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Prediction of stopping-power ratios in flattening-filter free beams.
PURPOSE: In recent years, there has been an increasing interest in flattening-filter free (FFF) beams. However, since the removal of the flattening filter will affect both the mean and the variance of the energy spectrum, current beam-quality specifiers may not be adequate for reference dosimetry in such beams. The purpose of this work was to investigate an alternative, more general beam-quality s
Selective and simultaneous determination of trace bisphenol A and tebuconazole in vegetable and juice samples by membrane-based molecularly imprinted solid-phase extraction and HPLC
Nanofibrous molecularly imprinted membranes (nano-MIMs) with multi-analyte selectivity were prepared by encapsulating two types of molecularly imprinted polymer nanoparticles (MIP-NPs) into electrospun polyvinyl alcohol nanofibers. The obtained nano-MIMs maintained high molecular selectivity offered by each of the MIP-NPs. Nano-MIM embedding BPA-imprinted nanoparticles and TBZ-imprinted nanopartic
Real-world cost-effectiveness in chronic myeloid leukemia: the price of success during four decades of development from non-targeted treatment to imatinib
Imatinib has revolutionized the treatment of chronic myeloid leukemia (CML). We evaluated clinical outcome and cost-effectiveness, using Swedish registry data based on patients with CML diagnosed 1973-2008. Outcome from three time periods (I: 1973-1979; II: 1991-1997; III: 2002-2008) associated with symptomatic treatment, interferon-alpha/stem cell transplant and implementation of imatinib, respec
Photochemistry of carbon monoxide and methanol in water and nitric acid hydrate ices: A NEXAFS study
Soft X-ray induced chemistry of H2O, CO and CH3OH and the effects of the water and nitric acid hydrate (HNO3 center dot 1.65H(2)O) matrix on the photochemistry of CO and CH3OH have been investigated using NEXAFS spectroscopy. For pure H2O, CO and CH3OH ices, we show that the destruction rates are strongly limited by back reactions, leading to strikingly high survival rates of these molecules upon
Acute stress trajectories 1 year after a breast cancer diagnosis.
The purpose of this study was to evaluate the longitudinal trajectories of acute stress reactions over the course of diagnosis, treatment, and follow-up assessments in a group of non-metastatic breast cancer patients during five different moments of the illness process, and to identify psychological predictors of the trajectories.
QM/MM-PBSA method to estimate free energies for reactions in proteins
We have developed a method to estimate free energies of reactions in proteins, called QM/MM-PBSA. It estimates the internal energy of the reactive site by quantum mechanical (QM) calculations, whereas bonded, electrostatic, and van der Waals interactions with the surrounding protein are calculated at the molecular mechanics (MM) level. The electrostatic part of the solvation energy of the reactant
Supplemental Instruction: Whom Does It Serve?
Supplemental Instruction (SI) is today a well-known academic assistance program that provides help for students in "difficult" courses. SI has repeatedly been shown to decrease the percentage of failures in the course as well as increasing course grades for students who attended SI sessions. Although SI is open for all students, its main objective is to come to terms with students' high failure ra
Fine root dynamics along an elevational gradient in tropical Amazonian and Andean forests
The key role of tropical forest belowground carbon stocks and fluxes is well recognised as one of the main components of the terrestrial ecosystem carbon cycle. This study presents the first detailed investigation of spatial and temporal patterns of fine root stocks and fluxes in tropical forests along an elevational gradient, ranging from the Peruvian Andes (3020 m) to lowland Amazonia (194 m), w
Outcome and clinical changes in patients 3, 6, 12 months after a severe or major hand injury - can sense of coherence be an indicator for rehabilitation focus?
Background: Our objective was to explore outcome and clinical changes in hand function, satisfaction in daily occupations, sleep disturbances, health and quality of life in consecutive patients after a severe or major hand injury. Our objective was also to investigate possible differences between groups according to severity of injury, presence of peripheral nerve injury and the patients' sense of
Soft magnetic moldable composites: Properties and applications
A new type of electromagnetic soft magnetic material (SMM) is introduced, based on spherical iron powder particles and a suitable polymer binder. A key feature of this material is that it can be cast or molded into almost any 3D shape, hence the denotation soft magnetic moldable composite ((SMC)-C-2). The SM2C is compared with a set of reference materials, such as ferrites, laminated steels, and s
Grass pollen allergy in children and adolescents-symptoms, health related quality of life and the value of pollen prognosis
Sperm: seminal fluid interactions and the adjustment of sperm quality in relation to female attractiveness
Long-term effects of early parasite exposure on song duration and singing strategy in great tits
Song is a sexually selected trait in many bird species and has been suggested to function as a signal of a male's health and parasite resistance. Here we present an experimental field study on the long-term effects of parasite exposure early in life on adult bird song. We exposed nestling great tits (Parus major) to ectoparasitic hen fleas (Ceratophyllus gallinae) and on their recruitment into the
Ligands for C1q and factor H on the surface of apoptotic cells
Three Empirical Studies on the Agreement of Reviewers about the Quality of Software Engineer ing Experiments
Context: During systematic literature reviews it is necessary to assess the quality of empirical papers. Current guidelines suggest that two researchers should independently apply a quality checklist and any disagreements must be resolved. However, there is little empirical evidence concerning the effectiveness of these guidelines. Aims: This paper investigates the three techniques that can be use
$(\epsilon,\delta)$-Freudenthal Kantor triple systems, $\delta$-structurable algebras and Lie superalgebras
In this paper we discuss $(\epsilon,\delta)$-Freudenthal Kantor triple systems with certain structure on the subspace $L_{-2}$ of the corresponding standard embedding five graded Lie (super)algebra $L(\epsilon,\delta):=L_{-2}\oplus L_{-1}\oplus L_0\oplus L_1\oplus L_2; [L_i,L_j]\subseteq L_{i+j}$. We recall Lie and Jordan structures associated with $(\epsilon,\delta)$-Freudenthal Kantor triple sys
Adding realism to simulated sensors and actuators.
In this paper, we propose a statistical theoretical framework for incorporation of sensor and actuator faults in dynamic simulations of wastewater treatment operation. Sensor and actuator faults and failures are often neglected in simulations for control strategy development and testing, although it is well known that they represent a significant obstacle for realising control at full-scale facili
Atrioventricular nodal function during atrial fibrillation: Model building and robust estimation
Statistical modeling of atrioventricular (AV) nodal function during atrial fibrillation (AF) is revisited for the purpose of defining model properties and improving parameter estimation. The characterization of AV nodal pathways is made more detailed and the number of pathways is now determined by the Bayesian information criterion, rather than just producing a probability as was previously done.
Managing the needs of end-users in the design and delivery of construction projects
Purpose – The two-fold purpose of this paper is identifying areas of difficulty in managing the needs of end-users in the course of the design and delivery of construction projects and suggesting possible solutions. Design/methodology/approach – The focus of the paper is the interaction between three principal parties: end-users, project leader (a selected end-user) and facility planner (a facil
