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Tongue retraction is not so useful after all

This article reports model experiments where vocal tract profiles of high and mid unrounded front and high rounded back vowels were systematically modified to simulate small constriction shifts along the hard or soft palate, in order to test A. M. Bell's century-old proposal that small shifts of tongue arch fronting or retraction would yield audible shifts of vowel timbre. Such differences were cl

Isotope dependent predissociation in the C-1 Sigma(+) ,v=0 and v=1 states of CO

Rotationally resolved spectral lines in the C-X(1,0) band of carbon monoxide are investigated under high resolution using a coherent vacuum ultraviolet laser source, continuously tunable near 107 nm. Transition frequencies are determined by calibrating against a reference standard of iodine lines, recorded with saturation spectroscopy in the visible range, yielding an absolute accuracy of 0.003 cm

A literature review of the regional implementation of the central Swedish government's health care reforms on choice and privatization.

The introduction in 2010 of the Freedom of Choice Act represents one of the most far-reaching reforms of the Swedish health system. While it is mandatory for the regional counties to introduce choice plans for primary care it is voluntary for ambulatory specialist services. The voluntary nature of the regulations for the latter types of care generates a potential gap between the central government

Runsten på resa : Lundagårdsstenen från vikingatid till nutid

The article traces the Lundagård rune-stone on its road in Lund – from its origin as a part of a Viking Age monument probably at Helgonabacken, its reuse at the All Saints monastery, where it was rediscovered in 1682, to the Lundagård park in the 1740s, its reuse in a memorial in the old Botanical Garden in 1868 to its location in the university library since 1957. The movements are perceived as aThe article traces the Lundagård rune-stone on its road in Lund – from its origin as a part of a Viking Age monument probably at Helgonabacken, its reuse at the All Saints monastery, where it was rediscovered in 1682, to the park Lundagård in the 1740s, its reuse in a memorial in the old Botanical Garden in 1868 to its location in the university library since 1957. The movements are perceived as a

En hjälte på djupt vatten

Kulturartikel om arvet efte oceanografen och naturfilmaren Jacques-Yves Cousteau med anledning av en rad böcker och blurayutgåvor om och av honom.

Secretion and Dipeptidyl Peptidase-4-Mediated Metabolism of Incretin Hormones after a Mixed Meal or Glucose Ingestion in Obese Compared to Lean, Nondiabetic Men.

Context: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are cleaved by dipeptidyl peptidase-4 (DPP-4); plasma activity of DPP-4 may be increased in obesity. The impact of this increase on incretin hormone secretion and metabolism is not known. Objective: The aim of the study was to assess incretin hormone secretion and degradation in lean and obese nondiabet

Dendritic EGFP-STIM1 activation after type I metabotropic glutamate and muscarinic acetylcholine receptor stimulation in hippocampal neuron.

Several signaling pathways in neurons engage the endoplasmic reticulum (ER) calcium store by triggering calcium release. After release, ER calcium levels must be restored. In many non-neuronal cell types, this is mediated by store-operated calcium entry (SOCE), a cellular homeostatic mechanism that activates specialized store-operated calcium channels (SOC). Although much evidence supports the exi

Increase in percent free prostate-specific antigen in men with chronic kidney disease.

BACKGROUND: Prostate-specific antigen (PSA) occurs in different molecular forms in serum: free PSA (fPSA) and complexed PSA (cPSA), the sum of which corresponds to total PSA (tPSA). In addition to tPSA, percent fPSA is widely used in the detection of prostate cancer. Free PSA, approximately 28 kDa, is eliminated by glomerular filtration. Previous data showed that men with end-stage renal dysfuncti

ADP receptor P2Y(13) induce apoptosis in pancreatic beta-cells.

Pancreatic beta-cell loss represents a key factor in the pathogenesis of diabetes. Since the influence of purinergic signaling in beta-cell apoptosis has not been much investigated, we examined the role of the ADP receptor P2Y(13) using the pancreatic insulinoma-cell line MIN6c4 as a model system. Real time-PCR revealed high expression of the ADP receptors P2Y(1) and P2Y(13). Adding the ADP analog

Vasoactive Peptides with Angiogenesis-Regulating Activity Predict Cancer Risk in Males.

BACKGROUND: Tumor development requires angiogenesis, and antiangiogenesis has been introduced in the treatment of cancer patients; however, how the cardiovascular phenotype correlates with cancer risk remains ill-defined. Here, we hypothesized that vasoactive peptides previously implicated in angiogenesis regulation predict long-term cancer risk.METHODS: We measured midregional proatrial natriuret