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Contentious colonies: The positional power of imperial peripheries

While structural models of empire have recently re-emerged in the theoretical debates in the field of International Relations, a lack of attention has been paid to peripheral actors therein. This is particularly true for the analysis of the peripheries’ relations with polities outside the imperial structure of which the peripheries are a part. In this article, I build a framework to better underst

Enhancing the {100} grain subdivision in high-purity tantalum sheets by asymmetric cross rolling

Weak subdivision or fragmentation ability of deformed {100} ( // ND, normal direction) grains by traditional unidirectional (symmetric) rolling results in uneven deformation during tantalum (Ta) processing. Thus, a recently developed asymmetric cross rolling (ACR) is adopted in this work to enhance the subdivision of {100} grain in Ta sheets. Electron backscatter diffraction (EBSD), transmission e

Residential electric lighting use during daytime : A field study in Swedish multi-dwelling buildings

This paper evaluates the effect of room function and orientation on daytime electric lighting use in dwellings, and the confounding role of room design aspects. A questionnaire survey was conducted in six multi-dwelling buildings including 75 apartments located in Malmö, Sweden (Latitude: 55.6 °N). Occupants were asked how often they use electric lighting during daylight hours, in three rooms of d

Plasma Homocysteine and Cardiovascular Organ Damage in a Population with a High Prevalence of Risk Factors

PURPOSE: It is unclear whether plasma homocysteine (Hcy) has a direct noxious impact on the cardiovascular (CV) system or whether its association with cardiovascular events (CVEs) is mediated by established risk factors. To explore the role of Hcy in CV impairment, the study evaluated cross-sectional relationships between plasma Hcy and indices of CV organ damage together with the associations of

Efficient production of HPV16 E2 protein from HPV16 late mRNAs spliced from SD880 to SA2709

Human papillomaviruses (HPVs) produce a large number of alternatively spliced mRNAs, including a number of differently spliced mRNAs with the potential to produce E2 protein. To identify the alternatively spliced HPV16 mRNA with the highest ability to produce E2 protein, we have generated E2 cDNA expression plasmids representing the most common, alternatively spliced E2 mRNAs, and assessed their t

A generic PBTK model implemented in the MCRA platform : Predictive performance and uses in risk assessment of chemicals

Physiologically-based toxicokinetic (PBTK) models are important tools for in vitro to in vivo or inter-species extrapolations in health risk assessment of foodborne and non-foodborne chemicals. Here we present a generic PBTK model implemented in the EuroMix toolbox, MCRA 9 and predict internal kinetics of nine chemicals (three endocrine disrupters, three liver steatosis inducers, and three develop

Predictive Factors of Fall-Related Activity Avoidance in People With Parkinson Disease-A Longitudinal Study With a 3-Year Follow-up

BACKGROUND AND PURPOSE: Knowledge of predictive factors can foster the development of preventive approaches. This study examined how prevalence and severity of fall-related activity avoidance evolve over a 3-year period in people with Parkinson disease (PD). A specific aim was to identify predictive factors of fall-related activity avoidance (ie, modified Survey of Activities and Fear of Falling i

Innovations on a shoestring: Consequences for job quality of public service innovations in health and social care

The article examines the innovation-job quality-employment nexus in social and health care in the United Kingdom and Sweden, respectively. Through seven case studies carried out with a common methodological and analytical framework in the two countries, it shows how the constraining factors of fiscal strictures derived from budgetary regimes and chronic labor shortages have two key consequences foThe article examines the innovation-job quality-employment nexus in social and health care in the United Kingdom and Sweden, respectively. Through seven case studies carried out with a common methodological and analytical framework in the two countries, it shows how the constraining factors of fiscal strictures derived from budgetary regimes and chronic labor shortages have two key consequences fo

Effects of Deep Brain Stimulation on Postural Control in Parkinson's Disease

The standard approach to the evaluation of tremor in medical practice is subjective scoring. The objective of this study was to show that signal processing of physiological data, that are known to be altered by tremor in Parkinson's disease (PD), can quantify the postural dynamics and the effects of DBS. We measured postural control and its capacity to adapt to balance perturbations with a force p

Qualitative faecal immunochemical tests (FITs) for diagnosing colorectal cancer in patients with histories of rectal bleeding in primary care: a cohort study

Background Rectal bleeding is considered an alarm symptom for colorectal cancer (CRC) but it is common and mostly caused by benign conditions. Qualitative faecal immunochemical tests (FITs) for occult blood have been used as diagnostic aids for many years in Sweden when CRC is suspected. The study aimed to evaluate the usefulness of FITs requested by primary care physicians for patients with and w

Change in the use of diagnostic tests in the management of lower respiratory tract infections: a register-based study in primary care

Background Differentiating between pneumonia and acute bronchitis is often difficult in primary care. There is no consensus regarding clinical decision rules for pneumonia, and guidelines differ between countries. Use of diagnostic tests and change of management over time is not known. Aim To calculate the proportion of diagnostic tests in the management of lower respiratory tract infections (LRTI

Mitochondrial unfolded protein-related responses across kingdoms : similar problems, different regulators

Mitochondria are key components of eukaryotic cells, so their proper functioning is monitored via different mitochondrial signalling responses. One of these mitochondria-to-nuclear ‘retrograde’ responses to maintain mitochondrial homeostasis is the mitochondrial unfolded protein response (UPRmt), which can be activated by a variety of defects including blocking mitochondrial translation, respirati

Mitochondrial NAD(P)H oxidation pathways and nitrate/ammonium redox balancing in plants

Plant mitochondrial oxidative phosphorylation is characterised by alternative electron transport pathways with different energetic efficiencies, allowing turnover of cellular redox compounds like NAD(P)H. These electron transport chain pathways are profoundly affected by soil nitrogen availability, most commonly as oxidized nitrate (NO3 −) and/or reduced ammonium (NH4 +). The bioenergetic strategi

Gamified physics challenges for teachers and the public

This article describes the development and deployment of Physics Toolbox Play, a gamified component of the Android Physics Toolbox Sensor Suite app, that can introduce young children through adults to fundamental physics principles. The app was used successfully in a variety of contexts, including STEM fairs with primary and secondary students and workshops with undergraduate physics majors and pr

The issues with tissues : the wide range of cell fate separation enables the evolution of multicellularity and cancer

Our understanding of the rises of animal and cancer multicellularity face the same conceptual hurdles: what makes the clade originate and what makes it diversify. Between the events of origination and diversification lies complex tissue organization that gave rise to novel functionality for organisms and, unfortunately, for malignant transformation in cells. Tissue specialization with distinctly s

Numerical studies of gas-liquid Taylor flows in vertical capillaries using CuO/water nanofluids

Heat transfer and pressure drop characteristics of gas-liquid Taylor flows in a mini tube with 1 mm inner tube diameter were investigated numerically using a moving frame of reference method. A CuO/water nanofluid was used as the continuous phase, while nitrogen was adopted as the dispersed phase. The inlet Reynolds number ranged from 250 to 600, and the volume concentration of the CuO particles w

Brain injury after cardiac arrest : from prognostication of comatose patients to rehabilitation

More patients are surviving cardiac arrest than ever before; however, the burden now lies with estimating neurological prognoses in a large number of patients who were initially comatose, in whom the ultimate outcome is unclear. Neurologists, neurointensivists, and clinical neurophysiologists must accurately balance the concern that overly conservative prognostication could leave patients in a sev