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Betahistine prevents development of endolymphatic hydrops in a mouse model of insulin resistance and diabetes

BACKGROUND: Diabetes is associated with inner ear dysfunction. Furthermore, C57BL/6J mice fed high fat diet (HFD), a model for insulin resistance and diabetes, develop endolymphatic hydrops (EH).AIM: Evaluate if betahistine, spironolactone (aldosterone antagonist) and empagliflozin (sodium -glucose cotransporter2 inhibitor) can prevent EH induced by HFD and explore potential mechanisms.METHODS: C5

An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers

Background: Cancer immunity is based on the interaction of a multitude of cells in the spatial context of the tumour tissue. Clinically relevant immune signatures are therefore anticipated to fundamentally improve the accuracy in predicting disease progression. Methods: Through a multiplex in situ analysis we evaluated 15 immune cell classes in 1481 tumour samples. Single-cell and bulk RNAseq data

Essays in Education Economics

This dissertation consists of three self-contained papers in the economics of education. The first chapter examines the effect of more informative feedback on student performance. Using a difference-in-discontinuity research design and data on the population of Swedish school children, we exploit a reform which introduced a more granular grading scale and thus provided students with more informati

Global Legitimacy Crises : Decline and Revival in Multilateral Governance

Presents new conceptualization of legitimacy crises in global governanceOffers new theoretical ideas on legitimacy crises as activation that can yield positive as well as negative consequencesProvides a comparative assessment of legitimacy crises and their consequences in 32 international organizations and across three decadesDevelops in-depth insights on the legitimacy crises of the WTO and the U

Generation of two compound heterozygous HGSNAT-mutated lines from healthy induced pluripotent stem cells using CRISPR/Cas9 to model Sanfilippo C syndrome

Sanfilippo C syndrome (Mucopolysaccharidosis IIIC) is a rare lysosomal storage disorder caused by mutations in the HGSNAT gene. It is characterized by a progressive and severe neurodegeneration, for which there is no treatment available. Here, we report the generation of two HGSNAT-mutated cell lines from a healthy human induced pluripotent stem cell (hiPSC) line using CRISPR/Cas9 editing. These n

Transcription Factor-Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth In Vitro and In Vivo

Direct cellular reprogramming has recently gained attention of cancer researchers for the possibility to convert undifferentiated cancer cells into more differentiated, postmitotic cell types. While a few studies have attempted reprogramming of glioblastoma (GBM) cells toward a neuronal fate, this approach has not yet been used to induce differentiation into other lineages and in vivo data on redu

Spectroscopy along flerovium decay chains. II. Fine structure in odd-A 289Fl

Fifteen correlated α-decay chains starting from the odd-A superheavy nucleus 289Fl were observed following the fusion-evaporation reaction 48Ca+244Pu. The results call for at least two parallel α-decay sequences starting from at least two different states of 289Fl. This implies that close-lying levels in nuclei along these chains have quite different spin-parity assignments. Further, observed α-el

Spectroscopy along flerovium decay chains. III. Details on experiment, analysis, 282Cn, and spontaneous fission branches

Flerovium isotopes (element Z = 114) were produced in the fusion-evaporation reactions 48Ca+242,244Pu and studied with an upgraded TASISpec decay station placed in the focal plane of the gas-filled separator TASCA at the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. Twenty-nine flerovium decay chains were identified by means of correlated implantation, α decay, and spontaneo

SPACAP Working Paper No. 1 : How do Swedish Public Agencies understand, approach and operationalize Capacity Development work abroad?

Capacity development (CapDev) support through various Swedish public agencies (SPA) to their sister authorities in low- and middle-income countries has been a salient feature of Sweden’s institutional development cooperation since the1980s. Despite constituting a small percentage of Swedish aid, the scale and scope of SPAs engagement in CapDev work abroad deserves more attention than currently bei

SPACAP Working Paper No. 2 : How do Swedish Public Agencies understand, approach and operationalize Capacity Development work abroad?

This summary addresses the overall results of the Swedish Public Agencies’ Capacity Development (SPACAP) study that started in December 2018, whereas the main body of this second, and final, Working Paper mainly focusses on the way forward. SPACAP is a Sida funded one-year study project conducted byLund University in collaboration with the SPAs’ Network for Learning (N4L), which aims at providing

Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes : The TEDDY Study

OBJECTIVE: To distinguish among predictors of seroconversion, progression to multiple autoantibodies and from multiple autoantibodies to type 1 diabetes in young children.RESEARCH DESIGN AND METHODS: Genetically high-risk newborns (n = 8,502) were followed for a median of 11.2 years (interquartile range 9.3-12.6); 835 (9.8%) developed islet autoantibodies and 283 (3.3%) were diagnosed with type 1

A climate risk analysis of Earth's forests in the 21st century

Earth's forests harbor extensive biodiversity and are currently a major carbon sink. Forest conservation and restoration can help mitigate climate change; however, climate change could fundamentally imperil forests in many regions and undermine their ability to provide such mitigation. The extent of climate risks facing forests has not been synthesized globally nor have different approaches to qua

Climate Change Risks to Global Forest Health : Emergence of Unexpected Events of Elevated Tree Mortality Worldwide

Recent observations of elevated tree mortality following climate extremes, like heat and drought, raise concerns about climate change risks to global forest health. We currently lack both sufficient data and understanding to identify whether these observations represent a global trend toward increasing tree mortality. Here, we document events of sudden and unexpected elevated tree mortality follow

Enhanced Effective Aperture Distribution Function for Characterizing Large-Scale Antenna Arrays

Accurate characterization of large-scale antenna arrays is growing in importance and complexity for the fifth-generation (5G) and beyond systems, as they feature more antenna elements and require increased overall performance. The full 3D patterns of all antenna elements in the array need to be characterized because they are in general different due to construction inaccuracy, coupling, antenna ar

Toward 6G with Terahertz Communications: Understanding the Propagation Channels

This article aims at providing insights for a comprehensive understanding of THz propagation channels. Specifically, we discuss essential THz channel characteristics to be well understood for the success of THz communications. The methodology of establishing realistic and 6G-compliant THz channel models based on measurements is then elaborated on, followed by a discussion on existing THz channel m

Disease Features and Gastrointestinal Microbial Composition in Patients with Systemic Sclerosis from Two Independent Cohorts

Objective: The study objective was to examine alterations in gastrointestinal (GI) microbial composition in patients with systemic sclerosis (SSc) and to investigate the relationship between SSc features and GI microbiota using two independent, international cohorts. Methods: Prospective patients with SSc from Lund University (LU), Sweden, from the University of California, Los Angeles (UCLA), Uni