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Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function
TRPV2 is a ligand-operated temperature sensor with poorly defined pharmacology. Here, we combine calcium imaging and patch-clamp electrophysiology with cryo-electron microscopy (cryo-EM) to explore how TRPV2 activity is modulated by the phytocannabinoid Δ9-tetrahydrocannabiorcol (C16) and by probenecid. C16 and probenecid act in concert to stimulate TRPV2 responses including histamine release from
Making space in the city for diverse life worlds and temporalities : An explorative investigation of the affordance and territoriality of urban cemeteries
The urban cemetery is a built green environment that is both a place of death, belonging to the bereaved and their rituals of care and remembrance, and a recreational space, where people rest, walk their dog, jog, reflect in silence, or just pass through. Urban cemeteries and urban parks share some features and uses in that respect, but they also have very different meanings and functions. The resThe urban cemetery is a built green environment that is both a place of death, belonging to the bereaved and their rituals of care and remembrance, and a recreational space, where people rest, walk their dog, jog, reflect in silence, or just pass through. Urban cemeteries and urban parks share some features and uses in that respect, but they also have very different meanings and functions. The res
Law and expulsions insidethe Swedish welfare state. : The ‘craftwork of illegalisation’ and the management of undeportable deportees.
The article presents a legal ethnographic study of the contradiction between the rhetoric of return, stressing that rejected asylum seekers should leave the country, and the reality of legally stranded migrants, in a Swedish context. Through an in-depth analysis of three individual asylum case files, the study reveals how a situation comes about where rejected asylum seekers end up as legally stra
Interfacial profile of axial nanowire heterostructures in the nucleation limited regime
Heterostructured nanowires exhibit unique physical and electronic properties and are most commonly grown by the vapor-liquid-solid mechanism. Some of these properties are related to the interfacial abruptness of the heterointerface which makes its understanding and control particularly important for further development. In this regard, we present a model based on mass balance of atoms in the catal
Second-generation Elecsys cerebrospinal fluid immunoassays aid diagnosis of early Alzheimer's disease
Timely diagnosis of Alzheimer's disease (AD) is critical for appropriate treatment/patient management. Cerebrospinal fluid (CSF) biomarker analysis is often used to aid diagnosis. We assessed analytical performance of second-generation (Gen II) Elecsys® CSF immunoassays (Roche Diagnostics International Ltd), and adjusted existing cut-offs, to evaluate their potential utility in clinical routine. A
Re: Rakesh Heer, Rebecca Lewis, Thenmalar Vadiveloo, et al. A Randomized Trial of PHOTOdynamic Surgery in Non-muscle-invasive Bladder Cancer. NEJM Evid. In press. https://doi.org/10.1056/EVIDoa2200092
Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling
Patient-derived cells hold great promise for precision medicine approaches in human health. Human dermal fibroblasts have been a major source of cells for reprogramming and differentiating into specific cell types for disease modeling. Postmortem human dura mater has been suggested as a primary source of fibroblasts for in vitro modeling of neurodegenerative diseases. Although fibroblast-like cell
Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease continuum
BACKGROUND: Alzheimer's disease is characterized by an abnormal increase of phosphorylated tau (pTau) species in the CSF. It has been suggested that emergence of different pTau forms may parallel disease progression. Therefore, targeting multiple specific pTau forms may allow for a deeper understanding of disease evolution and underlying pathophysiology. Current immunoassays measure pTau epitopes
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To organize a conference under ever-changing conditions - Editorial to the special issue from the TRACE 2021 virtual meeting
Blame as a sentiment
The nature of blame is not to be identified solely with a judgment, or an overt act, or an angry emotion. Instead, blame should be identified with a sentiment: more specifically, a multi-track disposition that manifests itself in various different emotions, thoughts or actions in a range of different circumstances. This paper aims to argue for these two claims. I start by arguing that blame is not
Asking About “Prostitution”, “Sex Work” and “Transactional Sex” : Question Wording and Attitudes Toward Trading Sexual Services
This study explored the impact of question wording on attitudes toward trading sexual services. There are no previous research agendas investigating how views on the trade in sex are susceptible to question word choice. We utilized an original survey to assess how three different concepts used to represent the exchange of sexual services impact on the reported level of acceptability among responde
Konstens charkuteribiträden
Photophysical Integrity of the Iron(III) Scorpionate Framework in Iron(III)-NHC Complexes with Long-Lived 2LMCT Excited States
Fe(III) complexes with N-heterocyclic carbene (NHC) ligands belong to the rare examples of Earth-abundant transition metal complexes with long-lived luminescent charge-transfer excited states that enable applications as photosensitizers for charge separation reactions. We report three new hexa-NHC complexes of this class: [Fe(brphtmeimb)2]PF6(brphtmeimb = [(4-bromophenyl)tris(3-methylimidazol-2-yl
External Validation of the Ovarian-Adnexal Reporting and Data System (O-RADS) Lexicon and the International Ovarian Tumor Analysis 2-Step Strategy to Stratify Ovarian Tumors Into O-RADS Risk Groups
IMPORTANCE: Correct diagnosis of ovarian cancer results in better prognosis. Adnexal lesions can be stratified into the Ovarian-Adnexal Reporting and Data System (O-RADS) risk of malignancy categories with either the O-RADS lexicon, proposed by the American College of Radiology, or the International Ovarian Tumor Analysis (IOTA) 2-step strategy.OBJECTIVE: To investigate the diagnostic performance
Teacher-to-Classroom Assignment and Student Achievement
We study the effects of counterfactual teacher-to-classroom assignments on average student achievement in U.S. elementary and middle schools. We use the Measures of Effective Teaching (MET) experiment to semiparametrically identify the average reallocation effects (AREs) of such assignments. Our identification strategy exploits the random assignment of teachers to classrooms in MET schools. To acc
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Interactive Interventions can Improve Hand Hygiene and Aseptic Techniques During Perioperative Care – Experience From the “Safe Hands” Project
Purpose: This paper evaluates a theory-driven, interactive hand hygiene (HH) intervention, the Safe Hands project, based on theories of organizational learning and culture including leadership support, dialogue and co-creation. Design: This prospective quasi-experimental study used unobtrusive overt observations to evaluate adherence to HH recommendations after implementing an infection-prevention
The prototyping of a high-resolution neutron activation analysis system - Based on a Pelletron accelerator and fast pneumatic sample-transport
A new neutron activation analysis system is currently being designed at Lund University. The design incorporates a compact accelerator driven neutron source, based on a 3 MV Pelletron accelerator and a pneumatic sample conveyor to transport samples from the neutron source to a measurement station consisting of an array of high-purity Ge γ-ray detectors. A prototype for this new station is currentl