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Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning

Pesticides account for hundreds of millions of cases of acute poisoning worldwide each year, with organophosphates (OPs) being responsible for the majority of all pesticide-related deaths. OPs inhibit the enzyme acetylcholinesterase (AChE), which leads to impairment of the central- and peripheral nervous system. Current standard of care (SOC) alleviates acute neurologic-, cardiovascular- and respi

Investigating pathways for predisposing, enabling and need factors in predicting the use of STI/HIV-testing services among Syrian and Iraqi migrants in Scania, Sweden – a cross-sectional study with directed acyclic graphs for modelling pathways to testing

Background: Some groups of migrants have increased vulnerability to Sexually Transmitted Infections (STI) and Human Immunodeficiency Virus (HIV) transmission partly due to a lower uptake of disease preventive activities targeting the general population in receiving country. Limited access to economic and social resources and poor language skills may exacerbate exposure to sexual risks and utilizat

A micromechanically motivated multiscale approach for residual distortion in laser powder bed fusion processes

For the broader industrial usage of metal additive manufactured parts, especially made by laser powder bed fusion, a better prediction and understanding of the warpage and of eigenstresses within the final part are necessary. Due to the diverse and sophisticated metallurgical and thermal processes during production, physically motivated simulations are rather complex and time consuming. Therefore,

Context-based sensing of orthosomycin antibiotics by the translating ribosome

Orthosomycin antibiotics inhibit protein synthesis by binding to the large ribosomal subunit in the tRNA accommodation corridor, which is traversed by incoming aminoacyl-tRNAs. Structural and biochemical studies suggested that orthosomycins block accommodation of any aminoacyl-tRNAs in the ribosomal A-site. However, the mode of action of orthosomycins in vivo remained unknown. Here, by carrying ou

Age and gender relations on LinkedIn pages of global staffing agencies

This study investigates the ways in which age and gender play out on the LinkedIn pages of global staffing agencies through an intersectionality lens. A discourse analysis of 437 LinkedIn posts (including visual images, captions, and comments) was conducted. This study found that the corporate discourse of diversity shaped the ways that age and gender were represented. The portrayals of age and ge

Thoughts on the end of life in patients with oxygen-dependent chronic obstructive pulmonary disease : A qualitative interview study

Aim: The aim of the study was to deepen the current knowledge of how patients with chronic obstructive pulmonary disease and long-term oxygen treatment think about and expect end-of-life. Design: A qualitative design was used. Methods: A purposeful sample of 19 patients with oxygen-dependent chronic obstructive pulmonary disease was obtained from the Swedish National Registry on Respiratory Failur

Some Results on Oscillation Stability in Multi-Mode Harmonic Oscillators

We study the stability of oscillation in two different multi-mode harmonic oscillators by means of Barkhausen’s criterion, involving a minimum of mathematical machinery in favor of a more intuitive, circuit-based approach. The results of the theoretical analysis match very closely those obtained through transient simulations, confirming occasionally surprising outcomes of the latter.

Fast Electromagnetic Validations of Large-Scale Digital Coding Metasurfaces Accelerated by Recurrence Rebuild and Retrieval Method

The recurrence rebuild and retrieval method (R3M) is proposed in this paper to accelerate the electromagnetic (EM) validations of large-scale digital coding metasurfaces (DCMs). R3M aims to accelerate the EM validations of DCMs with varied codebooks, which involves the analysis of a group of similar but not identical structures. The method transforms general DCMs to rigorously periodic arrays by r

Can heavy metal pollution induce soil bacterial community resistance to antibiotics in boreal forests?

The emergence of microbial antibiotic resistance is a central threat to global health, food security, and development. It has been shown that heavy metal pollution can give rise to microbial resistance to antibiotics, but how wide-spread this phenomenon is remains an open question that urgently needs filling to enable appropriate environmental risk assessments. Here, we determined whether long-ter

Retinal regions shape human and murine Müller cell proteome profile and functionality

The human macula is a highly specialized retinal region with pit-like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We compared proteomic data from cone- and rod-rich retinae from human and mice and identified different expression profiles of cone- and rod-associated Müller cells that converg

Governing Emotions : Hybrid media, Ontological Insecurity and the Normalisation of Far-Right Fantasies

Focusing on the debates on ‘due impartiality’ provided to far-right leaders in Swedish media, this article uses a Lacanian approach to address the relationship between the practices of normalisation of far-right discourses and fantasies, and the evolution of emotional governance at the interstice of old (i.e. traditional) and new (e.g. social media) media. Emotional governance refers to the everyd

Genetic differences between suicide deaths and deaths of undetermined intent

Introduction: Few, if any, prior studies have considered whether undetermined intent (UDI) deaths and suicide deaths differ with respect to genetic liability for suicidal behavior or psychopathology. Methods: The authors used Swedish national registry data to identify suicide deaths (N = 31,835) and UDI deaths (N = 10,623); sociodemographic covariates; and registrations for psychopathology. Family

Size distribution of exhaled aerosol particles containing SARS-CoV-2 RNA

Background: SARS-CoV-2 in exhaled aerosols is considered an important contributor to the spread of COVID-19. However, characterizing the size distribution of virus-containing aerosol particles has been challenging as high concentrations of SARS-CoV-2 in exhaled air is mainly present close to symptom onset. We present a case study of a person with COVID-19 who was able to participate in extensive m

Tartrate resistant acid phosphatase 5 (TRAP5) mediates immune cell recruitment in a murine model of pulmonary bacterial infection

Introduction: During airway infection, upregulation of proinflammatory cytokines and subsequent immune cell recruitment is essential to mitigate bacterial infection. Conversely, during prolonged and non-resolving airway inflammation, neutrophils contribute to tissue damage and remodeling. This occurs during diseases including cystic fibrosis (CF) and COPD where bacterial pathogens, not least Pseud

Interstitial hydrogen diffusion in M7C3 (M = Cr, Mn, Fe),

To increase the understanding of the role of carbide precipitates on the hydrogen embrittlement of martensiticsteels, we have performed a density functional theory study on the solution energies and energy barriers forhydrogen diffusion in orthorhombic M7C3 (M = Cr, Mn, Fe). Hydrogen can easily diffuse into the lattice andcause internal stresses or bond weakening, which may promote reduced ductili

Vocal iconicity in nominal classification

While recent years have seen a substantial increase of studies investigating vocal iconicity in the lexicon of spoken languages, its presence in grammatical structures is poorly understood. This study investigates the presence of vocal iconicity in nominal classification systems by collecting nominal classification devices from the two main system types: 210 non-agreeing languages (126 families) a