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Previous SARS-CoV-2 infections and their impact on the protection from reinfection during the Omicron BA.5 wave – a nested case-control study among vaccinated adults in Sweden

Objectives: We evaluated the protection afforded by SARS-CoV-2 infection-induced immunity against reinfection among working-age vaccinated individuals during a calendar period from June to December 2022 when Omicron BA.5 was the dominating subvariant in Scania County, Sweden. Methods: The study cohort (n = 71,592) mainly consisted of health care workers. We analyzed 4144 infected cases during the

Sex differences in outcomes after revascularization for acute lower limb ischemia : Propensity score adjusted analysis

Background: Previous reports have suggested higher rates of mortality and amputation for female patients in acute lower limb ischemia (ALI). The aims of the present study were to investigate if there is a difference in mortality, amputation, and fasciotomy between the sexes. Methods: A retrospective cohort study of consecutive patients undergoing index revascularization for ALI between 2001 and 20

In vivo MRI and PET imaging in a translational ILD mouse model expressing non-resolving fibrosis and bronchiectasis-like pathology after repeated systemic exposure to bleomycin

Drug-induced interstitial lung disease (ILD) is crucial to detect early to achieve the best treatment outcome. Optimally, non-invasive imaging biomarkers can be used for early detection of disease progression and treatment follow-up. Therefore, reliable in vivo models are warranted in new imaging biomarker development to accelerate better-targeted treatment options. Single-dose bleomycin models haMethods: Drug-induced interstitial lung disease (ILD) is crucial to detect early to achieve the best treatment outcome. Optimally, non-invasive imaging biomarkers can be used for early detection of disease progression and treatment follow-up. Therefore, reliable in vivo models are warranted in new imaging biomarker development to accelerate better-targeted treatment options. Single-dose bleomycin

Kilometre-scale simulations over Fennoscandia reveal a large loss of tundra due to climate warming

The Fennoscandian boreal and mountain regions harbour a wide range of vegetation types, from boreal forest to high alpine tundra and barren soils. The area is facing a rise in air temperature above the global average and changes in temperature and precipitation patterns. This is expected to alter the Fennoscandian vegetation composition and change the conditions for areal land use such as forestry

Nurse assistants’ experiences of encountering patients in grief due to the death of a loved one - a qualitative study in municipal health and social care

Purpose: The aim was to explore nurse assistants´ experiences of paying attention to and encountering patients receiving municipal health and social care, who are in grief due to the death of a loved one. Methods: A qualitative study with focus group interviews (n = 6) was conducted with nurse assistants (NAs) (n = 28) in municipal health and social care (n = 5) in southern Sweden. The data were a

Small but mighty : High-resolution spectroscopy of ultra-hot Jupiter atmospheres with compact telescopes Transmission spectrum of KELT-9 b with Wendelstein’s FOCES spectrograph

When observing transmission spectra produced by the atmospheres of ultra-hot Jupiters (UHJs), large telescopes are typically the instrument of choice given the very weak signal of the planet’s atmopshere. The aim of the present study is to demonstrate that, for favourable targets, smaller telescopes are fully capable of conducting high-resolution cross-correlation spectroscopy. We apply the cross-

Socioeconomic position indicators and risk of alcohol-related medical conditions : A national cohort study from Sweden

Background AAUlco:hPollecaosencsounmfirpmtitohnatcaollnhteraibduintegsletvoelesxacreersesprmesoernbtiedditcyorarnedctmly:ortality in part through the development of alcohol-related medical conditions (AMCs, including alcoholic cardiomyopathy, hepatitis, cirrhosis, etc.). The current study aimed to clarify the extent to which risk for these outcomes differs as a function of socioeconomic position (

FACTORS ASSOCIATED WITH FATIGUE AMONG PEOPLE WHO HAVE RETURNED TO WORK AFTER STROKE : AN EXPLORATORY STUDY

Objective: To explore the associations between fatigue impact and (a) personal and stroke-related characteristics, (b) functional impairments and (c) work-related factors among individuals who have returned to work after stroke. Design: A cross-sectional exploratory study. Subjects: 87 working stroke survivors. Methods: This study comprises data from a pos-tal survey targeting work ability and per

Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality

The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this process might also cause or contribute to inflammatory disease and lung failure following SARS-CoV-2 infection. To test this hypothesis, we developed a nove

Twenty years on from Developmental Plasticity and Evolution : middle-range theories and how to test them

In Developmental Plasticity and Evolution, Mary-Jane West-Eberhard argued that the developmental mechanisms that enable organisms to respond to their environment are fundamental causes of adaptation and diversification. Twenty years after publication of this book, this once so highly controversial claim appears to have been assimilated by a wealth of studies on ‘plasticity-led’ evolution. However,

Electrocatalytic Hydrogenation of Furfural with Improved Activity and Selectivity at the Surface of Structured Copper Electrodes

Furfural is a pivotal renewable platform molecule obtained from the chemical breakdown of hemicellulose. While it has traditionally been valorized to value-added chemicals through catalytic hydrogenation in biorefineries, its direct electrocatalytic hydrogenation presents attractive advantages. This article describes the significant improvements brought by the structuring of copper cathodes applie

Comparison of Perceptions of Skin Condition, Product Use and Allergen Reactivity Between People with Psoriasis and Controls in the European Dermato-Epidemiology Network (EDEN) Fragrance Study

Psoriasis, a chronic inflammatory skin disease, goes beyond visible symptoms and affects the general well-being of patients. The aim of this study is to understand how patients with psoriasis perceive their skin characteristics and reactivity to allergens. The study population includes 11,283 participants within the European Dermato-Epidemiology Network (EDEN) Fragrance study, covering several Eur

Wear Mechanisms in Cutting Tools for Machining Applications : Interfacial Phenomena, Characterization, and Relation to Performance

Metal cutting technology plays an important role in the automotive and aeronautic sectors, both of whichare important for the Swedish economy. Both make use of traditional grey cast iron and difficult-to-machine materials like titanium alloys and compacted graphite iron. The tools used to machine thesematerials wear at varying rates depending on factors such as contact temperature, pressure, and t

Care of Late-Stage Parkinsonism : Resource Utilization of the Disease in Five European Countries

Background: Parkinson's disease (PD) is a neurodegenerative disease that leads to progressive disability. Cost studies have mainly explored the early stages of the disease, whereas late-stage patients are underrepresented. Objective: The aim is to evaluate the resource utilization and costs of PD management in people with late-stage disease. Methods: The Care of Late-Stage Parkinsonism (CLaSP) stu

A comprehensive exploration of structural and electronic properties of molybdenum clusters

Molybdenum clusters, characterized by their unique structure and intriguing catalytic properties, have gained significant attention in recent years. In several existing studies, density functional theory (DFT) methods have been used to find the lowest energy Mo clusters and explore their electronic and magnetic structure. In all cases, with the exception of a single recent study, where a genetic a

Gene expression in metastatic breast cancer—patterns in primary tumors and metastatic tissue with prognostic potential

Background: Metastatic breast cancer (MBC) is the main cause of breast cancer-related death. The outcome of MBC varies, and there is a lack of biomarkers to aid in prognostication. The primary aim of this study was to evaluate the prognostic value of gene expression (GEX) signatures in the primary tumor (PT) and distant metastasis (DM) for progression-free survival (PFS) and overall survival (OS).