We sought to identify factors related to short-term outcome of foot ulcers in patients with diabetes treated in a multidisciplinary system until healing was achieved. Consecutively presenting patients with diabetes and worst foot ulcer (Wagner grade 1-5, below ankle) (n = 2,511) were prospectively followed and treated according to a standardised protocol until healing was achieved or until death.

While individual data form the base for much empirical analysis in education, this is not the case for analysis of technical efficiency. In this paper, efficiency is estimated using individual data which is then aggregated to larger groups of students. Using an individual approach to technical efficiency makes it possible to carry out studies on a wide range of student constellations; e.g. entire

EXAFS spectroscopy was used to study Pb(II) and Hg(II) adsorption complexes on goethite (alpha-FeOOH) in the presence of Cl-. At pH 7, the dominant Pb(II) species are bonded to edges of FeO6 octahedra and are similar to complexes that occur in the absence of Cl-. At pH less than or equal to 6, Pb(II)-chloro ternary complexes predominate and are bonded to corners of FeO6 octahedra. At pH 6.5, linea

The neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is essential for synaptic vesicle exocytosis, but its study has been limited by the neonatal lethality of murine SNARE knockouts. Here, we describe a viable mouse line carrying a mutation in the b-isoform of neuronal SNARE synaptosomal-associated protein of 25 kDa (SNAP-25) The causative I67T missens

Stable oxygen and carbon isotope data from a lacustrine sequence at Graenge, southeast Denmark, revealed distinct environmental changes related to Late Weichselian climatic development in the region. Comparison of isotopic records obtained from sedimentary carbonates and freshwater molluscs enabled reconstruction of changes in the lacustrine environment. The degree of thermal and chemical stratifi

BACKGROUND. Patients with the familial syndrome hereditary nonpolyposis colorectal carcinoma (HNPCC) exhibit air increased risk for several tumor types, of which the greatest lifetime risk is for colorectal and endometrial carcinoma. HNPCC is caused by a germline mutation in one of several identified mismatch repair (MMR) genes and typically presents with microsatellite instability (MSI) and frequ

Platelets contain growth factors that are believed to stimulate early fracture repair. Autologous platelets can be sequestered, concentrated, and mixed with thrombin to yield a so-called autologous growth factor gel, which might enhance bone repair or bone graft incorporation. The effect of this platelet concentrate on total tissue and bone ingrowth into porous coralline hydroxyapatite was studied

Recent evidence for efficient delivery of macromolecules, such as peptides and nucleic acids, from the cell exterior to the nucleus offers the interesting possibility of developing novel treatments directed at intranuclear targets. The findings should also stimulate the search for physiological ligands that utilize similar transport mechanisms to regulate pathobiological processes. Cytokines, grow

OBJECTIVE. To investigate the distribution and production of alpha 1-antichymotrypsin (ACT) and prostate-specific antigen (PSA) in benign hyperplastic and malignant prostatic tissue, respectively. METHODS. Using monoclonal anti-ACT and anti-PSA IgGs for immunocytochemistry and alkaline phosphatase conjugated 30-mer oligodeoxynucleotide probes for nonradioactive in situ hybridization, tissue specim

The sign of the T-stress has been widely used for deciding whether directional stability prevails for straight cracks subjected to mode I loading under small scale yielding. However, there is little evidence for the reliability of such a criterion. On the contrary, it is shown that a local criterion is not applicable and that directional stability generally depends on body and load geometry as wel

Geological evidence from the Late Cretaceous continental interior of the Vilui Basin, Siberia suggests a far wetter, warmer, and more equable annual climate than General Circulation Models (GCMs) can reproduce. The disparity cannot be bridged by the uncertainties inherent in either the models or the geological climate proxies. This implies the mismatch is genuine and that either 1) we have systema

Long-term data from standardized monitoring programmes at bird observatories are becoming increasingly available. These data are frequently used for detecting changes in the timing of bird migration that may relate to recent climate change. We present an overview of problematic issues in the analysis of these data, and review approaches to and methods for characterizing bird migration phenology an

BACKGROUND: Obesity has, in a number of studies, been found to correlate to disability and mortality, primarily due to diseases of the circulatory and musculoskeletal systems. In addition, an excess mortality among underweight subjects has been observed in previous studies. METHODS: Five complete birth-year cohorts (1926-1930) of male residents in Malmo (n = 7697) were invited to the survey at the

Breast cancer patients with c-erbB-2-positive tumours seem to benefit from anthracycline-based adjuvant chemotherapy. The predictive value of c-erbB-2 for taxane sensitivity is not yet clear. The purpose of this study was to assess whether c-erbB-2 expression is associated with clinical sensitivity to docetaxel (T) or sequential methotrexate and 5-fluorouracil (MF). A total of 283 patients with me

Biodegradable macroporous cryogels with highly open and interconnected pore structures were produced from dextran modified with oligo L-lactide bearing hydroxyethylmethacrylate (HEMA) end groups in moderately frozen solutions. Tissue responses to these novel scaffolds were evaluated in rats after dorsal subcutaneous implantation, iliac submuscular implantation, auricular implantation, or in calvar