life. However, it is not common to consider PIDs before the manifestation of severe clinical symptoms. Including PIDs in the nation-wide newborn screening programs will potentially improve survival and provide better disease management and preventive care in PID patients. This calls for t

Adult health is influenced by factors during fetal life affecting organ development and birth weight. We aimed to study such factors in relation to adult respiratory disease (ARD) risk. The Helsingborg Birth Cohort, Sweden, contributed baseline data collected by medical staff through clinical examination and questionnaires on maternal and birth characteristics 1964-1967. Register linkages were per

Carriers of the hydroxysteroid 17-β dehydrogenase 13 (HSD17B13) gene variant (rs72613567:TA) have a reduced risk of NASH and cirrhosis but not steatosis. We determined its effect on liver histology, lipidome, and transcriptome using ultra performance liquid chromatography-mass spectrometry and RNA-seq. In carriers and noncarriers of the gene variant, we also measured pathways of hepatic fatty acid

Traumatic brain injury (TBI) constitutes a global epidemic. Overall outcome is poor, with mortality ranging from 10 to 70% and significant long-term morbidity. Several experimental reports have claimed effect on traumatic edema, but all clinical trials have failed. Antisecretory factor, an endogenous protein, is commercially available as Salovum®, which is classified as a medical food by the Europ

Although teachers’ well-being and vocal health are affected by noise, research on classroom sound environment from the teachers’ perspective is scarce. This study investigated the relationship between teachers’ well-being and classroom acoustics. The possible influence of teachers’ age, experience, teaching grade and class size on the relationship was also investigated. In this study, well-being r

Malignant melanoma is among the most aggressive skin cancers and it has among the highest metastatic potentials. Although surgery to remove the primary tumor is the gold standard treatment, once melanoma progresses and metastasizes to the lymph nodes and distal organs, i.e., metastatic melanoma (MM), the usual outcome is decreased survival. To improve survival rates and life span, advanced treatme

The ambition to keep global warming well below 2°C above pre-industrial levels, as recognised in the Paris Agreement, implies a reorientation towards low-carbon societal development and, ultimately, the decarbonisation of human societies and economies. While climate policy has been geared towards achieving set emission reduction targets, the decarbonisation of key socioeconomic sectors such as ene

Decrease of saline lakes, which comprise 44% of all available lake water, is a major concern. It additionally accelerates the desertification process of the region. Thus, various countries have taken different actions in protecting their lake water levels. The aim of this paper is to assess different strategies directed to tackle the decreased lake water levels in Lake Urmia and the Aral Sea, whic

Adopting a voluntary simplicity lifestyle (VSL) contributes to a change in consumption patterns towards more sustainable ones, which is urgently needed. This study defines the VSL as a voluntary reduction of income and consumption in exchange for more free time. Our research aims to contribute with more detailed VSL criteria. A literature review develops initial VSL criteria, which are validated a

OBJECTIVES: Joint destruction is a hallmark of juvenile idiopathic arthritis (JIA). Clinical evaluation and radiographic imaging are current methods to identify destruction. Biomarkers could aid an earlier and more sensitive diagnosis. Our aim was to investigate levels of bone and cartilage degradation biomarkers in JIA patients, compared to healthy children or juveniles with knee injuries. METHOD

Aims. We study the origin of tail-like structures recently detected around the disk of SU Aurigae and several FU Orionis-type stars. Methods. Dynamic protostellar disks featuring ejections of gaseous clumps and quiescent protoplanetary disks experiencing a close encounter with an intruder star were modeled using the numerical hydrodynamics code FEOSAD. Both the gas and dust dynamics were taken int

Among the existing estimators of factor-augmented regressions, the CCE approach is the most popular. A major reason for this popularity is the simplicity and good small-sample performance of the approach, making it very attractive from an empirical point of view. The main drawback is that most of the available asymptotic theory is based on quite restrictive assumptions, such as that the common fac

Monolithic integration of III-V semiconductors with Silicon technology has instigated a wide range of new possibilities in the semiconductor industry, such as combination of digital circuits with optical sensing and high-frequency communication. Dissimilarities in the crystal structure symmetry and large lattice mismatch between III-V’s and Si are the challenges that prevent direct epitaxial growt

Under Corona-krisen har digitaliseringen på vissa områden forcerats fram. Vi har intervjuat Stefan Larsson, docent i teknik och social förändring om digitaliseringens och plattformarnas roll, pandemiappar och hur vi kan förstå datainsamling och integritetsskyddsfrågor i relation till krisen.

The possibility of autonomous artificially intelligent systems (AAIs) has awaken a well-known worry in the scientific community as well as in popular imaginary: the possibility that beings which have gained autonomous intelligence either turn against their creators or at least make the moral and ethical superiority of creators with respect to the created questionable. The present paper argues that