Despite growing interest of Open Innovation (OI) in Software Engineering (SE), little is known about what triggers software organizations to adopt it and how this affects SE practices. OI can be realized in numerous of ways, including Open Source Software (OSS) involvement. Outcomes from OI are not restricted to product innovation but also include process innovation, e.g. improved SE practices and

This study investigates interaction in dialogues between children with language impairment (LI) and peers of different ages and at two different times, taking into account the language skills of the children with LI. The hypotheses tested were that dialogues between more mature children are more coherent and that the degree of language problems of the child with LI is not directly associated with

Den ständiga jakten på de allra senaste trenderna är en tidskrävande och intensiv aktivitet bland konsumenter som vill hålla sig uppdaterade inom det snabba modet. Fast fashion konsumtion ger möjligheter för konsumenter att hitta och prova nya trender, skapa de senaste klädkombinationerna, och leka med olika stilar. Att hänga med i tempot av nya trender är populärt bland fast fashion konsumenter, Consumers are dedicated and committed to figuring out ways and creating investigative activities to keep up with a fast-moving retail market. These ways and activities are in this study seen as learning activities, which focus on getting to know the marketplace. The context is the fast fashion marketplace in which offerings are desirable because of their limited availability. This temporary charac

The role of lymphadenectomy in the management of early endometrial cancer remains controversial. In the recent ESMO-ESGO-ESTRO guidelines, lymphadenectomy is recommended for patients with endometrioid adenocarcinoma Grade 3 with deep myometrial invasion, but complete agreement was not achieved. In Sweden, DNA aneuploidy has been included as a high-risk factor. The aim of our study was to evaluate

Objective: To investigate whether the Multi-Biomarker Disease Activity (MBDA) score predicts optimal add-on treatment in patients with early rheumatoid arthritis (RA) who were inadequate responders to MTX (MTX-IRs). Methods: We analyzed data from 157 MTX-IRs (with a Disease Activity Score using the erythrocyte sedimentation rate [DAS28-ESR] >3.2) from the Swedish Pharmacotherapy (SWEFOT) trial who

In this study, a new strategy for fault detection and isolation is presented. This strategy is based on the design of a Lüneburg observer which is implemented via pole placement using linear matrix inequalities. Two residuals are formulated based on the state estimation error in order to be utilized in detecting and isolating faults happened on the system. Fault detection problem solves by change

Many natural language processing systems rely on machine learning models that are trained on large amounts of manually annotated text data. The lack of sufficient amounts of annotated data is, however, a common obstacle for such systems, since manual annotation of text is often expensive and time-consuming. The aim of “PAL", a tool for Pre-annotation and Active Learning” is to provide a ready-made

BACKGROUND: Depression affects over 120 million individuals of all ages and is the leading cause of disability worldwide. The lack of objective diagnostic criteria, together with the heterogeneity of the depressive disorder itself, makes it challenging to develop effective therapies. The accumulation of preclinical data over the past 20 years derived from a multitude of models using many divergent

Voltage-gated sodium channels (Nav1.1-Nav1.9) are responsible for the initiation and propagation of action potentials in neurons, controlling firing patterns, synaptic transmission and plasticity of the brain circuit. Yet, it is the protein-protein interactions of the macromolecular complex that exert diverse modulatory actions on the channel, dictating its ultimate functional outcome. Despite the

The interpretation of phosphoproteomics data sets is crucial for generating hypotheses that guide therapeutic solutions, yet not many techniques have been applied to this type of analysis. This paper intends to give an overview about the two main standard techniques that can be applied to the analysis of these large scale data sets. These are data-driven or exploratory techniques based on a statis

The heterodimer HIF-1α (hypoxia inducible factor)/HIF-β (also known as ARNT-aryl hydrocarbon nuclear translocator) is a key mediator of cellular response to hypoxia. The interaction between these monomer units can be modified by the action of small molecules in the binding interface between their C-terminal heterodimerization (PasB) domains. Taking advantage of the presence of several cysteine res

Background: Electrodermal reactivity has been successfully used as indicator of interest, curiosity as well as depressive states. The measured reactivity depends on the quantity of sweat secreted by those eccrine sweat glands that are located in the hypodermis of palmar and plantar regions. Electrodermal hyporeactive individuals are those who show an unusual rapid habituation to identical non-sign

Objectives: We wanted to investigate the effects of postoperative pulmonary hypertension (PHpostop: mean pulmonary artery pressure [MPAP] ≥ 25 mmHg), diastolic pressure gradient (DPG), pulmonary vascular resistance (PVR), and repeated hemodynamic measurements on long-term survival after heart transplantation (HT). Design: Eighty-nine patients who underwent HT at Skåne University Hospital in Lund i