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Current theories of the glymphatic system (GS) hypothesize that it relies on cerebrospinal fluid (CSF) circulation to disseminate growth factors and remove metabolic waste from the brain with increased CSF production and circulation during sleep; thereby, linking sleep disturbance with elements of CSF circulation and GS exchange. However, our growing knowledge of the relations between sleep, CSF,

When considered separately from cardiovascular disease, stroke is the third leading cause of death in the U.S. and is the leading cause of long-term disability in adults. New approaches that can be offered to the majority of ischemic stroke patients, can be continued throughout post-stroke care, can limit stroke severity, and can complement or even enhance rehabilitation, would transform ischemic

We investigate the possibility of erosion of planetesimals in a protoplanetary disk. We use theory and direct numerical simulations (lattice Boltzmann method) to calculate the erosion of large - much larger than the mean-free path of gas molecules - bodies of different shapes in flows. We find that erosion follows a universal power law in time, at intermediate times, independent of the Reynolds nu

The increased urbanization and human population growth of the recent decades have resulted in the loss of urban green spaces. One policy used to prevent the loss of urban green space is ecological compensation. Ecological compensation is the final step in the mitigation hierarchy; compensation measures should thus be a last resort after all opportunities to implement the earlier steps of the hiera

Ever higher demands on the sealing of rock around underground structures drive the development of cement-based grouts. The results of the previous study demonstrated that it is possible to mill cement to approximately 20 to 25 µm and use it to seal fracture aperture down to approximately 70 µm. Further milling deteriorates the penetrability of the grouts due to the flocculation of the fine particl

The neocortex has a globally encompassing network structure, which for each given input constrains the possible combinations of neuronal activations across it. Hence, its network contains solutions. But in addition, the cortex has an ever-changing multidimensional internal state, causing each given input to result in a wide range of specific neuronal activations. Here we use intracellular recordin

The electromagnetic character of the ΔI=1 transitions connecting the 1- to 0-phonon and the 2- to 1-phonon wobbling bands should be dominated by an E2 component, due to the collective motion of the entire nuclear charge. In the present work it is shown, based on combined angular correlation and linear polarization measurements, that the mixing ratios of all analyzed connecting transitions between

For many years, blood-based biomarkers for Alzheimer's disease seemed unattainable, but recent results have shown that they could become a reality. Convincing data generated with new high-sensitivity assays have emerged with remarkable consistency across different cohorts, but also independent of the precise analytical method used. Concentrations in blood of amyloid and phosphorylated tau proteins

Growing evidence supports the importance of lifestyle and environmental exposures— collectively referred to as the ‘exposome’—for ensuring immune health. In this narrative review, we summarize and discuss the effects of the different exposome components (physical activity, body weight management, diet, sun exposure, stress, sleep and circadian rhythms, pollution, smoking, and gut microbiome) on im

To explore the availability and accessibility of medically assisted reproduction (MAR) for people living with HIV in Europe, including the feasibility of cross-border care. Methods: We used a polymorphous engagement approach, primarily based on digital and email-based interviews with representatives of national HIV organizations, clinical researchers (infectious disease and/or infertility speciali

The concept of digital discretion has been defined as information and communication technology (ICT) influencing or replacing the professional judgment of civil servants. Studies within digital discretion has mainly taken a civil servants perspective focusing on how ICT can constrain or enable discretionary practices (Bovens and Zouridis 2002; Wenger and Wilkis 2009; Wihlborg et al. 2016) have inv

I have analyzed the coverage of the 30th anniversary of the Roundtable Agreement and June elections in Polish news-papers of all political hues. Additionally, I scrutinized several official speeches held in connection with the commemorations. The goal of my inquiry has been to examine the uses of memory of 1989 in Polish politics of 2019 and highlight the strategic choices and constraints faced by

The memory of the Holocaust has become one of the most salient and fully-fledged transnational collective memories traveling around the world. Most of the scholarship tracing the transnational flows of Holocaust memory representations has focussed on literature, films, and other media products. This lecture, however, instead foregrounds the research on memory practices in specific geographic locat

The article discusses the nationalist right-wing memory discourses in contemporary East Central and Southeastern Europe. It points out their main features such as: nationalization, re-nationalization, securitization, victimization, and weaponization of the Communist and post-Communist past. The focus is to explain the historical and cultural roots of these memory discourses, which are of vital imp

We tested concentration-dependence of selected gene transcripts (cat, gst, hsp70, hsp90, mt and sod) for evaluation as biomarkers of chemical stress. Contrary to the common approach of factorial designs and few exposure concentrations, we used regression across a high-resolution concentration series. Specifically, freshwater mussels (Anodonta anatina) were acutely (96 h) exposed to Cu (13 nominal

Context. Next to H and He, carbon is, together with oxygen, the most abundant element in the Universe and widely used when modelling the formation and evolution of galaxies and their stellar populations. For the Milky Way bulge, there are currently essentially no measurements of carbon in un-evolved stars, hampering our abilities to properly compare Galactic chemical evolution models to observatio

During solar storms, the Sun expels large amounts of energetic particles (SEP) that can react with the Earth’s atmospheric constituents and produce cosmogenic radionuclides such as 14C, 10Be and 36Cl. Here we present 10Be and 36Cl data measured in ice cores from Greenland and Antarctica. The data consistently show one of the largest 10Be and 36Cl production peaks detected so far, most likely produ

This paper presents experimental studies of the structures and burning velocities of premixed ammonia/air jet flames at high Karlovitz (Ka) number conditions. Simultaneous planar laser-induced fluorescence (PLIF) imaging of imidogen (NH) and hydroxyl (OH) radicals was performed to investigate the local flame structure and Laser Doppler Anemometry (LDA) measurements were employed for extracting com