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Individuals (n = 18) in remission from acute leukemia or highly malignant lymphoma were asked to narrate their lived experience of falling ill, of being under treatment, and life following this event. The transcribed texts were analyzed from a phenomenological-hermeneutic perspective, expanded by their medical and social history as related in interviews. The analysis revealed 3 themes: (I) Believe
A procedure for obtaining quantitative wave and morphodynamic data in a laboratory setting using video images has been developed. The steps include image capture, rectification, and data extraction. All the necessary steps were maintained within the MATLAB environment so the process was streamlined and large amounts of data processed. The procedure involves the use of a program to rectify images,
OBJECTIVE: Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease often clustered in families. We investigated the association between MHC haplotypes and SLE in multicase Caucasian families. METHODS: Ten consecutive families with 2 or more patients with SLE, in total 27 patients among 66 individuals, were studied. MHC haplotypes were determined by typing for HLA-A, B, C, DR, and DQ
Changes in Faroese land surfaces during the late Holocene reflect intimate interactions between cultural and environmental development. Analyses of fossil wood, pollen and plant macrofossils indicate that the present open landscape replaced shrubby vegetation that was present from c. 6000 BC Up to c. AD 660. Conditions altered during the late Holocene, with loss of woody vegetation and increasing
The complex 2,6-bis[(di-t-butylphosphino)methyl]phenyl allyl palladium ((PCPPd)-Pd-tBu-allyl, 3) reacts with CO2 in a very fast insertion reaction to give the corresponding butenoate complex. The reaction is thought to occur via a cyclic six-membered transition state (7), where the gamma-carbon of the allyl group is linked up with the CO2-carbon. A group of related PCP complexes were investigated
We have earlier shown that the rat neural progenitor cell line HiB5 is capable of suppressing intracranial growth of glioma cells in Fisher rats. Unlike some neural progenitor cells, HiB5 cells have not shown homing capacity towards glioma cells growing intracranially. In this study, we have genetically modified HiB5 progenitor cells to over-express the chemokine receptor CXCR3. We show that the i
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease linked to the misfolding of Cu/Zn superoxide dismutase (SOD1). ALS-related defects in SOD1 result in a gain of toxic function that coincides with aberrant oligomerization. The structural events triggering oligomerization have remained enigmatic, however, as is the case in other protein-misfolding diseases. Here, we target the criti
Breast cancer susceptibility genes BRCA1 and BRCA2 are tumour suppressor genes the alleles of which have to be inactivated before tumour development occurs. Hereditary breast cancers linked to germ-line mutations of BRCA1 and BRCA2 genes almost invariably show allelic imbalance (Al) at the respective loci. BRCA1 and BRCA2 are believed to take part in a common pathway in maintenance of genomic inte
The difference between a presumed distribution of flamelet position and a numerically simulated distribution of distance function (a signed distance to flamelet) is investigated. It is shown that even if the distribution of flamelet position is symmetrical and close to Gaussian, the distribution of distance function away from the mean flame position is skewed towards the mean position and the mean
Physiological integration between ramets is beneficial when acquiring heterogeneously distributed resources, and is hypothesized to occur when the benefits of resource sharing outweigh the costs. Our aim was to investigate if resource availability affected physiological integration in Carex arenaria and Carex disticha. Ramet systems were grown in high potassium and high water (K+ W+), high K and l
Alpha1-microglobulin (alpha1m) is a small glycoprotein with immunomodulatory properties. It is a member of the lipocalin family, a group of proteins that exhibit a well-conserved three-dimensional structure despite low sequence identity and that are known to bind small hydrophobic ligands. The types of ligands carried by alpha1m are still unknown, but it is known that this protein has yellow-brown
Antibody inhibition and alpha6beta1 ligand binding experiments indicate that the egg integrin alpha6beta1 functions as a receptor for sperm during gamete fusion; yet, eggs null for the alpha6 integrin exhibit normal fertilization. Alternative integrins may be involved in sperm-egg binding and fusion and could compensate for the absence of alpha6beta1. Various beta1 integrins and alphav integrins a
We study the nature of the [Ti II] and [Ni II] emission from the so-called strontium filament found in the ejecta of eta Carinae. To this purpose, we employ multilevel models of the Ti II and Ni II systems, which are used to investigate the physical condition of the filament and the excitation mechanisms of the observed lines. For the Ti II ion, for which no atomic data were previously available,
In this paper we study the adsorption at cationic emulsion droplets of starch which had been hydrophobically modified with octenyl succinic anhydride (OSA), a modification which also renders the starch anionic. Emulsions were formed with didodecyldimethylammonium bromide (DDAB) after which the OSA-starch was added. The emulsions were separated by centrifugation and the surface load of OSA-starch w
Clonal strains of the dinoflagellate Gymnodinium nolleri Ellegaard and Moestrup were intercrossed to determine if cyst-related traits are genetically regulated and to clarify unknown aspects in the sexuality of this species. The objectives were to determine whether the parental identity influenced the physiological and morphological aspects of the cyst offspring, and to describe and compare nuclea
Glucose-induced insulin secretion in response to a step increase in blood glucose concentrations follows a biphasic time course consisting of a rapid and transient first phase followed by a slowly developing and sustained second phase. Because Type 2 diabetes involves defects of insulin secretion, manifested as a loss of first phase and a reduction of second phase, it is important to understand th
Neurofibroma is a benign tumor originating from Schwann cells in peripheral nerve sheaths and may occur as a sporadic tumor or as part of the dominantly inherited tumor syndrome NF1. NF1 is caused by constitutional mutations in the NF1 gene, located in chromosome band 17q11 Whereas the involvement of the NF1 gene in neurofibroma development in NF1 patients has been fairly well characterized, the s
PURPOSE: To evaluate the results of primary stenting in aortic occlusive disease. METHODS: Thirty patients underwent primary stenting of focal concentric (n = 2) and complex aortic stenoses (n = 19), and aortic or aorto-iliac occlusions (n = 9). Sixteen patients underwent endovascular outflow procedures, three of whom also had distal open surgical reconstructions. Median follow-up was 16 months (r
