Toward a restorative therapy for Parkinson´s disease. Studies on the functional efficacy of intracerebral fetal cell transplants and GDNF delivery.
Parkinson´s disease is characterized by a progressive degeneration of the nigral dopaminergic system. Treatment of disease symptoms using L-DOPA frequently induces side effects such as L-DOPA-induced dyskinesia. New therapeutic approaches are aimed at preventing neurodegeneration or restoring the dopaminergic system by fetal dopaminergic transplants. In this thesis work, we evaluated the neuroprot