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Importance: Alzheimer disease (AD) pathology starts with a prolonged phase of β-amyloid (Aβ) accumulation without symptoms. The duration of this phase differs greatly among individuals. While this disease phase has high relevance for clinical trial designs, it is currently unclear how to best predict the onset of clinical progression. Objective: To evaluate combinations of different plasma biomark

We have employed the cranked Nilsson-Strutinsky and cranked Nilsson-Strutinsky-Bogoliubov methods to predict the structure of the observed high-spin rotational bands in Nd137. Our study is motivated in particular by a previous observation of a rotational band more than 4 MeV above yrast. We discuss both possible interpretations of this band and in this connection also the HD band and the terminati

en diskussion om blickens betydelse i förhållande till film his Walter Benjamin, Marcel Duchamp och Lili Dujourie

Background: SARS-CoV-2 mRNA vaccination has been associated with both side effects and a reduction in COVID-related complaints due to the decrease in COVID-19 incidence. We aimed to investigate if individuals who received three doses of SARS-CoV-2 mRNA vaccines had a lower incidence of (a) medical complaints and (b) COVID-19-related medical complaints, both as seen in primary care, when compared t

en analys av den norske konstnären och fotografen Per Manings arbete

En första presentation och analys av målaren Fredrik Vaerslevs konstnärskap

analys av konstnären Luca Freis konstnärskapText in publication on the occasion of the Luca Frei exhibitions The Fifth Business (Bonner Kunstverein, 2012) and Thursday followed… (Kunsthaus Glarus, 2013)

En presentation av den isländske konstnären Georg Gudni

Kan en silkeshandske vara en symbol för makt? I denna tänkvärda volym samlas en grupp namnkunniga historiker för att ge perspektiv på överlappande frågor kring genus, materialitet och politik. Genom historiska fallstudier som sträcker sig från 1500-talet och fram i modern tid utforskar författarna brännpunkter i företeelser som diplomati, kvinnors inflytande och tillskrivandet av betydelse hos förCan a silk glove be an expression of power? In this carefully curated volume, internation­ally renowned historians have come together to explore the interconnected perspectives of gender, materiality, and politics. As the authors elaborate on these topics, the volume offers contributions covering a period from the sixteenth century to the present day, investigating political culture and diplomacy,

Vegetation gross primary production (GPP) is the largest terrestrial carbon flux and plays an important role in regulating the carbon sink. Current terrestrial ecosystem models (TEMs) are indispensable tools for evaluating and predicting GPP. However, to which degree the TEMs can capture the interannual variability (IAV) of GPP remains unclear. With large data sets of remote sensing, in situ obser

Primary and secondary bile acids (BAs) influence metabolism and inflammation, and the gut microbiome modulates levels of BAs. We systematically explore the host genetic, gut microbial, and habitual dietary contribution to a panel of 19 serum and 15 stool BAs in two population-based cohorts (TwinsUK, n = 2,382; ZOE PREDICT-1, n = 327) and assess changes post-bariatric surgery and after nutritional

Machining-based deformation processing is used to produce metal foil and flat wire (strip) with suitable properties and quality for electrical power and renewable energy applications. In contrast to conventional multistage rolling, the strip is produced in a single-step and with much less process energy. Examples are presented from metal systems of varied workability, and strip product scale in te

Interfacial processes are involved in many areas of chemistry, physics and biochemistry, but following the structural changes of surfaces and thin films at relevant timescales remains challenging. Time-of flight neutron reflectometry can determine changes in surface composition and film thickness, but the speed of these measurements is typically limited by the neutron flux over the range of wavele

Human carbonic anhydrase II catalyzes the reversible reaction of carbon dioxide and water to form bicarbonate and a proton. His64-mediated proton shuttling between the active site and the bulk solvent is rate limiting. Here we investigate the protonation behavior of His64 as well as its structural and dynamic features in a pH dependent way. We derive two pK a values for His64, 6.25 and 7.60, that

We present an experimental study investigating the solvent-dependent dynamics of a 9,10-bis(phenylethynyl)anthracene monomer, dimer, and trimer. Using transient absorption spectroscopy, we have discovered that triplet excited state formation in the dimer and trimer molecules in polar solvents is a consequence of charge recombination subsequent to symmetry-breaking charge separation rather than sin

Kommunikatörsyrket inom offentlig sektor har på senare år varit på stark framväxt, men också i kraftig omvandling. Digitalisering, ökade förväntningar på organisationers kommunikation, en tilltagande medvetenhet i ledningen om kommunikationens strategiska betydelse, och alltmer komplexa verksamheter är några bakomliggande faktorer till den här utvecklingen. Det är också alltmer uppenbart att det s

The recent open letter from the Future of Life Institute (FLI) calling for a pause on the development of AI systems has generated a significant amount of discussion. We argue that more significant action to address the potential dangers of large, generative models, requires increased efforts on AI governance, and research funding structures to build a sustainable basis for transparent research on