Colorectal cancer (CRC) is one of the major causes of cancer globally. Recent studies proposed a role for cancer initiating cells (CICs), a small subset of replication-competent cells, in colon carcinogenesis. Although the role of inflammatory lipid-mediators in CRC progression is well known, their role in the promotion of cancer-initiating cells remains to be elucidated. For this thesis, we inves

A critical review of Carlos Castaneda's work.

The current and future emissions regulations and demands on internal combustion engines have increased the need for improvement of the thermal design and engine ef ciency. This paper reports an initial investigation concerning in-cylinder heat transfer. In addition, a literature review in this eld is presented. It was found that no extensive application studies have been performed on full cylinder

Popular Abstract in English Sweden’s elderly population is growing, propelled by a continuous decline in old-age mortality, while coupled with a persistent replacement level fertility. This changing age structure increases the per worker cost of providing a given age-vector of per capita benefits, encompassing costs for pensions, health care, and all other type of old-age welfare services, which pSweden’s elderly population is growing, propelled by a continuous decline in old-age mortality, while coupled with a persistent replacement level fertility. This changing age structure increases the per worker cost of providing a given age-vector of per capita benefits, encompassing costs for pensions, health care, and all other type of old-age welfare services, which presents a looming challenge

Symmetric protein dimers, trimers, and higher-order cyclic oligomers play key roles in many biological processes. However, structural studies of oligomeric systems by solution NMR can be difficult due to slow tumbling of the system and the difficulty in identifying NOE interactions across protein interfaces. Here, we present an automated method (RosettaOligomers) for determining the solution struc

AimsTo determine whether antivirus and/or islet cell antibodies can be detected in healthy pregnant mothers without diabetes and/or their offspring at birth in two winter viral seasons. MethodsMaternal and cord blood sera from 107 healthy pregnant women were tested for islet cell autoantibodies using radioligand binding assays and for anti-rotavirus and anti-CoxB3 antibody using an enzyme-linked i

In birds, fat accumulation before and during migration has been shown to be endogenously controlled and tuned by, among other factors, the Earth's magnetic field. However, our knowledge about the influence of the geomagnetic field on the fuelling in migrating birds is still limited to just a few nocturnally migrating passerine species. In order to study if variations of the magnetic field can also

Aims. We describe how the C IV lambda 1548.18 line pumps the 1548.20 and 1548.41 angstrom channels of Fe II in symbiotic stars through the process known as photo-ionization by accidental resonance (PAR). We describe where and why Fe II fluorescence arises in symbiotic stars and whether the Fe II lambda 1548.41 channel can only be activated when there is a white-dwarf wind present in the system. Fu

We present a set of spectrally and temporally resolved clinical fluorescence data-with two separate excitation wavelengths-that was recorded in vivo. We demonstrate that data in the spectral and temporal domains are in certain ways coupled and provide a method for integrated and effective parameterization of spectrally and temporally resolved fluorescence (i.e., time-resolved emission spectra). Th

A survey on household waste sorting and disposal habits was conducted in Sweden to investigate behavioral patterns of recycling in a context in which wide measures are taken to promote and encourage pro-environmental behavior by making it easy and convenient. 207 residents of three cities in southern Sweden, Lund, Malmö and Helsingborg, responded to an online questionnaire survey. Relations betwee

Most climate change scenarios predict that the variability of weather conditions will increase in coming decades. Hence, the frequency and intensity of freeze-thaw cycles in high-latitude regions are likely to increase, with concomitant effect on soil carbon biogeochemistry and associated microbial processes. To address this issue we sampled riparian soil from a Swedish boreal forest and applied t

The move towards fire performance-based design in building and transport regulations has led to an increased use of fire models. This increased use of these models and the evolution of different regulations have put higher demands on the predictive capability of fire models. The purpose of this paper is to give an overview of different activities relating to the validation and verification of comp

Tasquinimod, an orally active quinoline-3-carboxamide, binds with high affinity to HDAC4 and S100A9 in cancer and infiltrating host cells within compromised tumor microenvironment inhibiting adaptive survival pathways needed for an angiogenic response. Clinical trials document that as low as 0.5-1mg tasquinimod/day is therapeutic against castrate resistant metastatic prostate cancer. Tasquinimod i

A method to compute distributed dipole-quadrupole polarizabilities is suggested. The method is based on numerical differentiation of distributed quadrupole moments, using finite field perturbation calculations. It is tested using two different multicenter multipole expansions, and compared with results using polarizabilities obtained via the uncoupled Hartree-Fock approximation. The accuracy of th

Abstract in UndeterminedGaps in measured discharge series are common in Iceland, especially during winter, but reconstructed series are needed for a number of applications. Modeled series are therefore sometimes used to fill the gaps to create a continuous series, but the modeled inserts may have different statistical characteristics from the observed series, whilst their initial and final values