Inconel 718 is one type of nickel-based alloy used for a large range of applications, including gas turbines and aeroengines components. Although mechanical and thermodynamic properties of this material have been deeply studied in the past years, a method able to investigate local properties of the thin white layer formed on the alloy surface after machining remains challenging. Here, a 90 nm X-ra

Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identif

High-fat diet-induced metabolic changes are not restricted to the onset of cardiovascular diseases, but also include effects on brain functions related to learning and memory. This study aimed to evaluate mitochondrial markers and function, as well as cognitive function, in a rat model of metabolic dysfunction. Eight-week-old male Wistar rats were subjected to either a control diet or a two-hit pr

The main objectives of bioprocesses are to reliably deliver drugs in a relatively short time frame with high quality within a tight regulatory framework. Bioprocesses are highly complex, the level of automation is moderate, and there is constant pressure to improve efficiency and costs. In addition, climate change and resource scarcity mandate a reduction in the environmental footprint of bioproce

Findings on the correlation between the use of antihypertensive medication and the risk of breast cancer (BC) have been inconsistent. We performed a two-sample Mendelian randomization (MR) using instrumental variables to proxy changes in gene expressions of antihypertensive medication targets to interrogate this. Genetic instruments for expression of antihypertensive drug target genes were identif

Research on creative organizations often highlights a concern that economic influences on creative work might crowd out aesthetic influences. How this concern can be managed, however, is not well understood. Using a case study of an economic/aesthetic conflict within a design firm, we develop theory to describe how the economic and aesthetic can be constructively combined. We propose the concept o

Our title is a play on Nietzsche’s Schopenhauer as Educator first published in his essay collection Unfashionable Observations. Within the setting of teaching and studying management practice our chapter is also unfashionable. It argues for a primacy of honesty in feeling in a practice that can encourage the rational selection and manipulation of viewpoints. It argues for cheerful and generous exp

In this article we focus on the study of history through the use of narratives, within the context of the prevalent form of organization worldwide: the family business. Specifically we consider the dilemma of the impossible gift of succession using Nietzsche’s discussion of the burden of history and paralleling the story of a family business succession with that of Shakespeare’s King Lear. This wa

We challenge the obvious and easy association of enterprise and entrepreneurship. We do so by arguing that entrepreneurship is inherently social and collective, something that is concealed when held up as example of enterprising behaviour. We use as an illustrative case the Chinese artist Ai Weiwei, an example of entrepreneurship that has little to do with commerce and everything to do with the so