Analogs of the incretin hormones Gip and Glp-1 are used to treat type 2 diabetes and obesity. Findings in experimental models suggest that manipulating several hormones simultaneously may be more effective. To identify small molecules that increase the number of incretin-expressing cells, we established a high-throughput in vivo chemical screen by using the gip promoter to drive the expression of

We analyzed the morphology and the transcriptomic changes of human neural stem progenitor cells (hNSPCs) grown on laminin in adherent culture conditions and subjected to simulated microgravity for different times in a random positioning machine apparatus. Low-cell-density cultures exposed to simulated microgravity for 24 h showed cell aggregate formation and significant modulation of several genes

We measured CO2 and CH4 fluxes using chambers and eddy covariance (only CO2) from a moist moss tundra in Svalbard. The average net ecosystem exchange (NEE) during the summer (9 June–31 August) was negative (sink), with −0.139 ± 0.032 µmol m−2 s−1 corresponding to −11.8 g C m−2 for the whole summer. The cumulated NEE over the whole growing season (day no. 160 to 284) was −2.5 g C m−2. The CH4 flux

The tools for spectrally analyzing heart rate variability (HRV) has in recent years grown considerably, with emphasis on the handling of time-varying conditions and confounding factors. Time–frequency analysis holds since long an important position in HRV analysis, however, this technique cannot alone handle a mean heart rate or a respiratory frequency which vary over time. Overlapping

The self-assembly of an arylazopyrazole-based photosurfactant (PS), based on cetyltrimethylammonium bromide (CTAB), and its mixed micelle formation with CTAB in aqueous solution was investigated by small angle neutron and X-ray scattering (SANS/SAXS) and UV-vis absorption spectroscopy. Upon UV light exposure, PS photoisomerizes from E-PS (trans) to Z-PS (cis), which transforms oblate ellipsoidal m

This article contributes to the emerging body of literature which investigates the mechanisms through which funding conditions affect research. It is an interview-based case study of the Distinguished Professor Grant (DPG); an excellence funding instrument aimed at individuals. The study uses the concept of “protected space” to explore the epistemic and organizational dynamics enabled by the DPG.

A coworker teased me a few months ago, describing requirements engineering (RE) as "plumbing,"something he absolutely considered functional, even necessary, but otherwise best not discussed in polite conversation. I responded with a graphically descriptive suggestion of what one might experience with a plumbing failure. I then drew parallels to a situation where a team's excellent execution of the

The production, transport, and deposition of mineral dust exert major influences on climate change and Earth’s biogeochemical cycles. Furthermore, their imprint, as recorded in pelagic sediments, provides an avenue for determining past changes in terrestrial aridity and atmospheric circulation patterns in response to global climate change. Here, by examining geochemical and magnetic data obtained

Marble in the supracrustal rocks of the Lewisian Complex, Tiree, includes chlorine-bearing amphiboles, chlorine-rich apatite, sulphur-rich scapolite, albite and phlogopite, all of which are regarded as evidence for evaporites in other metamorphosed sequences. Titanite yields U-Pb ages of ∼1.6 Ga, i.e. late Laxfordian, which excludes a younger imprint of sodium metasomatism. Traces of anhydrite, an

This paper explores the current process and practice of contingency planning in humanitarian organisations. It sets out the key terms and concepts relating to contingency planning, explores the contingency planning process, explains the main models used by humanitarian organisations and presents a new concept of the process that enables a more dynamic approach than previous frameworks.The paper al

Understanding the impact of the geometry and material composition of electrodes on the survival and behavior of retinal cells is of importance for both fundamental cell studies and neuromodulation applications. We investigate how dissociated retinal cells from C57BL/6J mice interact with electrodes made of vertically-aligned carbon nanotubes grown on silicon dioxide substrates. We compare electrod

Background: Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations. Methods: We analysed targeted metabolomics data

This essay takes a starting point in the well-known tension between the media logic and the scientific logic and the challenges when communicating science in a mediatized society. Building on the experience of engaging in research comics, both as a method for communicating science and a creative example of a meeting between science and art, we introduce a framework — a pedagogical tool — for how sThis essay takes a starting point in the well-known tension between the media logic and the scientific logic and the challenges when communicating science in a mediatized society. Building on the experience of engaging in research comics, both as a method for communicating science and a creative example of a meeting between science and art, we introduce a framework — a pedagogical tool — for how s

Background: Sore throat is a common reason for prescribing antibiotics in primary care, and 10 days of treatment is recommended for patients with pharyngotonsillitis with group A streptococcus (GAS). Our group recently showed that penicillin V (PcV) four times daily for 5 days was non-inferior in clinical outcome to PcV three times daily for 10 days. This study compares duration, intensity of symp

This work aims to make three-dimensional (3D) tomographic techniques more flexible and accessible to in-situ measurements in practical apparatus by allowing arbitrary camera placements that benefit applications with more restrictive optical access. A highly customizable, in-house developed tomographic method is presented, applying smoothness priors through Laplacian matrices and hull constraints b

he effect of viscosity on the nasal absorption and biological response to desmopressin was studied in humans. Nasal solutions of desmopressin with and without the addition of 0.25% (w/v) methylcellulose were administered by a precompression nasal spray pump to 10 volunteers. Plasma levels of desmopressin were assayed by radioimmunoassay and the biological response was measured by determination of

We focus on the task of estimating a physically plausi-ble articulated human motion from monocular video. Ex-isting approaches that do not consider physics often pro-duce temporally inconsistent output with motion artifacts, while state-of-the-art physics-based approaches have either been shown to work only in controlled laboratory conditions or consider simplified body-ground contact limited to f