Understanding Alzheimer’s disease (AD) heterogeneity is important for understanding the underlying pathophysiological mechanisms of AD. However, AD atrophy subtypes may reflect different disease stages or biologically distinct subtypes. Here we use longitudinal magnetic resonance imaging data (891 participants with AD dementia, 305 healthy control participants) from four international cohorts, and

Increasing rates of cancer incidence and the toxicity concerns of existing chemotherapeutic agents have intensified the research to explore more alternative routes to combat tumor. Luteolin, a flavone found in numerous fruits, vegetables, and herbs, has exhibited a number of biological activities, such as anticancer and anti-inflammatory. Luteolin inhibits tumor growth by targeting cellular proces

Background: Eating disorders (ED) are severe psychiatric conditions, characterized by decreased quality of life and high mortality. However, only a minority of patients with ED seek care and very few receive treatment. Internet-delivered cognitive behavioral therapy (ICBT) has the potential to increase access to evidence-based treatments. Aims: The aims of the present study were to (1) develop and

The role of public transport in society is crucial, particularly for those who do not have access to alternative transport modes. For public transport to be able to fulfil its societal role, it should not be perceived as unsafe or unhealthy by its (potential) users. Several studies from all over the world have shown that anxiety has increased remarkably during the pandemic, and it is likely to las

I examensarbetet har maskininlärning använts för att kombinera detektionen av röda blod-kroppar och blodplättar. En snabbare lösning i jämförelse med dagens separata algoritmer på företaget utformades, med prestanda i samma klass.Blood analysis is an integral part of diagnostic medicine and used in most medical fields. The concentrations of red blood cells and platelets, and ratio between these, are used for diagnosing several diseases. CellaVision develops machines and software for automatically capturing images of blood sample smears and detecting its cellular contents. The company currently has separate algorithms for d

Sweden was one of the first countries in the world to declare that it had a feminist government, following years of high rankings on global gender equality indexes and a relatively stable image of Sweden as a gender equality leader. However, the declaration has been accompanied by scholarly inquiry defying claims connected to Swedish feminist governance, often challenging its transformative capaci

Ceasing the pollution of greenhouse gasses will be the biggest challenge of the twentieth century. There is no one solution. Renewable energy sources include solar energy, hydropower, and many more. Just as we have to utilize all these different resources, designers will to the same extent need to explore and adopt new design strategies, upcycling being one of them. Despite all the benefits

Ground vibration generated by rail and road traffic is a major source of environmental noise and vibration pollution in the low-frequency range. A promising and cost-effective mitigation method could be the use of heavy masses placed as an array on the ground surface near the road or track, these could be concrete or stone blocks, or specially designed brick walls, for example. This work concerns

Postmastectomy radiotherapy (PMRT) following immediate breast reconstruction (IBR) is associated with postoperative complications. Although the incidence of node-positive breast cancer is declining, a separate sentinel lymph node biopsy (SLNB) is still performed before mastectomy when IBR is planned, in order to evaluate nodal status and the need for PMRT. This study assessed the impact of staged

The purpose of this research is to examine the effect of sandblasting on the initiation of stress corrosion cracking (SCC) in unidirectional E-glass/polymer composite materials with modified polyester, epoxy and vinyl ester resins. The composites with different amounts of surface damage due to sandblasting have been subjected to mechanical bending loads in the presence of nitric acid (pH=1.2). It

The filtered backprojection (FBP) algorithm is viewed as a preferred candidate for general bistatic synthetic aperture radar (BiSAR) imaging since it does not pose any restrictions on SAR configurations or flight paths. However, high-efficient autofocus methods such as phase gradient autofocus (PGA) or Mapdrift (MD) cannot be effectively integrated with the FBP algorithm due to the unknown propert

Although active transport contributes to environmental and human health, only limited research has been conducted on what makes people participate in active transport in tourism-related contexts. To fill this gap, research was conducted on theoretically conceptualized relationships between pro-social behavior on active transport, air quality, climate change mitigation, and health with a moderator

Evaporation is one of the main components of the hydrological cycle, and its estimation is crucial and important for water resources management issues. Access to a reliable estimator tool for evaporation simulation is important in arid and semi-arid areas such as Iran, which lose more than 70% of their received precipitation by evaporation. Current research employs the Bayesian Regularization (BR)

Protein complex formation is encoded by specific interactions at the atomic scale, but the computational cost of modeling proteins at this level often requires use of simplified energy models and limited conformational flexibility. In particular, use of all-atom energy functions and backbone and side-chain flexibility results in rugged energy landscapes that are difficult to explore. In this study

I länder med fria val finns demokratiska spelregler som gör att systemet i viss utsträckning redan är förutbestämt. Befolkningen har till exempel på förhand ett begränsat antal partier att välja mellan. Det finns också formella problem, som att fördelningen av mandat över ett land faktiskt kan bestämma utgången redan innan medborgarna gått till vallokalerna. I Demokratiparadoxen fördjupar sig prof

Analogs of the incretin hormones Gip and Glp-1 are used to treat type 2 diabetes and obesity. Findings in experimental models suggest that manipulating several hormones simultaneously may be more effective. To identify small molecules that increase the number of incretin-expressing cells, we established a high-throughput in vivo chemical screen by using the gip promoter to drive the expression of

We analyzed the morphology and the transcriptomic changes of human neural stem progenitor cells (hNSPCs) grown on laminin in adherent culture conditions and subjected to simulated microgravity for different times in a random positioning machine apparatus. Low-cell-density cultures exposed to simulated microgravity for 24 h showed cell aggregate formation and significant modulation of several genes

We measured CO2 and CH4 fluxes using chambers and eddy covariance (only CO2) from a moist moss tundra in Svalbard. The average net ecosystem exchange (NEE) during the summer (9 June–31 August) was negative (sink), with −0.139 ± 0.032 µmol m−2 s−1 corresponding to −11.8 g C m−2 for the whole summer. The cumulated NEE over the whole growing season (day no. 160 to 284) was −2.5 g C m−2. The CH4 flux