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Neurogenesis in the adult mammalian brain is well studied, in the two main regions subventricular zone (SVZ) and subgranular zone (SGZ), under different physiological and pathological condition. Recent studies also revealed newly formed neurons in other parts of the brain including the hypothalamus. However, how robust neurogensis in this area is, is still unclear. In this study we used a novel re
Funktionell analys av HPV16 E5 mRNAn Humant papillomvirus (HPV) är ett litet DNA virus som infekterar hudens stamceller. De utgör den vanligaste sexuellt överförbara virusinfektionen ibland människor. HPV är också den bakomliggande orsaken till mer 99 % av alla livmoderhalscancer, speciellt typ 16. Denna cancerform skördar flest kvinnoliv efter bröstcancer varje år. I de flesta fall fullbordar HPThe E5 protein of Human Papillomavirus type 16 has been described as an oncoprotein, interacting with several cellular pathways to evade immune- and stress responses, enhancing E6- and E7- driven cell proliferation. However, it is not known when during the infection E5 is expressed. Although present on the majority of alternatively spliced mRNAs produced during the viral life cycle, E5 is never th
With more than half the world’s population living in ever more economically productive cities, and urbanisation continuing apace, large-scale environmental problems resulting from unsustainable, excessively consumption-focussed life styles are doomed to happen. Meanwhile large amounts of equipment and infrastructure are barely used. The recently emerged Sharing City concept combines the benefits o
I takt med att det har blivit dyrare för bolag att marknadsföra sig själva genom de traditionella marknadsföringsmetoderna har bolag börjat leta efter nya och kostnadseffektiva marknadsföringsalternativ. Sponsring har därför under de senaste åren blivit allt mer populärt. Detta märks inte minst genom att sponsring blivit allt vanligare under idrottsevenemang där bolag använder idrotternas goodwillIn recent year it has been more expensive than ever for companies to promote themselves via different marketing strategies. The companies have been looking for new and cost-effective alternatives instead of the classic marketing strategies. Sponsorship is one such strategy that has proven very popular, especially sponsorship during sporting events, where companies use the goodwill of sports to str
Syftet med denna uppsats är att beskriva och analysera SMF:s förutsättningar för att använda affärsmodellen som hjälpmedel för att kommunicera och driva strategisk förändring. Vi vill kontrastera dessa mot den befintliga forskningen om affärsmodeller och se om det finns skillnader mellan SMF och stora företag i förutsättningarna för användandet av affärsmodell som hjälpmedel. Uppsatsen är en kvaliThe purpose of this study is to describe and analyze conditions SMEs face to use the business model to communicate and implement strategic change. We wish to compare these factors to the current literature on business models and explain differences between SME and bigger companies conditions. The purpose has been examined through a qualitative study. A case study has been conducted on one company
Using unbalanced panel data for the sample period 2002-2012, this study investigates the relation between macroeconomic factors and the capital structure of 233 Swedish companies. Using the Random Effects model, this paper identifies the macroeconomic determinants that affect the capital structure of Swedish firms. We find that the leverage measures are positively related to the GDP Growth rate, I
This paper investigates the association between infant mortality and macroeconomic shocks in the Dominican Republic, using the 2002 and 2007 Demographic and Health (DHS) surveys. The article starts by reviewing the recent evolution of macroeconomic and social indicators in the country, as well as infant mortality trends calculated from the DHS surveys. It then proceeds to estimate logit and s
Bakgrund: En stor utmaning inom klädindustrin är att kombinera produkters korta livscykler med de komplexa försörjningskedjornas långa ledtider. Följaktligen finns det ett antal supply chain-strategier som hanterar utmaningen olika: kostnadseffektiva, responsiva och resultatdrivna som fokuserar på ett större antal aspekter. Dessa olika strategier lokaliserar outsourcad och offshorad produktion oliBackground: One of the main challenges in the fashion apparel industry is combining the products short lifetimes with the complex supply chains and long lead-times. There are thus several different types of supply chains that compete differently: the physically efficient, the market responsive and the outcome-driven supply chain. These supply chains locate outsourced and offshored production diffe
Bakgrund: Elektroniktillverkaren The Company implementerade för 4-5 år sedan en ABC-klassificeringsmodell för klassificering av de komponenter som de köper in. Nu vill företaget utmana den nuvarande modellen och utvärdera om de använder korrekta parametrar för klassificering, för att undersöka om det finns möjlighet till förbättring. Därför efterfrågar The Company en ny modell som baseras på den tBackground: The electronic manufacturing company The Company implemented a new model for ABC classification of supplied components about 4-5 years ago. Today, they want to challenge this model and evaluate if they have been using the correct parameters, or if improvement can be made. They wish for a new model that is based on the theory in field, to make a comparison with the existing model. The p
While evidence for man-made Climate Change has continuously increased, we witness insufficient changes in governmental policies. In many countries, even popular support for Green parties has decreased. This phenomenon reminds on an individual level of the psychological concept of procrastination. To overcome this problem, it seems necessary to broaden our understanding of this phenomenon and devel
Synergieffekter med ett avrinningsområdesperspektiv vid utformning av klimatstrategier Klimatförändringen ställer krav på naturmarken vi har i Sverige i form av utsläppsminskning, kolinlagring och klimatanpassning. Då avrinningen kan öka eller minska beroende på markanvändning är det viktigt med ett avrinningsområdets perspektiv vid utformningen av klimatstrategier. Det är särskilt angeläget då öClimate change places pressure on rural land in terms of carbon sequestration, biomass for substitution and adaptation of crops. Land use can both positively and negatively influence the runoff regime, therefor a catchment perspective is important when developing climate strategies. This is also important with respect to flood-risk that will increase with climate change. Here I investigate if ther
Under an action research paradigm, this thesis project explores the business potential of an environmental strategy and assesses the formulation of such a strategy implemented by an automotive original equipment manufacturer. Because of the heterogeneous nature of a company’s approach to environmental issues due to inter alia managerial conducts and company culture, this article provides an in-dep
European oceans are in a poor state – only 10% of marine habitats and 2% of marine species show favourable conservation status. This is largely attributed to an intense pressure from industrial human activities at sea. The Marine Strategy Framework Directive (MSFD) from 2008 is an attempt to better protect marine environments in the European Union (EU) by enforcing an Ecosystem-Based Management (E
Over the past ten years, there has been a substantial increase in corporate sustainability per-formance coupled with a need to voluntarily and publicly report on these issues. The current prominent and legitimate guidelines framing companies’ sustainability reporting practices are those proposed by the Global Reporting Initiative (GRI). In addition to providing a frame-work applicable for all type
Leverantörsutveckling började under och efter andra världskriget att utvecklas i Japan. Traditionellt sett fokuserade industrin på leverantörer med lågt inköpspris och att byta ut leverantörer som inte presterade tillräckligt bra. Idag är det emellertid känt att byte av leverantörer inte är kostnadseffektivt och därmed har vikten av leverantörsutveckling ökat. Detta är även tydligt då både industrSupplier development was established during and after World War II in Japan. The industry is moving from a traditional approach where low purchasing price were the main focus and supplier switching was common. Today the high price of supplier switching is well known and the importance of supplier development has increased both in research and in the industry. When companies focus more and more on
Geokronologi och paleomagnetiska studier är de viktigaste verktygen för paleogeografiska rekonstruktioner kring hur kontinenter fårhållit sig relativt till varandra under geologisk tid. Genom att jämföra s.k. polvandringskurvor och tidpunkter för storskaliga magmatiska händelser mellan olika krustala block (kontienter/kratoner) kan vi få en bättre förståelse av hur dessa block förhöll sig relativtRobust geochronology and well-constrained paleopoles are the main tools for paleogeographic reconstructions. Through the completion of so called barcode diagrams (matching of coeval events of mafic magmatism between blocks) and determination of the apparent polar wander paths, these studies provide a better understanding of the position of continents and supercontinents in the past. The robust U–P
Globally, aviation biofuel (biojet) technology has reached a degree of progress that allows immediate substitution of conventional fossil fuel in commercial air travel. However,numerous factors constitute an impediment to its large-scale use and deployment: a diagnostic analysis identifying key obstacles to biojet development is needed. For this reason, an examination of actors, institutions and a
The MENA (Middle East and North Africa) region enjoys a high availability of clean renewable energy sources, especially solar. In recent years, several countries within the region have introduced policy instruments to encourage the deployment of distributed solar photovoltaic (PV). This thesis reviews and evaluates policy instruments adopted in Egypt, Palestine and Tunisia. The experiences from th
Transnational Municipal Networks (TMNs) are prominent networks in the international climate governance arena serving as drivers of and advocates for local action on climate change. The main objective of this exploratory research is to establish the relation between the internal governance structure of the TMNs and their ability to carry out certain types of activities. Internal governance encompas
Standardmodellen, vår nuvarande fysikaliska modell för att beskriva fundamentalpartiklar och deras växelverkan, har mött en enorm framgång genom åren – samtliga partiklar och växelverkningar som standardmodellen beskriver har bekräftats experimentellt. Standardmodellen har dock problem med att förklara vissa egenskaper hos partiklarna,och den är inte förenlig med gravitationskraften; en av de fyraThe ability to identify boosted top quarks will be of great importance in searches for new physics at the LHC, as boosted tops play an important role in many scenarios of physics beyond the Standard Model. One top tagging algorithm that has been successfully used in the ATLAS collaboration is the HEPTopTagger, which exploits the clustering history of Cambridge/Aachen (C/A) jets to filter out every
