The synthesis of a series of novel macrocyclic compounds designed to target blood coagulation Factor XIa is described. The compounds were evaluated for their inhibition of a small set of serine proteases. Several compounds displayed modest activity and good selectivity for Factor XIa. Within the series, a promising lead structure for developing novel macrocyclic inhibitors of thrombin was identifi

This paper describes precision measurements of the transverse momentum pTℓℓ (ℓ= e, μ) and of the angular variable ϕη∗ distributions of Drell–Yan lepton pairs in a mass range of 66–116 GeV. The analysis uses data from 36.1 fb- 1 of proton–proton collisions at a centre-of-mass energy of s=13TeV collected by the ATLAS experiment at the LHC in 2015 and 2016. Measurements in electron-pair and muon-pair

This paper presents a measurement of the production cross-section of a Z boson in association with b-jets, in proton-proton collisions at s = 13 TeV with the ATLAS experiment at the Large Hadron Collider using data corresponding to an integrated luminosity of 35.6 fb−1. Inclusive and differential cross-sections are measured for events containing a Z boson decaying into electrons or muons and produ

The potential role of introgression in evolution has gained increased interest in recent years. Although some fascinating examples have been reported, more information is needed to generalize the importance of hybridization and introgression for adaptive divergence. As limited data exist on haploid dominant species, we analyzed genomes of three subspecies of the liverwort Marchantia polymorpha. We

Background: Magnetic resonance imaging (MRI) serves as a cornerstone in defining stroke phenotype and etiological subtype through examination of ischemic stroke lesion appearance and is therefore an essential tool in linking genetic traits and stroke. Building on baseline MRI examinations from the centralized and structured radiological assessments of ischemic stroke patients in the Stroke Genetic

Background: The frequent emergence of the re-positive patients with COVID-19 is a potential threat worldwide. This study aimed to describe data from admission to follow-up for patients with COVID-19 and analyze the possible causes for re-positive nucleic acid tests to provide more scientific basis for reducing the numbers of re-positive patients after discharge. Methods: We retrospectively recorde

The fungal metabolite galiellalactone (1) was, as its acetate 4, discovered to undergo a substitution reaction with cysteine derivatives. By studying the reaction mechanism and the intermediates formed, and in an effort to expand the chemical diversity of the galiellalactonoids, a mild and general method of preparing ether, thioether, and amine analogues of galiellalactone was developed. The react

We are reinvestigating the hyperfine structure of sodium using a fully relativistic multiconfiguration approach. In the fully relativistic approach, the computational strategy somewhat differs from the original nonrelativistic counterpart used by P. Jönsson, Phys. Rev. A 53, 4021 (1996)PLRAAN1050-294710.1103/PhysRevA.53.4021. Numerical instabilities force us to use a layer-by-layer approach that h

Recent surveys have revealed that protoplanetary discs typically have dust masses that appear to be insufficient to account for the high occurrence rate of exoplanet systems. We demonstrate that this observed dust depletion is consistent with the radial drift of pebbles. Using a Monte Carlo method we simulate the evolution of a cluster of protoplanetary discs using a 1D numerical method to viscous

Context. Single-binary scattering may lead to an exchange where the single object captures a component of the binary, forming a new binary. This has been well studied in encounters between a star-planet pair and a single star. Aims. Here we explore the application of the exchange mechanism to a planet-satellite pair and another planet in the gravitational potential of a central star. As a case stu

The interest in plant-based products is growing in Western countries, mostly due to health and environmental issues that arise from the consumption and production of animal-based food products. Many vegan products today are made from soy, but drawbacks include the challenges of cultivating soy in colder climates such as northern Europe. Therefore, the present study investigates whether industrial

Thoughtful use of simplifying assumptions is crucial to make systems biology models tractable while still representative of the underlying biology. A useful simplification can elucidate the core dynamics of a system. A poorly chosen assumption can, however, either render a model too complicated for making conclusions or it can prevent an otherwise accurate model from describing experimentally obse

gregor.traven@astro.lu.se.

In order to produce a more efficient design of a compact turbine driving a cryogenic engine turbo-pump for a satellite delivering rocket, a new supersonic loss model is proposed. The new model was constructed based on high-quality published data, composed of Schlieren photographs and experimental measurements, that combined provided a unique insight into the mechanisms driving supersonic losses. U

Uncertainty analysis is important for wastewater treatment plant (WWTP) model applications. An important aspect of uncertainty analysis is the identification and proper quantification of sources of uncertainty. In this contribution, a methodology to identify an ensemble of behavioural model representations (combinations of input data, model structure and parameter values) is presented and evaluate

Changes in dilution of wastewater to a treatment plant due to infiltration or surface runoff can have a great impact on treatment process performance. This paper presents a model-based approach in which realistic influent scenarios are generated and used as inputs to a dynamic plant-wide process model of the wastewater treatment plant. The simulated operation is subsequently evaluated using life-c

Neuroblastoma is the most common paediatric cancer type. Patients diagnosed with high-risk neuroblastoma have poor prognosis and occasionally tumours relapse. As a result, novel treatment strategies are needed for relapse and refractory neuroblastoma patients. Here, we found that high expression of Mps1 kinase (mitotic kinase Monopolar Spindle 1) was associated with relapse-free neuroblastoma pati

Most models of sedimentation contain the nonlinear hindered-settling flux function. If one assumes ideal conditions and no compression, then there exist several theoretically possible ways of identifying a large portion of the flux function from only one experiment by means of formulas derived from the theory of solutions of partial differential equations. Previously used identification methods an

Flotation is a separation process where particles or droplets are removed from a suspension with the aid of floating gas bubbles. Applications include dissolved air flotation (DAF) in industrial wastewater treatment and column froth flotation (CFF) in wastewater treatment and mineral processing. One-dimensional models of flotation have been limited to steady-state situations for half a century by