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Fibril formation of islet amyloid polypeptide (IAPP) is associated with cell death of the insulin-producing pancreatic beta-cells in patients with Type 2 Diabetes Mellitus. A likely cause for the cytotoxicity of human TAPP is that it destroys the barrier properties of the cell membrane. Here, we show by fluorescence confocal microscopy on lipid vesicles that the process of hIAPP amyloid formation

Artikeln belyser hur traditionella troper inom negativ eller apofatisk teologi genljuder inom nutida postmodern filosofi.

The hybodont form genus Lissodus is taken under revision and found to comprise a number of lineages. Twelve species, stratigraphically extended from the Scythian, Lower Triassic to the Albian, Lower Cretaceous, are retained in Lissodus s.s. Thirteen other species can be included in Lonchidion, here considered as a justified genus, ranging from the Ladinian in the Middle Triassic to the Maastrichti

Electrically active defects induced by electron irradiation in Czochralski (Cz)grown Si crystals with low carbon content (N-C <= 2 x 10(15) cm(-3)) have been studied by means of Hall effect measurements, deep level transient spectroscopy (DLTS) and high-resolution Laplace DLTS (LDLTS). It has been found that in n-type carbon-lean Cz-Si irradiated at room temperature a centre with an acceptor level

The relative significance of weak non-covalent interactions in biological context has been much debated. Here, we have addressed the contribution of Coulombic interactions to protein stability and assembly experimentally. The sweet protein monellin, a non-covalently linked heterodimeric protein, was chosen for this study because of its ability to spontaneously reconstitute from separated fragments

Empowerment has become a widespread concept in various social policy contexts referring to different marginalized groups. Empowerment has also been focused within the mental health field although little empirical research exists. The aim of the present study was to investigate internal consistency and construct validity of the Swedish version of an empowerment scale developed for people with a men

Service screening with mammography was implemented in Sweden in the late 80's, following the results from trials in Sweden and abroad. A high rate of attendance, a high diagnostic accuracy and treatment in accordance with established guidelines are key circumstances for an effective screening programme. These factors have to be continuously monitored. One trial was carried out 1976-86 in the city

Popular Abstract in Swedish En ny mätuppställning har utvecklats och tillämpats på öronproppar (hörselproppar). Mätuppställning gör det möjligt att skatta de akustiska egenskaperna i form av en så kallad tvåport. För objektiva mätningar på hörselskydd använder man normalt sett någon form av artificiellt huvud eller öra, med vars hjälp man mäter insättningsdämpningen. Denna insättningsdämpning beskIn this study an experimental setup for measurements of high impedance objects in ducts, yielding the acoustical Two-Port properties of the object, is applied to earplugs. A frequently used experimental setup for measuring objective acoustical properties of earplugs is that of artificial ears. Great effort is spent on duplicating the human ear. The acoustical properties of the earplug are thought

This article reports a literature review which draws together findings targeting families' needs when a child is long-term ill. The databases PubMed and CINHAL were searched from 1999 to 2003 during February 2004. The search terms were child health care, family caregivers, and needs and combinations of these. The search was limited to articles published in English and the Scandinavian languages. T

We have investigated the properties of cobalamin complexes with imidazolate using the density functional B3LYP method, In particular, we have compared imidazolate (Imm) with imidazole and 5,6-dimethylbenzimidazole (DMB), and studied how constraints in the axial Co-N bond length may affect the strength of the Co-C bond. The results show that the optimum Co-N-Imm bond is similar to0.2 Angstrom short

Decreased estrogen production is associated with changes in the skeletal, cardiovascular and muscular systems. At the level of skeletal muscles, it has been shown that a reduction in force production occurs at menopause but the underlying mechanisms are still unknown. The aim of the study was to investigate the effects of ovariectomy on myosin heavy chain (MyHC) composition. Additionally, we studi

A laboratory study was executed to investigate the effect of surfactants to enhance sorption of polycyclic aromatic hydrocarbon (PAH) contaminants in loess soil. Phenanthrene and naphthalene were chosen as organic contaminant indicators in loess soil modi. fied by the cation surfactant hexadecyltrimethylammonium (HDTMA) bromide. The kinetic behavior of sorption during transport in natural and modi

Organic dementia is dominated by primary degenerative disorders such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). FTD is a distinct clinical syndrome with behavioural, personality, emotional and language disturbances preceding the cognitive decline. This clinical presentation is distinctly different from that of AD which is characterized by early cognitive changes, such as memory

Allergic rhinitis is an inflammatory nasal disorder in which a range of different cells participates. A variety of approaches has been used to monitor nasal inflammation objectively to investigate disease processes and to evaluate the effect of therapeutic intervention. These approaches include nasal lavage, nasal cytology, and nasal biopsy, together with the more recently established measurement

In this paper we analyze the performance of three low-complexity channel estimators, based on the discrete Fourier transform (DFT), for orthogonal frequency-division multiplexing (OFDM) systems. Estimators of this type have been analyzed for discrete-time channels, and we extend this analysis to continuous-time channels. We present analytical expressions for their mean-squared error (MSE) and eval