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Methodological tools for studies of the cytostatic agen cisplatin (CDDP) were explored and applied to elucidate various aspects of pharmacokinetics, drug distribution, chemomodulation and pharmacodynamics. An immunohistochemical assay for analysis of CDDP-DNA adducts, i.e. the drug in its probable target position, was modified to allow quantitation with computerized image analysis. The methodologi

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Popular Abstract in Swedish Den första beskrivningen av diabetes mellitus gjordes redan 1500 före Kristus när en faraos läkare noterade att myror samlade sig omkring urin från vissa människor men inte andras. På 1700-talet beskrevs för första gången närvaron av större mängder socker i såväl blod som urin hos diabetiska patienter. På 1920-talet upptäcktes insulin i bukspottkörteln (pancreas) och saThe influence of trauma (acute pancreatitis) or total parenteral nutrition (TPN) on pancreatic islet hormone secretion in relation to islet expression of inducible nitric oxide synthase (iNOS) was investigated. Acute pancreatitis resulted in an impaired glucose-stimulated insulin secretion (GSIS) which was found to be parallelled by a marked expression of iNOS and an exaggerated NO production in t

This article deals with Gunnar Rosendal within church politics in a European perspective. The term church politics is here used in a broad sense, referring to the church’s management of internal problems and conflicts as well as the political strategies of the church in its relation to state and society. In my study I focus on three fields that in various ways got church political consequences or This article deals with Gunnar Rosendal within church politics in a European perspective. The term church politics is here used in a broad sense, referring to the church’s management of internal problems and conflicts as well as the political strategies of the church in its relation to state and society. In my study I focus on three fields that in various ways got church political consequences o

Popular Abstract in Swedish Enligt ordboken betyder störning något som är avvikande från det normala. I den ekologiska begreppsvärlden är det tvärtom en del av det normala. Störning är en förutsättning för att många kulturmarker med hög biodiversitet ska kunna skapas och bevaras. I denna avhandling undersöktes hur markstörning i form av plöjning och harvning i torra gräsmarker påverkar mångfalden Many ecosystems have historically been disturbed, either naturally or as part of a cultural management. Due to loss of species as a result of too little disturbance, disturbance must be considered as a potential tool for conservation and restoration in various ecosystems. In this thesis work, disturbance effects on a grassland system were studied. The studied grassland had traditionally been sever