Phosphorylation is a protein post-translational modification (PTM) that plays an important role in cell signaling, cell differentiation, and metabolism. The hyper phosphorylated forms of certain proteins have been appointed as biomarkers for neurodegenerative diseases, and phosphorylation-related mutations are important for detecting cancer pathways. Due to the low abundance of phosphorylated prot

The electric resistance is very important for the performance of a proton exchange membrane (PEM) fuel cell. However, the performance analysis is more complex as the cell operates under assembly conditions. At such conditions, the mass transfer is deteriorated but the electric conductivity is favored. In this paper, the electric resistance of a cell is evaluated by application of a recently develo

Ecological intensification of agriculture implies managing ecological processes to improve performance of agricultural systems. However, impacts on relevant ecological functions such as insect pollination from other crop management factors are poorly explored. Pest insects and crop resources such as water availability can directly affect crop yields, but it is unknown if there are indirect effects

This work investigates the problem of how to reduce the prime cost of Grade Q125 Group 4 casing and tubing according to API 5CT and proposes process solutions to resolve it, consisting in the enhancement of series of mechanical properties without chemical alloying of steel with expensive elements such as chromium, molybdenum, vanadium, niobium and boron. During the investigation the process parame

Conventional 3D organic-inorganic halide perovskites have recently undergone unprecedented rapid development. Yet, their inherent instabilities over moisture, light, and heat remain a crucial challenge prior to the realization of commercialization. By contrast, the emerging 2D Ruddlesden-Popper-type perovskites have recently attracted increasing attention owing to their great environmental stabili

The objective of the present study is the investigation of possibilities for boosting peptide antiinflammatory effects by tryptophan end-tagging, including identification of underlying mechanisms for this. In doing so, effects of tryptophan end-tagging of KYE21 (KYEITTIHNLFRKLTHRLFRR), a peptide derived from heparin co-factor II, on membrane and lipopolysaccharide (LPS) interactions were investiga

Objective To evaluate the effectiveness of oral glucosamine in subgroups of people with hip or knee osteoarthritis (OA) based on baseline pain severity, body mass index (BMI), sex, structural abnormalities and presence of inflammation using individual patient data. Methods After a systematic search of the literature and clinical trial registries, all randomised controlled trials (RCTs) evaluating

Dispersal is important for determining both species ecological processes, such as population viability, and its evolutionary processes, like gene flow and local adaptation. Yet obtaining accurate estimates in the wild through direct observation can be challenging or even impossible, particularly over large spatial and temporal scales. Genotyping many individuals from wild populations can provide d

Following the appearance of numerous animal phyla during the 'Cambrian Explosion', the 'Great Ordovician Biodiversification Event' (GOBE) records their rapid diversification at the lower taxonomic levels, constituting the most significant rise in biodiversity in Earth's history. Recent studies suggest that the rapid rise in phytoplankton diversity observed at the Cambrian-Ordovician boundary may h

This paper presents a new direct electron transfer based-miniaturized glucose/oxygen enzymatic fuel cell (EFC) whose operating ability has been tested in real saliva samples. The bioanode and biocathode are a graphene working electrode and a graphite counter electrode localized on the same screen printed electrode (SPE) modified with poly(vinyl alcohol) N-methyl-4(4'-formylstyryl)pyridinium methos

Objectives To determine the causes of death and risk factors in systemic sclerosis (SSc). Methods Between 2000 and 2011, we examined the death certificates of all French patients with SSc to determine causes of death. Then we examined causes of death and developed a score associated with all-cause mortality from the international European Scleroderma Trials and Research (EUSTAR) database. Candidat

Why do some forests produce biomass more efficiently than others? Variations in Carbon Use Efficiency (CUE: total Net Primary Production (NPP)/ Gross Primary Production (GPP)) may be due to changes in wood residence time (Biomass/NPPwood), temperature, or soil nutrient status. We tested these hypotheses in 14, one ha plots across Amazonian and Andean forests where we measured most key components o