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Battling Bacterial Biofilm - antibiotic regimens targeting Grampositive pathogens in biofilm

Popular Abstract in Swedish Vår hud och våra slemhinnor är ständigt koloniserade med bakterier som lever i fredligt samspel med vår organism. Dessa bakterier tillhör vår normalflora och kan indelas i kommensaler respektive opportunistiska bakterier. Kommensalerna gagnar värden på olika sätt och orsakar inte sjukdom, till skillnad från opportunisterna som under vissa betingelser kan orsaka infektioAbstractBacteria in most environments encase themselves in a hydrated matrix of polysaccharide and protein, forming organized communities called biofilms. In the biofilm bacteria are protected against hostile environments. Biofilms are important clinically because of their persistence despite host defence and their recalcitrance to antimicrobials. This thesis presents three main findings: (i) biof

Shortest Paths with Curvature and Torsion

This paper describes a method of finding thin, elongated structures in images and volumes. We use shortest paths to minimize very general functionals of higher-order curve properties, such as curvature and torsion. Our globally optimal method uses line graphs and its runtime is polynomial in the size of the discretization, often in the order of seconds on a single computer. To our knowledge, we ar

Noise Convolution Models: Fluids in Stochastic Motion, Non-Gaussian Tempo-Spatial Fields, and a Notion of Tilting

The primary topic of this thesis is a class of tempo-spatial models which are rather flexible in a distributional sense. They prove quite successful in modeling (temporal) dependence structures and go beyond the limitation of Gaussian models, thus allowing for heavy tails and skewness. By generalizing the construction of the above class of models, it is possible to ‘control’ some random geometric

Novel gene targets detected by genomic profiling in a consecutive series of 126 adults with acute lymphoblastic leukemia

In contrast to acute lymphoblastic leukemia in children, adult cases of this disease are associated with a very poor prognosis. In order to ascertain whether the frequencies and patterns of submicroscopic changes, identifiable with single nucleotide polymorphism array analysis, differ between childhood and adult acute lymphoblastic leukemia, we performed single nucleotide polymorphism array analys

Large herbivore grazing affects the vegetation structure and greenhouse gas balance in a high arctic mire

Herbivory is an important part of most ecosystems and affects the ecosystems' carbon balance both directly and indirectly. Little is known about herbivory and its impact on the carbon balance in high arctic mire ecosystems. We hypothesized that trampling and grazing by large herbivores influences the vegetation density and composition and thereby also the carbon balance. In 2010, we established fe

Multitaper Wigner distribution with pre-determined doppler-lag bandwdith and sidelobe suppression

Multi taper spectrogram decomposition of the time-lag kernel of a time-frequency distribution might result in computationally efficient calculations if the number of multi tapers to be considered in the spectrogram are small. In this paper, penalty functions are designed and used in the computation of multi tapers corresponding to the Wigner distribution time-lag kernel. The resulting multi taper

Compton scattering from deuterium and the polarizabilities of the neutron

A new program of Compton scattering on deuterium is under way at the tagged-photon facility at MAX-Lab in Lund, Sweden. We will measure differential cross sections between 60A degrees and 150A degrees over the photon energy range 60-115 MeV in 5 MeV steps, with the ultimate goal of obtaining new precision information on the electric and magnetic polarizabilities of the neutron.

Population fluctuations and synchrony of grassland butterflies in relation to species traits.

Population fluctuations and synchrony influence population persistence; species with larger fluctuations and more synchronised population fluctuations face higher extinction risks. Here, we analyse the effect of diet specialisation, mobility, length of the flight period, and distance to the northern edge of the species' distribution in relation to between-year population fluctuations and synchrony

Substance use in adolescents and young adults: Interactions of drugs of abuse and the role of parents and peers in early onset of substance use

Background: Misuse of substances is a major contributor to disability and mortality worldwide. The use of tobacco, alcohol, and illegal drugs in adolescence and young adulthood are well-known risk factors for subsequent substance-related harms. A better understanding of adolescent and young adult substance use behaviors and their correlates might help develop new prevention programs. This thesis a

Search for diphoton events with large missing transverse momentum in 7 TeV proton-proton collision data with the ATLAS detector

A search for diphoton events with large missing transverse momentum has been performed using proton-proton collision data at is root s = 7 TeV recorded with the ATLAS detector, corresponding to an integrated luminosity of 4.8 fb(-1). No excess of events was observed above the Standard Model prediction and model-dependent 95% confidence level exclusion limits are set. In the context of a generalise

Tunneling spectroscopy of superconducting nanospheres

Energy spectra of superconducting nanospheres observed via tunneling spectroscopy are theoretically discussed. In the energy gap we find small peaks which correspond to the two-particle dynamics beyond the mean-field BCS approximation. These peaks promise to be a sensitive test of theories of superconductivity as their number and positions depend on the approximation used.

Geographical and temporal flexibility in the response to crosswinds by migrating raptors.

Wind and ocean currents may potentially have important effects on travelling animals, as an animal which does not respond to lateral flow will be drifted from its intended direction of movement. By analysing daily movements of migrating ospreys Pandion haliaetus and marsh harriers Circus aeruginosus, as recorded by satellite telemetry, in relation to global wind data, we showed that these raptors

Health Alliance for Prudent Prescribing, Yield and Use of Antimicrobial Drugs in the Treatment of Respiratory Tract Infections (HAPPY AUDIT)

Background: Excessive and inappropriate use of antibiotics is considered to be the most important reason for development of bacterial resistance to antibiotics. As antibiotic resistance may spread across borders, high prevalence countries may serve as a source of bacterial resistance for countries with a low prevalence. Therefore, bacterial resistance is an important issue with a potential serious

Dynamics of charge separation in the excited-state chemistry of protochlorophyllide

In this study the excited-state dynamics of protochlorophyllide a (PChlide), the substrate of the enzyme protochlorophyllide oxidoreductase, was examined by means of time-resolved absorption anisotropy and magic-angle measurements. The solvent polarity dependent anisotropy data provide strong evidence for the existence of an excited-state with charge-transfer character. A solvent dependency is als